IOA-244 is a Non-ATP-competitive, Highly Selective, Tolerable PI3K Delta Inhibitor That Targets Solid Tumors and Breaks Immune Tolerance

PI3K delta (PI3Kδ) inhibitors are used to treat lymphomas but safety concerns and limited target selectivity curbed their clinical usefulness. PI3Kδ inhibition in solid tumors has recently emerged as a potential novel anticancer therapy through the modulation of T-cell responses and direct antitumor...

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Veröffentlicht in:	Cancer research communications 2023-04, Vol.3 (4), p.576-591
Hauptverfasser:	Johnson, Zoë, Tarantelli, Chiara, Civanelli, Elisa, Cascione, Luciano, Spriano, Filippo, Fraser, Amy, Shah, Pritom, Nomanbhoy, Tyzoon, Napoli, Sara, Rinaldi, Andrea, Niewola-Staszkowska, Karolina, Lahn, Michael, Perrin, Dominique, Wenes, Mathias, Migliorini, Denis, Bertoni, Francesco, van der Veen, Lars, Di Conza, Giusy
Format:	Artikel
Sprache:	eng
Schlagworte:	Drug Mechanisms Immunology Preclinical Models Small Molecule Agents Translational Research Tumor Microenvironment
Online-Zugang:	Volltext
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