Whole-genome sequences from wild-type and laboratory-evolved strains define the alleleome and establish its hallmarks

The genomic diversity across strains of a species forms the genetic basis for differences in their behavior. A large-scale assessment of sequence variation has been made possible by the growing availability of strain-specific whole-genome sequences (WGS) and with the advent of large-scale databases...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 2023-04, Vol.120 (15), p.e2218835120-e2218835120
Hauptverfasser:	Catoiu, Edward Alexander, Phaneuf, Patrick, Monk, Jonathan, Palsson, Bernhard O
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Sequence Amino acids Biological evolution Biological Sciences E coli Escherichia coli - genetics Gene sequencing Genetic diversity Genetic Variation Genome, Bacterial - genetics Mutation Natural selection Nucleotide sequence Open reading frames Strains (organisms)
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