Curcumin protects against doxorubicin induced oxidative stress by regulating the Keap1-Nrf2-ARE and autophagy signaling pathways

Background Doxorubicin (DOX)-induced neurotoxicity is widely reported in previous studies. Oxidative stress has been validated as a critical event involved in DOX-induced neurotoxicity. As a selective autophagy adaptor protein, p62 is reported to regulate Keap1-Nrf2-ARE antioxidant pathway in respon...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Psychopharmacology 2023-05, Vol.240 (5), p.1179-1190
Hauptverfasser:	Liao, Dehua, Shangguan, Danggang, Wu, Yi, Chen, Yun, Liu, Ni, Tang, Jingyi, Yao, Dunwu, Shi, Yingrui
Format:	Artikel
Sprache:	eng
Schlagworte:	Adaptor proteins Analysis Animals Antimitotic agents Antineoplastic agents Autophagy Autophagy (Cytology) Behavior Biochemical analysis Biomedical and Life Sciences Biomedicine Complications and side effects Curcumin Curcumin - pharmacology Dosage and administration Doxorubicin Doxorubicin - toxicity Endoplasmic reticulum Health aspects Kelch-Like ECH-Associated Protein 1 - metabolism Neurosciences Neurotoxicity NF-E2-Related Factor 2 - metabolism Original Investigation Oxidative Stress Pharmacology/Toxicology Psychiatry Rats Signal Transduction Sucrose Turmeric
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!