DNA virus oncoprotein HPV18 E7 selectively antagonizes cGAS‐STING‐triggered innate immune activation

Cellular infections by DNA viruses trigger innate immune responses mediated by DNA sensors. The cyclic GMP–AMP synthase (cGAS)‐stimulator of interferon gene (STING) signaling pathway has been identified as a DNA‐sensing pathway that activates interferons in response to viral infection and, thus, med...

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Veröffentlicht in:	Journal of medical virology 2023-01, Vol.95 (1), p.e28310-n/a
Hauptverfasser:	Lou, Meng, Huang, Dingbo, Zhou, Zhenbang, Shi, Xinyu, Wu, Miaowei, Rui, Yajuan, Su, Jiaming, Zheng, Wenwen, Yu, Xiao‐Fang
Format:	Artikel
Sprache:	eng
Schlagworte:	Cell activation cGAS‐STING pathway convergent evolution Coronaviruses COVID-19 Deoxyribonucleic acid DNA DNA tumor virus DNA tumor viruses DNA viruses DNA Viruses - genetics DNA Viruses - metabolism HIV HPV18 E7 Human immunodeficiency virus Human papillomavirus Human papillomavirus 18 - genetics Humans Immunity, Innate Infections Innate immunity Interferon Interferon regulatory factor Interferon regulatory factor 1 Interferon regulatory factor 3 Interferon-beta - genetics Kaposi's sarcoma Lymphocytes B NF-kappa B - metabolism Nucleotidyltransferases - genetics Nucleotidyltransferases - metabolism Oncogene Proteins Oncoproteins Pathogenicity Pathogens Protein X Proteins Sarcoma Severe acute respiratory syndrome Short Communication Short Communications Signal transduction Stimulators Tumors Viral diseases Viral infections Virology Viruses
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