Hyperaccurate Ribosomes for Improved Genetic Code Reprogramming

The reprogramming of the genetic code through the introduction of noncanonical amino acids (ncAAs) has enabled exciting advances in synthetic biology and peptide drug discovery. Ribosomes that function with high efficiency and fidelity are necessary for all of these efforts, but for challenging ncAA...

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Veröffentlicht in:	ACS synthetic biology 2022-06, Vol.11 (6), p.2193-2201
Hauptverfasser:	Shakya, Bipasana, Joyner, Olivia G., Hartman, Matthew C. T.
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acids - metabolism Anticodon Codon - genetics Codon - metabolism Genetic Code - genetics Peptides - metabolism Protein Biosynthesis - genetics Ribosomes - metabolism RNA, Transfer - genetics RNA, Transfer - metabolism
Online-Zugang:	Volltext
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