Regulation of caries‐induced pulp inflammation by NLRP3 inflammasome: A laboratory‐based investigation

Aim To evaluate the expression and function of the nod‐like receptor pyrin domain containing 3 (NLRP3) inflammasome in caries induced pulpitis. Methodology NLRP3 expression was determined with immunohistochemistry in the dental pulp and qPCR in dental pulp cells (DPCs). THP‐1 macrophages expressing...

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Veröffentlicht in:	International endodontic journal 2023-02, Vol.56 (2), p.193-202
Hauptverfasser:	Al Natour, Banan, Lundy, Fionnuala T., About, Imad, Jeanneau, Charlotte, Dombrowski, Yvonne, El Karim, Ikhlas A.
Format:	Artikel
Sprache:	eng
Schlagworte:	Apoptosis Biological Research caries bacteria Caspase Caspases Cell activation Cell death Cytokines Cytokines - metabolism Dental caries Dental Caries Susceptibility Dental pulp Enzyme-linked immunosorbent assay Fusion protein Green fluorescent protein Humans Immunohistochemistry Inflammasomes Inflammasomes - metabolism Inflammation Inflammation - metabolism Interleukin 6 Interleukin-1beta - metabolism Life Sciences Lipopolysaccharides Lipopolysaccharides - pharmacology Lipoteichoic acid Macrophages Matrix metalloproteinase Metalloproteinase NLR Family, Pyrin Domain-Containing 3 Protein - metabolism NLRP3 inflammasome Original Proteins pulp death Pulpitis Pyrin protein Sulfonamides vital pulp treatment
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