A Systematic Review of the Usage of Rotigotine During Early and Advanced Stage Parkinson's
Parkinson's disease (PD) is a prevalent neurodegenerative disorder that occurs in old age due to a decrease in dopamine, which causes nerve cell destruction. This disease is difficult to diagnose since its symptoms are similar to those of the aging process. Those with PD have impaired motor con...
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| Veröffentlicht in: | Curēus (Palo Alto, CA) CA), 2023-03, Vol.15 (3), p.e36211-e36211 |
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| creator | Rajendran, Avanthika Reddy, Akshay J Bisaga, Karol Sommer, Dillon A Prakash, Neha Pokala, Vivek T Yu, Zeyu Bachir, Mark Nawathey, Neel Brahmbhatt, Telak Patel, Rakesh |
| description | Parkinson's disease (PD) is a prevalent neurodegenerative disorder that occurs in old age due to a decrease in dopamine, which causes nerve cell destruction. This disease is difficult to diagnose since its symptoms are similar to those of the aging process. Those with PD have impaired motor control and function, dyskinesia, and tremors. To treat PD, drugs that enhance the amount of dopamine given to the brain are administered to alleviate symptoms. This inquiry examines the prescription of rotigotine to achieve this objective. The primary objective of this review is to examine the usage of rotigotine in both the late and early stages of PD. The statistical model utilized in the review found that there was not a significant difference in the dosage of rotigotine prescribed to late and early-stage PD patients, however, there were some confounding variables that may have skewed this result; therefore, further research is necessary to validate or nullify this hypothesis. |
| doi_str_mv | 10.7759/cureus.36211 |
| format | Article |
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This disease is difficult to diagnose since its symptoms are similar to those of the aging process. Those with PD have impaired motor control and function, dyskinesia, and tremors. To treat PD, drugs that enhance the amount of dopamine given to the brain are administered to alleviate symptoms. This inquiry examines the prescription of rotigotine to achieve this objective. The primary objective of this review is to examine the usage of rotigotine in both the late and early stages of PD. The statistical model utilized in the review found that there was not a significant difference in the dosage of rotigotine prescribed to late and early-stage PD patients, however, there were some confounding variables that may have skewed this result; therefore, further research is necessary to validate or nullify this hypothesis.</description><identifier>ISSN: 2168-8184</identifier><identifier>EISSN: 2168-8184</identifier><identifier>DOI: 10.7759/cureus.36211</identifier><identifier>PMID: 37069881</identifier><language>eng</language><publisher>United States: Cureus Inc</publisher><subject>Blood-brain barrier ; Dopamine ; Fecal incontinence ; Parkinson's disease ; Patients ; Public Health ; Statistical analysis</subject><ispartof>Curēus (Palo Alto, CA), 2023-03, Vol.15 (3), p.e36211-e36211</ispartof><rights>Copyright © 2023, Rajendran et al.</rights><rights>Copyright © 2023, Rajendran et al. This work is published under https://creativecommons.org/licenses/by/3.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>Copyright © 2023, Rajendran et al. 2023 Rajendran et al.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c300t-8b1a3cefbedb9942f5cbca8a1f03c482d7f1c8a6c04de603eebe520c52a210b73</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC10105263/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC10105263/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,315,728,781,785,886,27929,27930,53796,53798</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/37069881$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Rajendran, Avanthika</creatorcontrib><creatorcontrib>Reddy, Akshay J</creatorcontrib><creatorcontrib>Bisaga, Karol</creatorcontrib><creatorcontrib>Sommer, Dillon A</creatorcontrib><creatorcontrib>Prakash, Neha</creatorcontrib><creatorcontrib>Pokala, Vivek T</creatorcontrib><creatorcontrib>Yu, Zeyu</creatorcontrib><creatorcontrib>Bachir, Mark</creatorcontrib><creatorcontrib>Nawathey, Neel</creatorcontrib><creatorcontrib>Brahmbhatt, Telak</creatorcontrib><creatorcontrib>Patel, Rakesh</creatorcontrib><title>A Systematic Review of the Usage of Rotigotine During Early and Advanced Stage Parkinson's</title><title>Curēus (Palo Alto, CA)</title><addtitle>Cureus</addtitle><description>Parkinson's disease (PD) is a prevalent neurodegenerative disorder that occurs in old age due to a decrease in dopamine, which causes nerve cell destruction. 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The statistical model utilized in the review found that there was not a significant difference in the dosage of rotigotine prescribed to late and early-stage PD patients, however, there were some confounding variables that may have skewed this result; therefore, further research is necessary to validate or nullify this hypothesis.</description><subject>Blood-brain barrier</subject><subject>Dopamine</subject><subject>Fecal incontinence</subject><subject>Parkinson's disease</subject><subject>Patients</subject><subject>Public Health</subject><subject>Statistical analysis</subject><issn>2168-8184</issn><issn>2168-8184</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2023</creationdate><recordtype>article</recordtype><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><recordid>eNpdkU1PGzEQhq2qqCCaG2dkqYf2QNKxvbv2nqqIz0pIIEIuXCyvdzYYNja1d4Py79k0gGgPo5nRPHo1My8hBwwmUublT9tH7NNEFJyxT2SPs0KNFVPZ5w_1Lhml9AAADCQHCV_IrpBQlEqxPXI3pbN16nBpOmfpDa4cPtPQ0O4e6TyZBW6am9C5xRAe6UkfnV_QUxPbNTW-ptN6ZbzFms66DX1t4qPzKfjv6SvZaUybcPSa98n87PT2-GJ8eXX--3h6ObYCoBurihlhsamwrsoy401uK2uUYQ0Imyley4ZZZQoLWY0FCMQKcw4254YzqKTYJ7-2uk99tcTaou-iafVTdEsT1zoYp_-deHevF2Gl2fCRnBdiUPjxqhDDnx5Tp5cuWWxb4zH0SXMFXKmcyWxAv_2HPoQ--uG-DSUVL3lZDtTRlrIxpBSxed-Ggd4Yp7fG6b_GDfjhxwve4TebxAthZ5XO</recordid><startdate>20230315</startdate><enddate>20230315</enddate><creator>Rajendran, Avanthika</creator><creator>Reddy, Akshay J</creator><creator>Bisaga, Karol</creator><creator>Sommer, Dillon A</creator><creator>Prakash, Neha</creator><creator>Pokala, Vivek T</creator><creator>Yu, Zeyu</creator><creator>Bachir, Mark</creator><creator>Nawathey, Neel</creator><creator>Brahmbhatt, Telak</creator><creator>Patel, Rakesh</creator><general>Cureus Inc</general><general>Cureus</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>M0S</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20230315</creationdate><title>A Systematic Review of the Usage of Rotigotine During Early and Advanced Stage Parkinson's</title><author>Rajendran, Avanthika ; 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| source | PubMed Central Open Access; PubMed Central |
| subjects | Blood-brain barrier Dopamine Fecal incontinence Parkinson's disease Patients Public Health Statistical analysis |
| title | A Systematic Review of the Usage of Rotigotine During Early and Advanced Stage Parkinson's |
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