Identification of the NA+/K+-ATPase α-Isoforms in Six Species of Poison Dart Frogs and their Sensitivity to Cardiotonic Steroids

Cardiotonic steroids (CTS) are a group of compounds known to be toxic due to their ability to inhibit the Na + /K + -ATPase (NKA), which is essential to maintain the balance of ions in animal cells. An evolutionary strategy of molecular adaptation to avoid self-intoxication acquired by CTS defended...

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Veröffentlicht in:	Journal of chemical ecology 2023-04, Vol.49 (3-4), p.116-132
Hauptverfasser:	Medina-Ortiz, Katherine, Navia, Felipe, Mosquera-Gil, Claudia, Sánchez, Adalberto, Sterling, Gonzalo, Fierro, Leonardo, Castaño, Santiago
Format:	Artikel
Sprache:	eng
Schlagworte:	Acid resistance Affinity Agriculture amino acid sequences Amino acid substitution Amino acids Amphibians Andinobates Animals arthropods Biochemistry Biological Microscopy Biomedical and Life Sciences Cardiac Glycosides Colombia diet dietary exposure Ecological effects Ecology Entomology Enzyme inhibitors Epipedobates Frogs Gene expression Intoxication Ions - metabolism Isoenzymes - genetics Isoenzymes - metabolism Isoforms Life Sciences Lipophilic lipophilicity Na+/K+-exchanging ATPase Oophaga Phenotypes Phyllobates Phyllobates aurotaenia Physiological effects Poisons Predators Reptiles & amphibians Skeletal muscle Sodium - metabolism sodium-potassium-exchanging ATPase Sodium-Potassium-Exchanging ATPase - genetics Sodium-Potassium-Exchanging ATPase - metabolism Steroid hormones Steroids toxicity Toxins transcriptome Transcriptomes
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