HU308 Mitigates Osteoarthritis by Stimulating Sox9‐Related Networks of Carbohydrate Metabolism

ABSTRACT Osteoarthritis (OA) is characterized by progressive, irreversible erosion of articular cartilage accompanied by severe pain and immobility. This study aimed to assess the effect and mechanism of action of HU308, a selective cannabinoid receptor type 2 (CB2) agonist, in preventing OA‐related...

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Veröffentlicht in:	Journal of bone and mineral research 2023-01, Vol.38 (1), p.154-170
Hauptverfasser:	Carmon, Idan, Zecharyahu, Lital, Elayyan, Jinan, Meka, Sai R. K., Reich, Eli, Kandel, Leonid, Bilkei‐Gorzo, Andras, Zimmer, Andreas, Mechoulam, Raphael, Kravchenko‐Balasha, Nataly, Dvir‐Ginzberg, Mona
Format:	Artikel
Sprache:	eng
Schlagworte:	Aged Aging Animals Arthritis Cannabinoid CB2 receptors Cannabinoids - pharmacology Carbohydrate Metabolism Carbohydrates Cartilage Cartilage (articular) Cartilage diseases Cartilage, Articular - metabolism Chondrocytes Chondrocytes - metabolism Chromatin HU308 Humans Immunoblotting Immunoprecipitation Metabolism Mice Mice, Knockout Osteoarthritis Osteoarthritis - drug therapy Osteoarthritis - genetics Osteoarthritis - metabolism Pain Pain - metabolism Sox9 protein SOX9 Transcription Factor - genetics SOX9 Transcription Factor - metabolism SOX9 Transcription Factor - pharmacology Subpopulations Synovitis Transcriptomics Trauma
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