Antioxidant Mechanisms Underlying the Gastroprotective Effect of Menthofuran on Experimentally Induced Gastric Lesions in Rodents
Menthofuran is a monoterpene present in various essential oils derived from species from Mentha genus, and in Brazil, those species are widely used in treating gastrointestinal and respiratory disorders. Considering the wide pharmacological potential of monoterpenes, including their antioxidant acti...
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| Veröffentlicht in: | Evidence-based complementary and alternative medicine 2023, Vol.2023 (1), p.9192494-9192494 |
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| creator | Alves, Naira Moura Nunes, Paulo Humberto Moreira Mendes Garcez, Anderson Lima de Freitas, Manoela Carine Oliveira, Irisdalva Sousa Silva, Francilene Vieira da Fernandes, Hélio de Barros Sousa, Damião Pergentino de Oliveira, Rita de Cássia Meneses Arcanjo, Daniel Dias Rufino Martins, Maria do Carmo de Carvalho e |
| description | Menthofuran is a monoterpene present in various essential oils derived from species from Mentha genus, and in Brazil, those species are widely used in treating gastrointestinal and respiratory disorders. Considering the wide pharmacological potential of monoterpenes, including their antioxidant activity, this study aimed to evaluate menthofuran-gastroprotective activity, as well as the involvement of antioxidant mechanisms in this effect. The acute toxicity was evaluated according to the fixed dose method. The antiulcerogenic activity was investigated by using experimental models of gastric ulcers induced by ethanol, indomethacin, and ischemia/reperfusion in rats. The antisecretory gastric activity, the catalase activity, and the gastric wall mucus were determined in pylorus ligated rats. Gastric wall nonprotein sulfhydryl (NPSH) group content, myeloperoxidase (MPO) activity, and malondialdehyde (MDA) content were evaluated in ethanol-induced the gastric ulcer model. Menthofuran (2 g/kg) presented low acute toxicity and showed gastroprotective activity against ethanol-, indomethacin-, and ischemia/reperfusion-induced ulcers. Moreover, menthofuran presented antisecretory activity, reduced the total acidity, and increased pH of gastric secretion. On the other hand, a decrease in mucus content of gastric wall without alteration of gastric juice volume and catalase activity was observed. Interestingly, menthofuran increased NPSH levels and reduced MDA levels and MPO activity. Gastroprotective effects of menthofuran appear to be mediated, at least in part, by the NOS pathway, endogenous prostaglandins, reduced gastric juice acidity, increased concentration of the NPSH groups, and reduced lipidic peroxidation. These findings support the menthofuran as an effective gastroprotective agent, as well as the marked participation of antioxidant mechanisms in this response. |
| doi_str_mv | 10.1155/2023/9192494 |
| format | Article |
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Considering the wide pharmacological potential of monoterpenes, including their antioxidant activity, this study aimed to evaluate menthofuran-gastroprotective activity, as well as the involvement of antioxidant mechanisms in this effect. The acute toxicity was evaluated according to the fixed dose method. The antiulcerogenic activity was investigated by using experimental models of gastric ulcers induced by ethanol, indomethacin, and ischemia/reperfusion in rats. The antisecretory gastric activity, the catalase activity, and the gastric wall mucus were determined in pylorus ligated rats. Gastric wall nonprotein sulfhydryl (NPSH) group content, myeloperoxidase (MPO) activity, and malondialdehyde (MDA) content were evaluated in ethanol-induced the gastric ulcer model. Menthofuran (2 g/kg) presented low acute toxicity and showed gastroprotective activity against ethanol-, indomethacin-, and ischemia/reperfusion-induced ulcers. Moreover, menthofuran presented antisecretory activity, reduced the total acidity, and increased pH of gastric secretion. On the other hand, a decrease in mucus content of gastric wall without alteration of gastric juice volume and catalase activity was observed. Interestingly, menthofuran increased NPSH levels and reduced MDA levels and MPO activity. Gastroprotective effects of menthofuran appear to be mediated, at least in part, by the NOS pathway, endogenous prostaglandins, reduced gastric juice acidity, increased concentration of the NPSH groups, and reduced lipidic peroxidation. These findings support the menthofuran as an effective gastroprotective agent, as well as the marked participation of antioxidant mechanisms in this response.</description><identifier>ISSN: 1741-427X</identifier><identifier>EISSN: 1741-4288</identifier><identifier>DOI: 10.1155/2023/9192494</identifier><identifier>PMID: 37064952</identifier><language>eng</language><publisher>United States: Hindawi</publisher><subject>Abdomen ; Acidity ; Acute toxicity ; Animals ; Antioxidants ; Catalase ; Computers ; Drug dosages ; Essential oils ; Ethanol ; Gastric juice ; Herbal medicine ; Indomethacin ; Ischemia ; Lipid peroxidation ; Monoterpenes ; Mucus ; Natural products ; Nonsteroidal anti-inflammatory drugs ; Oils & fats ; Peroxidase ; Peroxidation ; Prostaglandins ; Reperfusion ; Sodium ; Stomach ; Ulcers</subject><ispartof>Evidence-based complementary and alternative medicine, 2023, Vol.2023 (1), p.9192494-9192494</ispartof><rights>Copyright © 2023 Naira Moura Alves et al.</rights><rights>Copyright © 2023 Naira Moura Alves et al. This is an open access article distributed under the Creative Commons Attribution License (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License. https://creativecommons.org/licenses/by/4.0</rights><rights>Copyright © 2023 Naira Moura Alves et al. 2023</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3644-df2aac336534bd2e9f754bbb529f0ee71e4304c8d986a0d1ffc5e42789c47f313</citedby><cites>FETCH-LOGICAL-c3644-df2aac336534bd2e9f754bbb529f0ee71e4304c8d986a0d1ffc5e42789c47f313</cites><orcidid>0000-0002-9107-2485 ; 0000-0001-7021-2744 ; 0000-0001-9745-9763 ; 0000-0002-9245-4303 ; 0000-0002-1954-8573 ; 0000-0002-7180-4896 ; 0000-0003-3647-1587</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC10104745/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC10104745/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,315,728,781,785,886,4025,27928,27929,27930,53796,53798</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/37064952$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><contributor>Kabra, Atul</contributor><contributor>Atul Kabra</contributor><creatorcontrib>Alves, Naira Moura</creatorcontrib><creatorcontrib>Nunes, Paulo Humberto Moreira</creatorcontrib><creatorcontrib>Mendes Garcez, Anderson</creatorcontrib><creatorcontrib>Lima de Freitas, Manoela Carine</creatorcontrib><creatorcontrib>Oliveira, Irisdalva Sousa</creatorcontrib><creatorcontrib>Silva, Francilene Vieira da</creatorcontrib><creatorcontrib>Fernandes, Hélio de Barros</creatorcontrib><creatorcontrib>Sousa, Damião Pergentino de</creatorcontrib><creatorcontrib>Oliveira, Rita de Cássia Meneses</creatorcontrib><creatorcontrib>Arcanjo, Daniel Dias Rufino</creatorcontrib><creatorcontrib>Martins, Maria do Carmo de Carvalho e</creatorcontrib><title>Antioxidant Mechanisms Underlying the Gastroprotective Effect of Menthofuran on Experimentally Induced Gastric Lesions in Rodents</title><title>Evidence-based complementary and alternative medicine</title><addtitle>Evid Based Complement Alternat Med</addtitle><description>Menthofuran is a monoterpene present in various essential oils derived from species from Mentha genus, and in Brazil, those species are widely used in treating gastrointestinal and respiratory disorders. Considering the wide pharmacological potential of monoterpenes, including their antioxidant activity, this study aimed to evaluate menthofuran-gastroprotective activity, as well as the involvement of antioxidant mechanisms in this effect. The acute toxicity was evaluated according to the fixed dose method. The antiulcerogenic activity was investigated by using experimental models of gastric ulcers induced by ethanol, indomethacin, and ischemia/reperfusion in rats. The antisecretory gastric activity, the catalase activity, and the gastric wall mucus were determined in pylorus ligated rats. Gastric wall nonprotein sulfhydryl (NPSH) group content, myeloperoxidase (MPO) activity, and malondialdehyde (MDA) content were evaluated in ethanol-induced the gastric ulcer model. Menthofuran (2 g/kg) presented low acute toxicity and showed gastroprotective activity against ethanol-, indomethacin-, and ischemia/reperfusion-induced ulcers. Moreover, menthofuran presented antisecretory activity, reduced the total acidity, and increased pH of gastric secretion. On the other hand, a decrease in mucus content of gastric wall without alteration of gastric juice volume and catalase activity was observed. Interestingly, menthofuran increased NPSH levels and reduced MDA levels and MPO activity. Gastroprotective effects of menthofuran appear to be mediated, at least in part, by the NOS pathway, endogenous prostaglandins, reduced gastric juice acidity, increased concentration of the NPSH groups, and reduced lipidic peroxidation. These findings support the menthofuran as an effective gastroprotective agent, as well as the marked participation of antioxidant mechanisms in this response.</description><subject>Abdomen</subject><subject>Acidity</subject><subject>Acute toxicity</subject><subject>Animals</subject><subject>Antioxidants</subject><subject>Catalase</subject><subject>Computers</subject><subject>Drug dosages</subject><subject>Essential oils</subject><subject>Ethanol</subject><subject>Gastric juice</subject><subject>Herbal medicine</subject><subject>Indomethacin</subject><subject>Ischemia</subject><subject>Lipid peroxidation</subject><subject>Monoterpenes</subject><subject>Mucus</subject><subject>Natural products</subject><subject>Nonsteroidal anti-inflammatory drugs</subject><subject>Oils & 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Anderson</au><au>Lima de Freitas, Manoela Carine</au><au>Oliveira, Irisdalva Sousa</au><au>Silva, Francilene Vieira da</au><au>Fernandes, Hélio de Barros</au><au>Sousa, Damião Pergentino de</au><au>Oliveira, Rita de Cássia Meneses</au><au>Arcanjo, Daniel Dias Rufino</au><au>Martins, Maria do Carmo de Carvalho e</au><au>Kabra, Atul</au><au>Atul Kabra</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Antioxidant Mechanisms Underlying the Gastroprotective Effect of Menthofuran on Experimentally Induced Gastric Lesions in Rodents</atitle><jtitle>Evidence-based complementary and alternative medicine</jtitle><addtitle>Evid Based Complement Alternat Med</addtitle><date>2023</date><risdate>2023</risdate><volume>2023</volume><issue>1</issue><spage>9192494</spage><epage>9192494</epage><pages>9192494-9192494</pages><issn>1741-427X</issn><eissn>1741-4288</eissn><abstract>Menthofuran is a monoterpene present in various essential oils derived from species from Mentha genus, and in Brazil, those species are widely used in treating gastrointestinal and respiratory disorders. Considering the wide pharmacological potential of monoterpenes, including their antioxidant activity, this study aimed to evaluate menthofuran-gastroprotective activity, as well as the involvement of antioxidant mechanisms in this effect. The acute toxicity was evaluated according to the fixed dose method. The antiulcerogenic activity was investigated by using experimental models of gastric ulcers induced by ethanol, indomethacin, and ischemia/reperfusion in rats. The antisecretory gastric activity, the catalase activity, and the gastric wall mucus were determined in pylorus ligated rats. Gastric wall nonprotein sulfhydryl (NPSH) group content, myeloperoxidase (MPO) activity, and malondialdehyde (MDA) content were evaluated in ethanol-induced the gastric ulcer model. Menthofuran (2 g/kg) presented low acute toxicity and showed gastroprotective activity against ethanol-, indomethacin-, and ischemia/reperfusion-induced ulcers. Moreover, menthofuran presented antisecretory activity, reduced the total acidity, and increased pH of gastric secretion. On the other hand, a decrease in mucus content of gastric wall without alteration of gastric juice volume and catalase activity was observed. Interestingly, menthofuran increased NPSH levels and reduced MDA levels and MPO activity. Gastroprotective effects of menthofuran appear to be mediated, at least in part, by the NOS pathway, endogenous prostaglandins, reduced gastric juice acidity, increased concentration of the NPSH groups, and reduced lipidic peroxidation. These findings support the menthofuran as an effective gastroprotective agent, as well as the marked participation of antioxidant mechanisms in this response.</abstract><cop>United States</cop><pub>Hindawi</pub><pmid>37064952</pmid><doi>10.1155/2023/9192494</doi><tpages>1</tpages><orcidid>https://orcid.org/0000-0002-9107-2485</orcidid><orcidid>https://orcid.org/0000-0001-7021-2744</orcidid><orcidid>https://orcid.org/0000-0001-9745-9763</orcidid><orcidid>https://orcid.org/0000-0002-9245-4303</orcidid><orcidid>https://orcid.org/0000-0002-1954-8573</orcidid><orcidid>https://orcid.org/0000-0002-7180-4896</orcidid><orcidid>https://orcid.org/0000-0003-3647-1587</orcidid><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1741-427X |
| ispartof | Evidence-based complementary and alternative medicine, 2023, Vol.2023 (1), p.9192494-9192494 |
| issn | 1741-427X 1741-4288 |
| language | eng |
| recordid | cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_10104745 |
| source | Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; PubMed Central Open Access; Wiley-Blackwell Open Access Titles; PubMed Central; Alma/SFX Local Collection |
| subjects | Abdomen Acidity Acute toxicity Animals Antioxidants Catalase Computers Drug dosages Essential oils Ethanol Gastric juice Herbal medicine Indomethacin Ischemia Lipid peroxidation Monoterpenes Mucus Natural products Nonsteroidal anti-inflammatory drugs Oils & fats Peroxidase Peroxidation Prostaglandins Reperfusion Sodium Stomach Ulcers |
| title | Antioxidant Mechanisms Underlying the Gastroprotective Effect of Menthofuran on Experimentally Induced Gastric Lesions in Rodents |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-15T17%3A32%3A11IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_pubme&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Antioxidant%20Mechanisms%20Underlying%20the%20Gastroprotective%20Effect%20of%20Menthofuran%20on%20Experimentally%20Induced%20Gastric%20Lesions%20in%20Rodents&rft.jtitle=Evidence-based%20complementary%20and%20alternative%20medicine&rft.au=Alves,%20Naira%20Moura&rft.date=2023&rft.volume=2023&rft.issue=1&rft.spage=9192494&rft.epage=9192494&rft.pages=9192494-9192494&rft.issn=1741-427X&rft.eissn=1741-4288&rft_id=info:doi/10.1155/2023/9192494&rft_dat=%3Cproquest_pubme%3E2801794963%3C/proquest_pubme%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2801794963&rft_id=info:pmid/37064952&rfr_iscdi=true |