Dissociative Transition State in Hepatitis Delta Virus Ribozyme Catalysis

Ribonucleases and small nucleolytic ribozymes are both able to catalyze RNA strand cleavage through 2′-O-transphosphorylation, provoking the question of whether protein and RNA enzymes facilitate mechanisms that pass through the same or distinct transition states. Here, we report the primary and sec...

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Veröffentlicht in:	Journal of the American Chemical Society 2023-02, Vol.145 (5), p.2830-2839
Hauptverfasser:	Weissman, Benjamin, Ekesan, Şölen, Lin, Hsuan-Chun, Gardezi, Shahbaz, Li, Nan-Sheng, Giese, Timothy J., McCarthy, Erika, Harris, Michael E., York, Darrin M., Piccirilli, Joseph A.
Format:	Artikel
Sprache:	eng
Schlagworte:	Catalysis Catalytic Domain Hepatitis Delta Virus - genetics Hepatitis Delta Virus - metabolism Kinetics Nucleic Acid Conformation RNA - chemistry RNA, Catalytic - chemistry
Online-Zugang:	Volltext
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