GDF11 promotes wound healing in diabetic mice via stimulating HIF-1ɑ-VEGF/SDF-1ɑ-mediated endothelial progenitor cell mobilization and neovascularization

Non-healing diabetic wounds (DW) are a serious clinical problem that remained poorly understood. We recently found that topical application of growth differentiation factor 11 (GDF11) accelerated skin wound healing in both Type 1 DM (T1DM) and genetically engineered Type 2 diabetic db/db (T2DM) mice...

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Veröffentlicht in:	Acta pharmacologica Sinica 2023-05, Vol.44 (5), p.999-1013
Hauptverfasser:	Zhang, Ying, Zhang, Yi-yuan, Pan, Zhen-wei, Li, Qing-qi, Sun, Li-hua, Li, Xin, Gong, Man-yu, Yang, Xue-wen, Wang, Yan-ying, Li, Hao-dong, Xuan, Li-na, Shao, Ying-chun, Li, Meng-meng, Zhang, Ming-yu, Yu, Qi, Li, Zhange, Zhang, Xiao-fang, Liu, Dong-hua, Zhu, Yan-meng, Tan, Zhong-yue, Zhang, Yuan-yuan, Liu, Yun-qi, Zhang, Yong, Jiao, Lei, Yang, Bao-feng
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biomedical and Life Sciences Biomedicine Biopsy Bone Morphogenetic Proteins - metabolism Chemokine CXCL12 - drug effects Chemokine CXCL12 - metabolism Diabetes Diabetes mellitus Diabetes Mellitus, Experimental - complications Diabetes Mellitus, Experimental - drug therapy Diabetes Mellitus, Experimental - metabolism Diabetes Mellitus, Type 2 - drug therapy Diabetes Mellitus, Type 2 - metabolism Endothelial Progenitor Cells - metabolism Endothelial Progenitor Cells - pathology Genetic engineering Growth differentiation factor 11 Growth Differentiation Factors - metabolism Growth Differentiation Factors - therapeutic use Homing behavior Humans Hypoxia-Inducible Factor 1, alpha Subunit - drug effects Hypoxia-Inducible Factor 1, alpha Subunit - metabolism Immunology Internal Medicine Medical Microbiology Mice Molecular modelling Neovascularization, Physiologic Pharmacology/Toxicology Progenitor cells Recombinant Proteins - metabolism Recombinant Proteins - therapeutic use Regeneration siRNA Skin Topical application Vaccine Vascular endothelial growth factor Vascular Endothelial Growth Factor A - drug effects Vascular Endothelial Growth Factor A - metabolism Vascularization Wound healing Wound Healing - drug effects
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