Ccn2a-FGFR1-SHH signaling is necessary for intervertebral disc homeostasis and regeneration in adult zebrafish

Intervertebral disc (IVD) degeneration is the primary cause of back pain in humans. However, the cellular and molecular pathogenesis of IVD degeneration is poorly understood. This study shows that zebrafish IVDs possess distinct and non-overlapping zones of cell proliferation and cell death. We find...

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Veröffentlicht in:	Development (Cambridge) 2023-01, Vol.150 (1)
Hauptverfasser:	Rayrikar, Amey Y, Wagh, Ganesh A, Santra, Manas K, Patra, Chinmoy
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Cell Communication Connective Tissue Growth Factor - genetics Connective Tissue Growth Factor - metabolism Hedgehog Proteins - metabolism Intervertebral Disc - metabolism Intervertebral Disc Degeneration - genetics Intervertebral Disc Degeneration - metabolism Intervertebral Disc Degeneration - pathology Nucleus Pulposus - metabolism Nucleus Pulposus - pathology Receptor, Fibroblast Growth Factor, Type 1 - genetics Receptor, Fibroblast Growth Factor, Type 1 - metabolism Signal Transduction - genetics Stem Cells and Regeneration Zebrafish Zebrafish Proteins - genetics Zebrafish Proteins - metabolism
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