Development and Validation of an Anion Exchange High-Performance Liquid Chromatography Method for Analysis of Empty Capsids and Capsids Encapsidating Genetic Material in a Purified Preparation of Recombinant Adeno-Associated Virus Serotype 5

The development of various manufacturing platforms and analytical technologies has substantially contributed to successfully translating the recombinant adeno-associated viral vector from the laboratory to the clinic. The active deployment of these analytical technologies for process and product cha...

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Veröffentlicht in:	Human gene therapy 2021-11, Vol.32 (21-22), p.1390-1402
Hauptverfasser:	Joshi, Pranav R H, Bernier, Alice, Chahal, Parminder S, Kamen, Amine
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino acids Anion exchange Anion exchanging Anions Capsid Capsids Chromatography Chromatography, High Pressure Liquid Correlation coefficient Correlation coefficients Dependovirus - genetics Fluorescence Genetic Vectors - genetics High performance liquid chromatography Liquid chromatography Mathematical analysis Methods Quality management Serogroup Ultracentrifugation Viruses
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