Role of microRNAs in programmed cell death in renal diseases: A review
MicroRNAs (miRNAs) regulate gene expression involving kidney morphogenesis and cell proliferation, apoptosis, differentiation, migration, invasion, immune evasion, and extracellular matrix remodeling. Programmed cell death (PCD) is mediated and regulated by specific genes and a wealth of miRNAs, whi...
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| Veröffentlicht in: | Medicine (Baltimore) 2023-04, Vol.102 (15), p.e33453-e33453 |
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| container_title | Medicine (Baltimore) |
| container_volume | 102 |
| creator | Zhang, Yan Lv, Xinghua Chen, Feng Fan, Qian Liu, Yongqiang Wan, Zhanhai Nibaruta, Janvier Lv, Jipeng Han, Xuena Wu, Lin Wang, Hao Leng, Yufang |
| description | MicroRNAs (miRNAs) regulate gene expression involving kidney morphogenesis and cell proliferation, apoptosis, differentiation, migration, invasion, immune evasion, and extracellular matrix remodeling. Programmed cell death (PCD) is mediated and regulated by specific genes and a wealth of miRNAs, which participate in various pathological processes. Dysregulation of miRNAs can disrupt renal development and induce the onset and progression of various renal diseases. An in-depth understanding of how miRNAs regulate renal development and diseases is indispensable to comprehending how they can be used in new diagnostic and therapeutic approaches. However, the mechanisms are still insufficiently investigated. Hence, we review the current roles of miRNA-related signaling pathways and recent advances in PCD research and aim to display the potential crosstalk between miRNAs and PCD. The prospects of miRNAs as novel biomarkers and therapeutic targets are also described, which might provide some novel ideas for further studies. |
| doi_str_mv | 10.1097/MD.0000000000033453 |
| format | Article |
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Programmed cell death (PCD) is mediated and regulated by specific genes and a wealth of miRNAs, which participate in various pathological processes. Dysregulation of miRNAs can disrupt renal development and induce the onset and progression of various renal diseases. An in-depth understanding of how miRNAs regulate renal development and diseases is indispensable to comprehending how they can be used in new diagnostic and therapeutic approaches. However, the mechanisms are still insufficiently investigated. Hence, we review the current roles of miRNA-related signaling pathways and recent advances in PCD research and aim to display the potential crosstalk between miRNAs and PCD. The prospects of miRNAs as novel biomarkers and therapeutic targets are also described, which might provide some novel ideas for further studies.</description><identifier>ISSN: 0025-7974</identifier><identifier>EISSN: 1536-5964</identifier><identifier>DOI: 10.1097/MD.0000000000033453</identifier><identifier>PMID: 37058073</identifier><language>eng</language><publisher>United States: Lippincott Williams & Wilkins</publisher><subject>Apoptosis - genetics ; Biomarkers ; Cell Differentiation ; Humans ; MicroRNAs - genetics ; MicroRNAs - metabolism ; Narrative Review</subject><ispartof>Medicine (Baltimore), 2023-04, Vol.102 (15), p.e33453-e33453</ispartof><rights>Lippincott Williams & Wilkins</rights><rights>Copyright © 2023 the Author(s). Published by Wolters Kluwer Health, Inc.</rights><rights>Copyright © 2023 the Author(s). Published by Wolters Kluwer Health, Inc. 2023</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c4013-ca4a4b97ec6bb661e6367e97101d1a5568aeefbaba51cfd76a9f35be9b36638c3</cites><orcidid>0000-0002-7617-9962</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC10101263/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC10101263/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,315,728,781,785,865,886,27929,27930,53796,53798</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/37058073$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Zhang, Yan</creatorcontrib><creatorcontrib>Lv, Xinghua</creatorcontrib><creatorcontrib>Chen, Feng</creatorcontrib><creatorcontrib>Fan, Qian</creatorcontrib><creatorcontrib>Liu, Yongqiang</creatorcontrib><creatorcontrib>Wan, Zhanhai</creatorcontrib><creatorcontrib>Nibaruta, Janvier</creatorcontrib><creatorcontrib>Lv, Jipeng</creatorcontrib><creatorcontrib>Han, Xuena</creatorcontrib><creatorcontrib>Wu, Lin</creatorcontrib><creatorcontrib>Wang, Hao</creatorcontrib><creatorcontrib>Leng, Yufang</creatorcontrib><title>Role of microRNAs in programmed cell death in renal diseases: A review</title><title>Medicine (Baltimore)</title><addtitle>Medicine (Baltimore)</addtitle><description>MicroRNAs (miRNAs) regulate gene expression involving kidney morphogenesis and cell proliferation, apoptosis, differentiation, migration, invasion, immune evasion, and extracellular matrix remodeling. Programmed cell death (PCD) is mediated and regulated by specific genes and a wealth of miRNAs, which participate in various pathological processes. Dysregulation of miRNAs can disrupt renal development and induce the onset and progression of various renal diseases. An in-depth understanding of how miRNAs regulate renal development and diseases is indispensable to comprehending how they can be used in new diagnostic and therapeutic approaches. However, the mechanisms are still insufficiently investigated. Hence, we review the current roles of miRNA-related signaling pathways and recent advances in PCD research and aim to display the potential crosstalk between miRNAs and PCD. The prospects of miRNAs as novel biomarkers and therapeutic targets are also described, which might provide some novel ideas for further studies.</description><subject>Apoptosis - genetics</subject><subject>Biomarkers</subject><subject>Cell Differentiation</subject><subject>Humans</subject><subject>MicroRNAs - genetics</subject><subject>MicroRNAs - metabolism</subject><subject>Narrative Review</subject><issn>0025-7974</issn><issn>1536-5964</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2023</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpdUclOwzAQtRAIyvIFSChHLgE73mIuqCqrxCIhOFuTdEIDSVzslIq_x6Xsvow88-a9NzOE7DJ6wKjRh9cnB_TncS4kXyEDJrlKpVFilQwozWSqjRYbZDOEJ0oZ15lYJxtcU5lTzQfk7M41mLgqaevSu7ubYUjqLpl69-ihbXGclNg0yRihnywKHjuI3zogBAxHyTBmXmucb5O1CpqAO59xizycnd6PLtKr2_PL0fAqLUUUT0sQIAqjsVRFoRRDxZVGoxllYwZSqhwQqwIKkKysxlqBqbgs0BRcKZ6XfIscL3mnsyK6K7HrPTR26usW_Jt1UNu_la6e2Ef3aqMCZZnikWH_k8G7lxmG3rZ1WAwJHbpZsFlOmdGa5VmE8iU0biYEj9W3DqN2cQJ7fWL_nyB27f22-N3ztfMIEEvA3DU9-vDczObo7QSh6ScffFKbLM1oxqlggqYxE42_A6vIkTU</recordid><startdate>20230414</startdate><enddate>20230414</enddate><creator>Zhang, Yan</creator><creator>Lv, Xinghua</creator><creator>Chen, Feng</creator><creator>Fan, Qian</creator><creator>Liu, Yongqiang</creator><creator>Wan, Zhanhai</creator><creator>Nibaruta, Janvier</creator><creator>Lv, Jipeng</creator><creator>Han, Xuena</creator><creator>Wu, Lin</creator><creator>Wang, Hao</creator><creator>Leng, Yufang</creator><general>Lippincott Williams & Wilkins</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0002-7617-9962</orcidid></search><sort><creationdate>20230414</creationdate><title>Role of microRNAs in programmed cell death in renal diseases: A review</title><author>Zhang, Yan ; Lv, Xinghua ; Chen, Feng ; Fan, Qian ; Liu, Yongqiang ; Wan, Zhanhai ; Nibaruta, Janvier ; Lv, Jipeng ; Han, Xuena ; Wu, Lin ; Wang, Hao ; Leng, Yufang</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4013-ca4a4b97ec6bb661e6367e97101d1a5568aeefbaba51cfd76a9f35be9b36638c3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2023</creationdate><topic>Apoptosis - genetics</topic><topic>Biomarkers</topic><topic>Cell Differentiation</topic><topic>Humans</topic><topic>MicroRNAs - genetics</topic><topic>MicroRNAs - metabolism</topic><topic>Narrative Review</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Zhang, Yan</creatorcontrib><creatorcontrib>Lv, Xinghua</creatorcontrib><creatorcontrib>Chen, Feng</creatorcontrib><creatorcontrib>Fan, Qian</creatorcontrib><creatorcontrib>Liu, Yongqiang</creatorcontrib><creatorcontrib>Wan, Zhanhai</creatorcontrib><creatorcontrib>Nibaruta, Janvier</creatorcontrib><creatorcontrib>Lv, Jipeng</creatorcontrib><creatorcontrib>Han, Xuena</creatorcontrib><creatorcontrib>Wu, Lin</creatorcontrib><creatorcontrib>Wang, Hao</creatorcontrib><creatorcontrib>Leng, Yufang</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Medicine (Baltimore)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Zhang, Yan</au><au>Lv, Xinghua</au><au>Chen, Feng</au><au>Fan, Qian</au><au>Liu, Yongqiang</au><au>Wan, Zhanhai</au><au>Nibaruta, Janvier</au><au>Lv, Jipeng</au><au>Han, Xuena</au><au>Wu, Lin</au><au>Wang, Hao</au><au>Leng, Yufang</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Role of microRNAs in programmed cell death in renal diseases: A review</atitle><jtitle>Medicine (Baltimore)</jtitle><addtitle>Medicine (Baltimore)</addtitle><date>2023-04-14</date><risdate>2023</risdate><volume>102</volume><issue>15</issue><spage>e33453</spage><epage>e33453</epage><pages>e33453-e33453</pages><issn>0025-7974</issn><eissn>1536-5964</eissn><abstract>MicroRNAs (miRNAs) regulate gene expression involving kidney morphogenesis and cell proliferation, apoptosis, differentiation, migration, invasion, immune evasion, and extracellular matrix remodeling. Programmed cell death (PCD) is mediated and regulated by specific genes and a wealth of miRNAs, which participate in various pathological processes. Dysregulation of miRNAs can disrupt renal development and induce the onset and progression of various renal diseases. An in-depth understanding of how miRNAs regulate renal development and diseases is indispensable to comprehending how they can be used in new diagnostic and therapeutic approaches. However, the mechanisms are still insufficiently investigated. Hence, we review the current roles of miRNA-related signaling pathways and recent advances in PCD research and aim to display the potential crosstalk between miRNAs and PCD. 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| source | MEDLINE; DOAJ Directory of Open Access Journals; Wolters Kluwer Open Health; IngentaConnect Free/Open Access Journals; EZB-FREE-00999 freely available EZB journals; PubMed Central; Alma/SFX Local Collection |
| subjects | Apoptosis - genetics Biomarkers Cell Differentiation Humans MicroRNAs - genetics MicroRNAs - metabolism Narrative Review |
| title | Role of microRNAs in programmed cell death in renal diseases: A review |
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