Sounding the alarmins—The role of alarmin cytokines in asthma

The alarmin cytokines thymic stromal lymphopoietin (TSLP), interleukin (IL)‐33, and IL‐25 are epithelial cell‐derived mediators that contribute to the pathobiology and pathophysiology of asthma. Released from airway epithelial cells exposed to environmental triggers, the alarmins drive airway inflam...

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Veröffentlicht in:	Allergy (Copenhagen) 2023-02, Vol.78 (2), p.402-417
Hauptverfasser:	Gauvreau, Gail M., Bergeron, Celine, Boulet, Louis‐Philippe, Cockcroft, Donald W., Côté, Andréanne, Davis, Beth E., Leigh, Richard, Myers, Irvin, O'Byrne, Paul M., Sehmi, Roma
Format:	Artikel
Sprache:	eng
Schlagworte:	alarmin cytokines Alarmins - therapeutic use Allergens Asthma Blood diseases Bronchoconstriction Clinical trials Cytokines Cytokines - metabolism Effector cells eosinophilia Epithelial cells exacerbation Humans Inflammation Interleukin-1 Receptor-Like 1 Protein Interleukin-33 - metabolism Monoclonal antibodies Respiratory function Respiratory tract Respiratory tract diseases Review Thymic Stromal Lymphopoietin Thymus
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