Prognostic value of P-wave morphology in general population
To evaluate the prognostic significance of novel P-wave morphology descriptors in general population. Novel P-wave morphology variables were analyzed from orthogonal X-, Y-, Z-leads of the digitized electrocardiogram using a custom-made software in 6906 middle-aged subjects of the Mini-Finland Healt...
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| Veröffentlicht in: | Europace (London, England) England), 2023-02, Vol.25 (1), p.164-174 |
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| creator | Laitinen, Idamaria Kenttä, Tuomas V Passi, Jussi Haukilahti, Mira Anette E Eranti, Antti Holkeri, Arttu Aro, Aapo L Kerola, Tuomas Noponen, Kai Seppänen, Tapio Rissanen, Harri Knekt, Paul Heliövaara, Markku Ukkola, Olavi H Junttila, M Juhani Huikuri, Heikki V Perkiömäki, Juha S |
| description | To evaluate the prognostic significance of novel P-wave morphology descriptors in general population.
Novel P-wave morphology variables were analyzed from orthogonal X-, Y-, Z-leads of the digitized electrocardiogram using a custom-made software in 6906 middle-aged subjects of the Mini-Finland Health Survey. A total of 3747 (54.3%) participants died during the follow-up period of 24.3 ± 10.4 years; 379 (5.5%) of the study population succumbed to sudden cardiac death (SCD), 928 (13.4%) to non-SCD (NSCD) and 2440 (35.3%) patients to non-cardiac death (NCD). In univariate comparisons, most of the studied P-wave morphology parameters had a significant association with all modes of death (P from |
| doi_str_mv | 10.1093/europace/euac121 |
| format | Article |
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Novel P-wave morphology variables were analyzed from orthogonal X-, Y-, Z-leads of the digitized electrocardiogram using a custom-made software in 6906 middle-aged subjects of the Mini-Finland Health Survey. A total of 3747 (54.3%) participants died during the follow-up period of 24.3 ± 10.4 years; 379 (5.5%) of the study population succumbed to sudden cardiac death (SCD), 928 (13.4%) to non-SCD (NSCD) and 2440 (35.3%) patients to non-cardiac death (NCD). In univariate comparisons, most of the studied P-wave morphology parameters had a significant association with all modes of death (P from <0.05 to <0.001). After relevant adjustments in the Cox multivariate hazards model, P-wave morphology dispersion (PMD) still tended to predict SCD [hazard ratio (HR): 1.006, 95% confidence interval (CI): 1.000-1.012, P = 0.05) but not NSCD (HR: 0.999, 95% CI: 0.995-1.003, P = 0.68) or NCD (HR: 0.999, 95% CI: 0.997-1.001, P = 0.44). The P-wave maximum amplitude in the lead Z (P-MaxAmp-Z) predicted SCD even after multivariate adjustments (HR: 1.010, 95% CI: 1.005-1.015, P = 0.0002) but also NSCD (HR: 1.005, 95% CI: 1.002-1.009, P = 0.0005) and NCD (HR: 1.002, 95% CI: 1.000-1.005, P = 0.03).
Abnormalities of P-wave morphology are associated with the risk of all modes of death in general population. After relevant adjustments, PMD was still closely associated with the risk of SCD but not with NSCD or NCD. P-MaxAmp-Z predicted SCD even after adjustments, however, it also retained its association with NSCD and NCD.</description><identifier>ISSN: 1099-5129</identifier><identifier>EISSN: 1532-2092</identifier><identifier>DOI: 10.1093/europace/euac121</identifier><identifier>PMID: 35852923</identifier><language>eng</language><publisher>England: Oxford University Press</publisher><subject>Clinical Research ; Death, Sudden, Cardiac - epidemiology ; Death, Sudden, Cardiac - etiology ; Death, Sudden, Cardiac - prevention & control ; Electrocardiography - methods ; Humans ; Middle Aged ; Noncommunicable Diseases ; Prognosis ; Risk Assessment ; Risk Factors</subject><ispartof>Europace (London, England), 2023-02, Vol.25 (1), p.164-174</ispartof><rights>The Author(s) 2022. Published by Oxford University Press on behalf of the European Society of Cardiology. All rights reserved. For permissions, please email: journals.permissions@oup.com.</rights><rights>The Author(s) 2022. Published by Oxford University Press on behalf of the European Society of Cardiology. All rights reserved. For permissions, please email: journals.permissions@oup.com. 2022</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c397t-772a7a3f8506ce4c2870f7cd92bdb79b5220c0bcb97872b67487ace519535023</citedby><cites>FETCH-LOGICAL-c397t-772a7a3f8506ce4c2870f7cd92bdb79b5220c0bcb97872b67487ace519535023</cites><orcidid>0000-0002-3963-0750 ; 0000-0002-2648-1338 ; 0000-0002-1157-3985 ; 0000-0002-9170-7727 ; 0000-0001-7030-6740 ; 0000-0001-7414-2608 ; 0000-0002-9844-3680 ; 0000-0002-8896-1281</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC10112844/pdf/$$EPDF$$P50$$Gpubmedcentral$$H</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC10112844/$$EHTML$$P50$$Gpubmedcentral$$H</linktohtml><link.rule.ids>230,314,723,776,780,881,27901,27902,53766,53768</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/35852923$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Laitinen, Idamaria</creatorcontrib><creatorcontrib>Kenttä, Tuomas V</creatorcontrib><creatorcontrib>Passi, Jussi</creatorcontrib><creatorcontrib>Haukilahti, Mira Anette E</creatorcontrib><creatorcontrib>Eranti, Antti</creatorcontrib><creatorcontrib>Holkeri, Arttu</creatorcontrib><creatorcontrib>Aro, Aapo L</creatorcontrib><creatorcontrib>Kerola, Tuomas</creatorcontrib><creatorcontrib>Noponen, Kai</creatorcontrib><creatorcontrib>Seppänen, Tapio</creatorcontrib><creatorcontrib>Rissanen, Harri</creatorcontrib><creatorcontrib>Knekt, Paul</creatorcontrib><creatorcontrib>Heliövaara, Markku</creatorcontrib><creatorcontrib>Ukkola, Olavi H</creatorcontrib><creatorcontrib>Junttila, M Juhani</creatorcontrib><creatorcontrib>Huikuri, Heikki V</creatorcontrib><creatorcontrib>Perkiömäki, Juha S</creatorcontrib><title>Prognostic value of P-wave morphology in general population</title><title>Europace (London, England)</title><addtitle>Europace</addtitle><description>To evaluate the prognostic significance of novel P-wave morphology descriptors in general population.
Novel P-wave morphology variables were analyzed from orthogonal X-, Y-, Z-leads of the digitized electrocardiogram using a custom-made software in 6906 middle-aged subjects of the Mini-Finland Health Survey. A total of 3747 (54.3%) participants died during the follow-up period of 24.3 ± 10.4 years; 379 (5.5%) of the study population succumbed to sudden cardiac death (SCD), 928 (13.4%) to non-SCD (NSCD) and 2440 (35.3%) patients to non-cardiac death (NCD). In univariate comparisons, most of the studied P-wave morphology parameters had a significant association with all modes of death (P from <0.05 to <0.001). After relevant adjustments in the Cox multivariate hazards model, P-wave morphology dispersion (PMD) still tended to predict SCD [hazard ratio (HR): 1.006, 95% confidence interval (CI): 1.000-1.012, P = 0.05) but not NSCD (HR: 0.999, 95% CI: 0.995-1.003, P = 0.68) or NCD (HR: 0.999, 95% CI: 0.997-1.001, P = 0.44). The P-wave maximum amplitude in the lead Z (P-MaxAmp-Z) predicted SCD even after multivariate adjustments (HR: 1.010, 95% CI: 1.005-1.015, P = 0.0002) but also NSCD (HR: 1.005, 95% CI: 1.002-1.009, P = 0.0005) and NCD (HR: 1.002, 95% CI: 1.000-1.005, P = 0.03).
Abnormalities of P-wave morphology are associated with the risk of all modes of death in general population. After relevant adjustments, PMD was still closely associated with the risk of SCD but not with NSCD or NCD. P-MaxAmp-Z predicted SCD even after adjustments, however, it also retained its association with NSCD and NCD.</description><subject>Clinical Research</subject><subject>Death, Sudden, Cardiac - epidemiology</subject><subject>Death, Sudden, Cardiac - etiology</subject><subject>Death, Sudden, Cardiac - prevention & control</subject><subject>Electrocardiography - methods</subject><subject>Humans</subject><subject>Middle Aged</subject><subject>Noncommunicable Diseases</subject><subject>Prognosis</subject><subject>Risk Assessment</subject><subject>Risk Factors</subject><issn>1099-5129</issn><issn>1532-2092</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2023</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpVUMtOwzAQtBCIQuHOCeXIJbBex3UsDghVvKRK9NC75bhOGpTEwU6K-vek6kNw2pF2ZnZ2CLmhcE9Bsgfbe9dqYwegDUV6Qi4oZxgjSDwdMEgZc4pyRC5D-AIAgZKfkxHjKUeJ7II8zr0rGhe60kRrXfU2cnk0j3_02ka18-3KVa7YRGUTFbaxXldR69q-0l3pmitylusq2Ov9HJPF68ti-h7PPt8-ps-z2DApulgI1EKzPOUwMTYxmArIhVlKzJaZkBlHBAOZyaRIBWYTkaRi-IlTyRkHZGPytLNt-6y2S2ObbsihWl_W2m-U06X6v2nKlSrcWlGgFNMkGRzu9g7effc2dKoug7FVpRvr-qBwIqlIZYJbKuyoxrsQvM2Pdyiobefq0Lnadz5Ibv_mOwoOJbNf4iWBUQ</recordid><startdate>20230208</startdate><enddate>20230208</enddate><creator>Laitinen, Idamaria</creator><creator>Kenttä, Tuomas V</creator><creator>Passi, Jussi</creator><creator>Haukilahti, Mira Anette E</creator><creator>Eranti, Antti</creator><creator>Holkeri, Arttu</creator><creator>Aro, Aapo L</creator><creator>Kerola, Tuomas</creator><creator>Noponen, Kai</creator><creator>Seppänen, Tapio</creator><creator>Rissanen, Harri</creator><creator>Knekt, Paul</creator><creator>Heliövaara, Markku</creator><creator>Ukkola, Olavi H</creator><creator>Junttila, M Juhani</creator><creator>Huikuri, Heikki V</creator><creator>Perkiömäki, Juha S</creator><general>Oxford University Press</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0002-3963-0750</orcidid><orcidid>https://orcid.org/0000-0002-2648-1338</orcidid><orcidid>https://orcid.org/0000-0002-1157-3985</orcidid><orcidid>https://orcid.org/0000-0002-9170-7727</orcidid><orcidid>https://orcid.org/0000-0001-7030-6740</orcidid><orcidid>https://orcid.org/0000-0001-7414-2608</orcidid><orcidid>https://orcid.org/0000-0002-9844-3680</orcidid><orcidid>https://orcid.org/0000-0002-8896-1281</orcidid></search><sort><creationdate>20230208</creationdate><title>Prognostic value of P-wave morphology in general population</title><author>Laitinen, Idamaria ; 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Novel P-wave morphology variables were analyzed from orthogonal X-, Y-, Z-leads of the digitized electrocardiogram using a custom-made software in 6906 middle-aged subjects of the Mini-Finland Health Survey. A total of 3747 (54.3%) participants died during the follow-up period of 24.3 ± 10.4 years; 379 (5.5%) of the study population succumbed to sudden cardiac death (SCD), 928 (13.4%) to non-SCD (NSCD) and 2440 (35.3%) patients to non-cardiac death (NCD). In univariate comparisons, most of the studied P-wave morphology parameters had a significant association with all modes of death (P from <0.05 to <0.001). After relevant adjustments in the Cox multivariate hazards model, P-wave morphology dispersion (PMD) still tended to predict SCD [hazard ratio (HR): 1.006, 95% confidence interval (CI): 1.000-1.012, P = 0.05) but not NSCD (HR: 0.999, 95% CI: 0.995-1.003, P = 0.68) or NCD (HR: 0.999, 95% CI: 0.997-1.001, P = 0.44). The P-wave maximum amplitude in the lead Z (P-MaxAmp-Z) predicted SCD even after multivariate adjustments (HR: 1.010, 95% CI: 1.005-1.015, P = 0.0002) but also NSCD (HR: 1.005, 95% CI: 1.002-1.009, P = 0.0005) and NCD (HR: 1.002, 95% CI: 1.000-1.005, P = 0.03).
Abnormalities of P-wave morphology are associated with the risk of all modes of death in general population. After relevant adjustments, PMD was still closely associated with the risk of SCD but not with NSCD or NCD. P-MaxAmp-Z predicted SCD even after adjustments, however, it also retained its association with NSCD and NCD.</abstract><cop>England</cop><pub>Oxford University Press</pub><pmid>35852923</pmid><doi>10.1093/europace/euac121</doi><tpages>11</tpages><orcidid>https://orcid.org/0000-0002-3963-0750</orcidid><orcidid>https://orcid.org/0000-0002-2648-1338</orcidid><orcidid>https://orcid.org/0000-0002-1157-3985</orcidid><orcidid>https://orcid.org/0000-0002-9170-7727</orcidid><orcidid>https://orcid.org/0000-0001-7030-6740</orcidid><orcidid>https://orcid.org/0000-0001-7414-2608</orcidid><orcidid>https://orcid.org/0000-0002-9844-3680</orcidid><orcidid>https://orcid.org/0000-0002-8896-1281</orcidid><oa>free_for_read</oa></addata></record> |
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| source | Oxford Journals Open Access Collection; MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; PubMed Central; Alma/SFX Local Collection |
| subjects | Clinical Research Death, Sudden, Cardiac - epidemiology Death, Sudden, Cardiac - etiology Death, Sudden, Cardiac - prevention & control Electrocardiography - methods Humans Middle Aged Noncommunicable Diseases Prognosis Risk Assessment Risk Factors |
| title | Prognostic value of P-wave morphology in general population |
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