A Dynamic Thermodynamic Resolution Strategy for the Stereocontrolled Synthesis of Streptonigrin

We report that axially chiral biaryl boronic esters can be generated with control of atroposelectivity by a Binol‐mediated dynamic thermodynamic resolution process. These intermediates can be progressed to enantioenriched products through stereoretentive functionalization of the carbon–boron bond. F...

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Veröffentlicht in:	Angewandte Chemie International Edition 2023-01, Vol.62 (5), p.e202213692-n/a
Hauptverfasser:	Valdez Pérez, Luis F., Bachollet, Sylvestre P. J. T., Orlov, Nikolai V., Kopf, Kenji P. M., Harrity, Joseph P. A.
Format:	Artikel
Sprache:	eng
Schlagworte:	Atropisomers Boron Boronic Esters Communication Communications Diastereoselectivity Dynamic Thermodynamic Resolution Esters Intermediates Stereoselectivity Streptonigrin Synthesis Thermodynamics Total Synthesis
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