The efficacy of GLP‐1RAs for the management of postprandial hypoglycemia following bariatric surgery: a systematic review
Objective Postprandial hyperinsulinemic hypoglycemia with neuroglycopenia is an increasingly recognized complication of Roux‐en‐Y gastric bypass and gastric sleeve surgery that may detrimentally affect patient quality of life. One likely causal factor is glucagon‐like peptide‐1 (GLP‐1), which has an...
Gespeichert in:
| Veröffentlicht in: | Obesity (Silver Spring, Md.) Md.), 2023-01, Vol.31 (1), p.20-30 |
|---|---|
| Hauptverfasser: | , , , , , , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 30 |
|---|---|
| container_issue | 1 |
| container_start_page | 20 |
| container_title | Obesity (Silver Spring, Md.) |
| container_volume | 31 |
| creator | Llewellyn, David C. Logan Ellis, Hugh Aylwin, Simon J. B. Oštarijaš, Eduard Green, Shauna Sheridan, William Chew, Nicholas W. S. Roux, Carel W. Miras, Alexander D. Patel, Ameet G. Vincent, Royce P. Dimitriadis, Georgios K. |
| description | Objective
Postprandial hyperinsulinemic hypoglycemia with neuroglycopenia is an increasingly recognized complication of Roux‐en‐Y gastric bypass and gastric sleeve surgery that may detrimentally affect patient quality of life. One likely causal factor is glucagon‐like peptide‐1 (GLP‐1), which has an exaggerated rise following ingestion of carbohydrates after bariatric surgery. This paper sought to assess the role of GLP‐1 receptor agonists (GLP‐1RAs) in managing postprandial hypoglycemia following bariatric surgery.
Methods
MEDLINE, Embase, Cochrane Central Register of Controlled Trials (CENTRAL), ClinicalTrials.gov, and Scopus were systematically and critically appraised for all peer‐reviewed publications that suitably fulfilled the inclusion criteria established a priori. This systematic review was developed according to the Preferred Reporting Items for Systematic Review and Meta‐Analyses Protocols (PRISMA‐P). It followed methods outlined in the Cochrane Handbook for Systematic Reviews of Interventions and is registered with PROSPERO (International Prospective Register of Systematic Reviews; identifier CRD420212716429).
Results and Conclusions
Postprandial hyperinsulinemic hypoglycemia remains a notoriously difficult to manage metabolic complication of bariatric surgery. This first, to the authors' knowledge, systematic review presents evidence suggesting that use of GLP‐1RAs does not lead to an increase of hypoglycemic episodes, and, although this approach may appear counterintuitive, the findings suggest that GLP‐1RAs could reduce the number of postprandial hypoglycemic episodes and improve glycemic variability. |
| doi_str_mv | 10.1002/oby.23600 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_10107620</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2759657978</sourcerecordid><originalsourceid>FETCH-LOGICAL-c4440-33ad8069ce942244defaf1c64da59d9d77005539197eb9cedfbb45000d3dff2a3</originalsourceid><addsrcrecordid>eNp10d1qFDEUB_BBFFurF76ABLzRi21PkvnYeCO1aCssVKSCXoUz-ZhNmZmMyUyXwRsfwWf0SZp166KCVwk5P_7k8M-ypxSOKQA78fV8zHgJcC87pILDouLi8_39fUkPskcxXgPkJRT0YXbAywIYWy4Ps29Xa0OMtU6hmom35Hz14ef3H_TjaSTWBzKmcYc9NqYz_bgFg4_jELDXDluyngfftLMyncPk29ZvXN-QGoPDMThF4hQaE-ZXBEmc42g6HNNrMDfObB5nDyy20Ty5O4-yT-_eXp1dLFaX5-_PTlcLlec5LDhHvYRSKCNyxvJcG4uWqjLXWAgtdFUBFAUXVFSmTkrbus4LANBcW8uQH2Wvd7nDVHdGq7RIwFYOwXUYZunRyb8nvVvLxt9IChSqkkFKeHGXEPzXycRRdi4q07bYGz9FyaqCM8FKuqXP_6HXfgp92m-rRFlUolom9XKnVPAxBmP3v6Egt53K1Kn81Wmyz_78_l7-LjGBkx3YuNbM_0-Sl2--7CJvATxErrw</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2759657978</pqid></control><display><type>article</type><title>The efficacy of GLP‐1RAs for the management of postprandial hypoglycemia following bariatric surgery: a systematic review</title><source>Wiley Free Content</source><source>MEDLINE</source><source>Wiley Online Library Journals Frontfile Complete</source><creator>Llewellyn, David C. ; Logan Ellis, Hugh ; Aylwin, Simon J. B. ; Oštarijaš, Eduard ; Green, Shauna ; Sheridan, William ; Chew, Nicholas W. S. ; Roux, Carel W. ; Miras, Alexander D. ; Patel, Ameet G. ; Vincent, Royce P. ; Dimitriadis, Georgios K.</creator><creatorcontrib>Llewellyn, David C. ; Logan Ellis, Hugh ; Aylwin, Simon J. B. ; Oštarijaš, Eduard ; Green, Shauna ; Sheridan, William ; Chew, Nicholas W. S. ; Roux, Carel W. ; Miras, Alexander D. ; Patel, Ameet G. ; Vincent, Royce P. ; Dimitriadis, Georgios K.</creatorcontrib><description>Objective
Postprandial hyperinsulinemic hypoglycemia with neuroglycopenia is an increasingly recognized complication of Roux‐en‐Y gastric bypass and gastric sleeve surgery that may detrimentally affect patient quality of life. One likely causal factor is glucagon‐like peptide‐1 (GLP‐1), which has an exaggerated rise following ingestion of carbohydrates after bariatric surgery. This paper sought to assess the role of GLP‐1 receptor agonists (GLP‐1RAs) in managing postprandial hypoglycemia following bariatric surgery.
Methods
MEDLINE, Embase, Cochrane Central Register of Controlled Trials (CENTRAL), ClinicalTrials.gov, and Scopus were systematically and critically appraised for all peer‐reviewed publications that suitably fulfilled the inclusion criteria established a priori. This systematic review was developed according to the Preferred Reporting Items for Systematic Review and Meta‐Analyses Protocols (PRISMA‐P). It followed methods outlined in the Cochrane Handbook for Systematic Reviews of Interventions and is registered with PROSPERO (International Prospective Register of Systematic Reviews; identifier CRD420212716429).
Results and Conclusions
Postprandial hyperinsulinemic hypoglycemia remains a notoriously difficult to manage metabolic complication of bariatric surgery. This first, to the authors' knowledge, systematic review presents evidence suggesting that use of GLP‐1RAs does not lead to an increase of hypoglycemic episodes, and, although this approach may appear counterintuitive, the findings suggest that GLP‐1RAs could reduce the number of postprandial hypoglycemic episodes and improve glycemic variability.</description><identifier>ISSN: 1930-7381</identifier><identifier>ISSN: 1930-739X</identifier><identifier>EISSN: 1930-739X</identifier><identifier>DOI: 10.1002/oby.23600</identifier><identifier>PMID: 36502288</identifier><language>eng</language><publisher>United States: Blackwell Publishing Ltd</publisher><subject>Bariatric Surgery - adverse effects ; Carbohydrates ; Dumping syndrome ; Food ; Gastrointestinal surgery ; GLP-1 receptor agonists ; Glucagon ; Glucagon-Like Peptide-1 Receptor - agonists ; Glucagon-Like Peptide-1 Receptor - therapeutic use ; Glucose ; Hormones ; Humans ; Hypoglycemia ; Hypoglycemia - etiology ; Hypoglycemia - prevention & control ; Insulin ; Meals ; Metabolism ; Nutrients ; Peptides ; Quality of Life ; Review ; REVIEWS ; Small intestine ; Systematic review ; Weight control</subject><ispartof>Obesity (Silver Spring, Md.), 2023-01, Vol.31 (1), p.20-30</ispartof><rights>2022 The Authors. published by Wiley Periodicals LLC on behalf of The Obesity Society.</rights><rights>2022 The Authors. Obesity published by Wiley Periodicals LLC on behalf of The Obesity Society.</rights><rights>Copyright Blackwell Publishing Ltd. Jan 2023</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4440-33ad8069ce942244defaf1c64da59d9d77005539197eb9cedfbb45000d3dff2a3</citedby><cites>FETCH-LOGICAL-c4440-33ad8069ce942244defaf1c64da59d9d77005539197eb9cedfbb45000d3dff2a3</cites><orcidid>0000-0002-0640-0430 ; 0000-0001-5521-5445 ; 0000-0003-3830-3173 ; 0000-0002-6662-804X</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Foby.23600$$EPDF$$P50$$Gwiley$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Foby.23600$$EHTML$$P50$$Gwiley$$Hfree_for_read</linktohtml><link.rule.ids>230,314,776,780,881,1411,1427,27903,27904,45553,45554,46387,46811</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/36502288$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Llewellyn, David C.</creatorcontrib><creatorcontrib>Logan Ellis, Hugh</creatorcontrib><creatorcontrib>Aylwin, Simon J. B.</creatorcontrib><creatorcontrib>Oštarijaš, Eduard</creatorcontrib><creatorcontrib>Green, Shauna</creatorcontrib><creatorcontrib>Sheridan, William</creatorcontrib><creatorcontrib>Chew, Nicholas W. S.</creatorcontrib><creatorcontrib>Roux, Carel W.</creatorcontrib><creatorcontrib>Miras, Alexander D.</creatorcontrib><creatorcontrib>Patel, Ameet G.</creatorcontrib><creatorcontrib>Vincent, Royce P.</creatorcontrib><creatorcontrib>Dimitriadis, Georgios K.</creatorcontrib><title>The efficacy of GLP‐1RAs for the management of postprandial hypoglycemia following bariatric surgery: a systematic review</title><title>Obesity (Silver Spring, Md.)</title><addtitle>Obesity (Silver Spring)</addtitle><description>Objective
Postprandial hyperinsulinemic hypoglycemia with neuroglycopenia is an increasingly recognized complication of Roux‐en‐Y gastric bypass and gastric sleeve surgery that may detrimentally affect patient quality of life. One likely causal factor is glucagon‐like peptide‐1 (GLP‐1), which has an exaggerated rise following ingestion of carbohydrates after bariatric surgery. This paper sought to assess the role of GLP‐1 receptor agonists (GLP‐1RAs) in managing postprandial hypoglycemia following bariatric surgery.
Methods
MEDLINE, Embase, Cochrane Central Register of Controlled Trials (CENTRAL), ClinicalTrials.gov, and Scopus were systematically and critically appraised for all peer‐reviewed publications that suitably fulfilled the inclusion criteria established a priori. This systematic review was developed according to the Preferred Reporting Items for Systematic Review and Meta‐Analyses Protocols (PRISMA‐P). It followed methods outlined in the Cochrane Handbook for Systematic Reviews of Interventions and is registered with PROSPERO (International Prospective Register of Systematic Reviews; identifier CRD420212716429).
Results and Conclusions
Postprandial hyperinsulinemic hypoglycemia remains a notoriously difficult to manage metabolic complication of bariatric surgery. This first, to the authors' knowledge, systematic review presents evidence suggesting that use of GLP‐1RAs does not lead to an increase of hypoglycemic episodes, and, although this approach may appear counterintuitive, the findings suggest that GLP‐1RAs could reduce the number of postprandial hypoglycemic episodes and improve glycemic variability.</description><subject>Bariatric Surgery - adverse effects</subject><subject>Carbohydrates</subject><subject>Dumping syndrome</subject><subject>Food</subject><subject>Gastrointestinal surgery</subject><subject>GLP-1 receptor agonists</subject><subject>Glucagon</subject><subject>Glucagon-Like Peptide-1 Receptor - agonists</subject><subject>Glucagon-Like Peptide-1 Receptor - therapeutic use</subject><subject>Glucose</subject><subject>Hormones</subject><subject>Humans</subject><subject>Hypoglycemia</subject><subject>Hypoglycemia - etiology</subject><subject>Hypoglycemia - prevention & control</subject><subject>Insulin</subject><subject>Meals</subject><subject>Metabolism</subject><subject>Nutrients</subject><subject>Peptides</subject><subject>Quality of Life</subject><subject>Review</subject><subject>REVIEWS</subject><subject>Small intestine</subject><subject>Systematic review</subject><subject>Weight control</subject><issn>1930-7381</issn><issn>1930-739X</issn><issn>1930-739X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2023</creationdate><recordtype>article</recordtype><sourceid>24P</sourceid><sourceid>EIF</sourceid><recordid>eNp10d1qFDEUB_BBFFurF76ABLzRi21PkvnYeCO1aCssVKSCXoUz-ZhNmZmMyUyXwRsfwWf0SZp166KCVwk5P_7k8M-ypxSOKQA78fV8zHgJcC87pILDouLi8_39fUkPskcxXgPkJRT0YXbAywIYWy4Ps29Xa0OMtU6hmom35Hz14ef3H_TjaSTWBzKmcYc9NqYz_bgFg4_jELDXDluyngfftLMyncPk29ZvXN-QGoPDMThF4hQaE-ZXBEmc42g6HNNrMDfObB5nDyy20Ty5O4-yT-_eXp1dLFaX5-_PTlcLlec5LDhHvYRSKCNyxvJcG4uWqjLXWAgtdFUBFAUXVFSmTkrbus4LANBcW8uQH2Wvd7nDVHdGq7RIwFYOwXUYZunRyb8nvVvLxt9IChSqkkFKeHGXEPzXycRRdi4q07bYGz9FyaqCM8FKuqXP_6HXfgp92m-rRFlUolom9XKnVPAxBmP3v6Egt53K1Kn81Wmyz_78_l7-LjGBkx3YuNbM_0-Sl2--7CJvATxErrw</recordid><startdate>202301</startdate><enddate>202301</enddate><creator>Llewellyn, David C.</creator><creator>Logan Ellis, Hugh</creator><creator>Aylwin, Simon J. B.</creator><creator>Oštarijaš, Eduard</creator><creator>Green, Shauna</creator><creator>Sheridan, William</creator><creator>Chew, Nicholas W. S.</creator><creator>Roux, Carel W.</creator><creator>Miras, Alexander D.</creator><creator>Patel, Ameet G.</creator><creator>Vincent, Royce P.</creator><creator>Dimitriadis, Georgios K.</creator><general>Blackwell Publishing Ltd</general><general>John Wiley and Sons Inc</general><scope>24P</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>K9.</scope><scope>7X8</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0002-0640-0430</orcidid><orcidid>https://orcid.org/0000-0001-5521-5445</orcidid><orcidid>https://orcid.org/0000-0003-3830-3173</orcidid><orcidid>https://orcid.org/0000-0002-6662-804X</orcidid></search><sort><creationdate>202301</creationdate><title>The efficacy of GLP‐1RAs for the management of postprandial hypoglycemia following bariatric surgery: a systematic review</title><author>Llewellyn, David C. ; Logan Ellis, Hugh ; Aylwin, Simon J. B. ; Oštarijaš, Eduard ; Green, Shauna ; Sheridan, William ; Chew, Nicholas W. S. ; Roux, Carel W. ; Miras, Alexander D. ; Patel, Ameet G. ; Vincent, Royce P. ; Dimitriadis, Georgios K.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4440-33ad8069ce942244defaf1c64da59d9d77005539197eb9cedfbb45000d3dff2a3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2023</creationdate><topic>Bariatric Surgery - adverse effects</topic><topic>Carbohydrates</topic><topic>Dumping syndrome</topic><topic>Food</topic><topic>Gastrointestinal surgery</topic><topic>GLP-1 receptor agonists</topic><topic>Glucagon</topic><topic>Glucagon-Like Peptide-1 Receptor - agonists</topic><topic>Glucagon-Like Peptide-1 Receptor - therapeutic use</topic><topic>Glucose</topic><topic>Hormones</topic><topic>Humans</topic><topic>Hypoglycemia</topic><topic>Hypoglycemia - etiology</topic><topic>Hypoglycemia - prevention & control</topic><topic>Insulin</topic><topic>Meals</topic><topic>Metabolism</topic><topic>Nutrients</topic><topic>Peptides</topic><topic>Quality of Life</topic><topic>Review</topic><topic>REVIEWS</topic><topic>Small intestine</topic><topic>Systematic review</topic><topic>Weight control</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Llewellyn, David C.</creatorcontrib><creatorcontrib>Logan Ellis, Hugh</creatorcontrib><creatorcontrib>Aylwin, Simon J. B.</creatorcontrib><creatorcontrib>Oštarijaš, Eduard</creatorcontrib><creatorcontrib>Green, Shauna</creatorcontrib><creatorcontrib>Sheridan, William</creatorcontrib><creatorcontrib>Chew, Nicholas W. S.</creatorcontrib><creatorcontrib>Roux, Carel W.</creatorcontrib><creatorcontrib>Miras, Alexander D.</creatorcontrib><creatorcontrib>Patel, Ameet G.</creatorcontrib><creatorcontrib>Vincent, Royce P.</creatorcontrib><creatorcontrib>Dimitriadis, Georgios K.</creatorcontrib><collection>Wiley Online Library Open Access</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Obesity (Silver Spring, Md.)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Llewellyn, David C.</au><au>Logan Ellis, Hugh</au><au>Aylwin, Simon J. B.</au><au>Oštarijaš, Eduard</au><au>Green, Shauna</au><au>Sheridan, William</au><au>Chew, Nicholas W. S.</au><au>Roux, Carel W.</au><au>Miras, Alexander D.</au><au>Patel, Ameet G.</au><au>Vincent, Royce P.</au><au>Dimitriadis, Georgios K.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The efficacy of GLP‐1RAs for the management of postprandial hypoglycemia following bariatric surgery: a systematic review</atitle><jtitle>Obesity (Silver Spring, Md.)</jtitle><addtitle>Obesity (Silver Spring)</addtitle><date>2023-01</date><risdate>2023</risdate><volume>31</volume><issue>1</issue><spage>20</spage><epage>30</epage><pages>20-30</pages><issn>1930-7381</issn><issn>1930-739X</issn><eissn>1930-739X</eissn><abstract>Objective
Postprandial hyperinsulinemic hypoglycemia with neuroglycopenia is an increasingly recognized complication of Roux‐en‐Y gastric bypass and gastric sleeve surgery that may detrimentally affect patient quality of life. One likely causal factor is glucagon‐like peptide‐1 (GLP‐1), which has an exaggerated rise following ingestion of carbohydrates after bariatric surgery. This paper sought to assess the role of GLP‐1 receptor agonists (GLP‐1RAs) in managing postprandial hypoglycemia following bariatric surgery.
Methods
MEDLINE, Embase, Cochrane Central Register of Controlled Trials (CENTRAL), ClinicalTrials.gov, and Scopus were systematically and critically appraised for all peer‐reviewed publications that suitably fulfilled the inclusion criteria established a priori. This systematic review was developed according to the Preferred Reporting Items for Systematic Review and Meta‐Analyses Protocols (PRISMA‐P). It followed methods outlined in the Cochrane Handbook for Systematic Reviews of Interventions and is registered with PROSPERO (International Prospective Register of Systematic Reviews; identifier CRD420212716429).
Results and Conclusions
Postprandial hyperinsulinemic hypoglycemia remains a notoriously difficult to manage metabolic complication of bariatric surgery. This first, to the authors' knowledge, systematic review presents evidence suggesting that use of GLP‐1RAs does not lead to an increase of hypoglycemic episodes, and, although this approach may appear counterintuitive, the findings suggest that GLP‐1RAs could reduce the number of postprandial hypoglycemic episodes and improve glycemic variability.</abstract><cop>United States</cop><pub>Blackwell Publishing Ltd</pub><pmid>36502288</pmid><doi>10.1002/oby.23600</doi><tpages>11</tpages><orcidid>https://orcid.org/0000-0002-0640-0430</orcidid><orcidid>https://orcid.org/0000-0001-5521-5445</orcidid><orcidid>https://orcid.org/0000-0003-3830-3173</orcidid><orcidid>https://orcid.org/0000-0002-6662-804X</orcidid><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1930-7381 |
| ispartof | Obesity (Silver Spring, Md.), 2023-01, Vol.31 (1), p.20-30 |
| issn | 1930-7381 1930-739X 1930-739X |
| language | eng |
| recordid | cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_10107620 |
| source | Wiley Free Content; MEDLINE; Wiley Online Library Journals Frontfile Complete |
| subjects | Bariatric Surgery - adverse effects Carbohydrates Dumping syndrome Food Gastrointestinal surgery GLP-1 receptor agonists Glucagon Glucagon-Like Peptide-1 Receptor - agonists Glucagon-Like Peptide-1 Receptor - therapeutic use Glucose Hormones Humans Hypoglycemia Hypoglycemia - etiology Hypoglycemia - prevention & control Insulin Meals Metabolism Nutrients Peptides Quality of Life Review REVIEWS Small intestine Systematic review Weight control |
| title | The efficacy of GLP‐1RAs for the management of postprandial hypoglycemia following bariatric surgery: a systematic review |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-27T17%3A03%3A57IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_pubme&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=The%20efficacy%20of%20GLP%E2%80%901RAs%20for%20the%20management%20of%20postprandial%20hypoglycemia%20following%20bariatric%20surgery:%20a%20systematic%20review&rft.jtitle=Obesity%20(Silver%20Spring,%20Md.)&rft.au=Llewellyn,%20David%20C.&rft.date=2023-01&rft.volume=31&rft.issue=1&rft.spage=20&rft.epage=30&rft.pages=20-30&rft.issn=1930-7381&rft.eissn=1930-739X&rft_id=info:doi/10.1002/oby.23600&rft_dat=%3Cproquest_pubme%3E2759657978%3C/proquest_pubme%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2759657978&rft_id=info:pmid/36502288&rfr_iscdi=true |