Vitamin D in Depression: A Potential Bioactive Agent to Reduce Suicide and Suicide Attempt Risk
Suicide is one of the leading causes of death worldwide. According to the World Health Organization (WHO), every year, more than 700 thousand people die from this cause. Therefore, suicide is a public health issue. The complex interaction between different factors causes suicide; however, depression...
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| Veröffentlicht in: | Nutrients 2023-04, Vol.15 (7), p.1765 |
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| creator | Somoza-Moncada, María Montserrat Turrubiates-Hernández, Francisco Javier Muñoz-Valle, José Francisco Gutiérrez-Brito, Jesús Alberto Díaz-Pérez, Saúl Alberto Aguayo-Arelis, Adriana Hernández-Bello, Jorge |
| description | Suicide is one of the leading causes of death worldwide. According to the World Health Organization (WHO), every year, more than 700 thousand people die from this cause. Therefore, suicide is a public health issue. The complex interaction between different factors causes suicide; however, depression is one of the most frequent factors in people who have attempted suicide. Several studies have reported that vitamin D deficiency may be a relevant risk factor for depression, and vitamin D supplementation has shown promising effects in the adjunctive treatment of this mood disorder. Among the beneficial mechanisms of vitamin D, it has been proposed that it may enhance serotonin synthesis and modulate proinflammatory cytokines since low serotonin levels and systemic inflammation have been associated with depression and suicide. The present narrative review shows the potential pathogenic role of vitamin D deficiency in depression and suicide and the potential benefits of vitamin D supplementation to reduce their risk. |
| doi_str_mv | 10.3390/nu15071765 |
| format | Article |
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According to the World Health Organization (WHO), every year, more than 700 thousand people die from this cause. Therefore, suicide is a public health issue. The complex interaction between different factors causes suicide; however, depression is one of the most frequent factors in people who have attempted suicide. Several studies have reported that vitamin D deficiency may be a relevant risk factor for depression, and vitamin D supplementation has shown promising effects in the adjunctive treatment of this mood disorder. Among the beneficial mechanisms of vitamin D, it has been proposed that it may enhance serotonin synthesis and modulate proinflammatory cytokines since low serotonin levels and systemic inflammation have been associated with depression and suicide. The present narrative review shows the potential pathogenic role of vitamin D deficiency in depression and suicide and the potential benefits of vitamin D supplementation to reduce their risk.</description><identifier>ISSN: 2072-6643</identifier><identifier>EISSN: 2072-6643</identifier><identifier>DOI: 10.3390/nu15071765</identifier><identifier>PMID: 37049606</identifier><language>eng</language><publisher>Switzerland: MDPI AG</publisher><subject>Alfacalcidol ; Biomarkers ; Brain ; Calcifediol ; Calciferol ; Complications and side effects ; Depression - drug therapy ; Diet therapy ; Dietary supplements ; Health aspects ; Humans ; Inflammation ; Major depressive disorder ; Mental depression ; Mental disorders ; Mental health ; Metabolism ; Metabolites ; Prevention ; Public health ; Review ; Risk factors ; Self destructive behavior ; Serotonin ; Suicidal behavior ; Suicidal Ideation ; Suicide ; Suicide, Attempted ; Suicides & suicide attempts ; Transcription factors ; Vitamin D ; Vitamin D - therapeutic use ; Vitamin D deficiency ; Vitamin D Deficiency - complications ; Vitamin D Deficiency - drug therapy ; Vitamin deficiency ; Vitamins - therapeutic use</subject><ispartof>Nutrients, 2023-04, Vol.15 (7), p.1765</ispartof><rights>COPYRIGHT 2023 MDPI AG</rights><rights>2023 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>2023 by the authors. 2023</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c474t-6cb46c4e15c14bf338c99472790acf1ced6bd799cc7026ef681640bd0ea016c93</citedby><cites>FETCH-LOGICAL-c474t-6cb46c4e15c14bf338c99472790acf1ced6bd799cc7026ef681640bd0ea016c93</cites><orcidid>0000-0003-3225-5174 ; 0000-0001-9637-168X ; 0009-0002-4065-0414 ; 0000-0002-2272-9260 ; 0000-0001-8004-1811</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC10097210/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC10097210/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,724,777,781,882,27905,27906,53772,53774</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/37049606$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Somoza-Moncada, María Montserrat</creatorcontrib><creatorcontrib>Turrubiates-Hernández, Francisco Javier</creatorcontrib><creatorcontrib>Muñoz-Valle, José Francisco</creatorcontrib><creatorcontrib>Gutiérrez-Brito, Jesús Alberto</creatorcontrib><creatorcontrib>Díaz-Pérez, Saúl Alberto</creatorcontrib><creatorcontrib>Aguayo-Arelis, Adriana</creatorcontrib><creatorcontrib>Hernández-Bello, Jorge</creatorcontrib><title>Vitamin D in Depression: A Potential Bioactive Agent to Reduce Suicide and Suicide Attempt Risk</title><title>Nutrients</title><addtitle>Nutrients</addtitle><description>Suicide is one of the leading causes of death worldwide. According to the World Health Organization (WHO), every year, more than 700 thousand people die from this cause. Therefore, suicide is a public health issue. The complex interaction between different factors causes suicide; however, depression is one of the most frequent factors in people who have attempted suicide. Several studies have reported that vitamin D deficiency may be a relevant risk factor for depression, and vitamin D supplementation has shown promising effects in the adjunctive treatment of this mood disorder. Among the beneficial mechanisms of vitamin D, it has been proposed that it may enhance serotonin synthesis and modulate proinflammatory cytokines since low serotonin levels and systemic inflammation have been associated with depression and suicide. The present narrative review shows the potential pathogenic role of vitamin D deficiency in depression and suicide and the potential benefits of vitamin D supplementation to reduce their risk.</description><subject>Alfacalcidol</subject><subject>Biomarkers</subject><subject>Brain</subject><subject>Calcifediol</subject><subject>Calciferol</subject><subject>Complications and side effects</subject><subject>Depression - drug therapy</subject><subject>Diet therapy</subject><subject>Dietary supplements</subject><subject>Health aspects</subject><subject>Humans</subject><subject>Inflammation</subject><subject>Major depressive disorder</subject><subject>Mental depression</subject><subject>Mental disorders</subject><subject>Mental health</subject><subject>Metabolism</subject><subject>Metabolites</subject><subject>Prevention</subject><subject>Public health</subject><subject>Review</subject><subject>Risk factors</subject><subject>Self destructive behavior</subject><subject>Serotonin</subject><subject>Suicidal behavior</subject><subject>Suicidal Ideation</subject><subject>Suicide</subject><subject>Suicide, Attempted</subject><subject>Suicides & suicide attempts</subject><subject>Transcription factors</subject><subject>Vitamin D</subject><subject>Vitamin D - therapeutic use</subject><subject>Vitamin D deficiency</subject><subject>Vitamin D Deficiency - complications</subject><subject>Vitamin D Deficiency - drug therapy</subject><subject>Vitamin deficiency</subject><subject>Vitamins - therapeutic use</subject><issn>2072-6643</issn><issn>2072-6643</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2023</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><recordid>eNptUl1rFDEUDaLYsvbFHyABX0TY9maSTSa-yFhtKxSU-vEaMpk7a-pMsk4yBf-9WVq3HzSB5HJz7sk9l0PISwaHnGs4CjNbgWJKrp6Q_QpUtZRS8Kd34j1ykNIlbJcCJflzsscVCC1B7hPz02c7-kA_0u2BmwlT8jG8ow39GjOG7O1AP_hoXfZXSJt1SdEc6QV2s0P6bfbOd0ht6HZxkzOOm0wvfPr9gjzr7ZDw4OZekB8nn74fny3Pv5x-Pm7Ol04okZfStUI6gWzlmGh7zmuntVCV0mBdzxx2su2U1s4pqCT2smZSQNsBWmDSab4g7695N3M7YudKl5MdzGbyo53-mmi9uf8S_C-zjleGAWhVMSgMb24YpvhnxpTN6JPDYbAB45xMVQPIaqXKBBfk9QPoZZynUPSZ0rGWQrAablFrO6DxoY_lY7clNY0SssirJSuow0dQZXc4ehcD9r7k7xW8vS5wU0xpwn4nkoHZWsLcWqKAX90dyw763wD8H2CDrs8</recordid><startdate>20230404</startdate><enddate>20230404</enddate><creator>Somoza-Moncada, María Montserrat</creator><creator>Turrubiates-Hernández, Francisco Javier</creator><creator>Muñoz-Valle, José Francisco</creator><creator>Gutiérrez-Brito, Jesús Alberto</creator><creator>Díaz-Pérez, Saúl Alberto</creator><creator>Aguayo-Arelis, Adriana</creator><creator>Hernández-Bello, Jorge</creator><general>MDPI AG</general><general>MDPI</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7TS</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>COVID</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0003-3225-5174</orcidid><orcidid>https://orcid.org/0000-0001-9637-168X</orcidid><orcidid>https://orcid.org/0009-0002-4065-0414</orcidid><orcidid>https://orcid.org/0000-0002-2272-9260</orcidid><orcidid>https://orcid.org/0000-0001-8004-1811</orcidid></search><sort><creationdate>20230404</creationdate><title>Vitamin D in Depression: A Potential Bioactive Agent to Reduce Suicide and Suicide Attempt Risk</title><author>Somoza-Moncada, María Montserrat ; 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| subjects | Alfacalcidol Biomarkers Brain Calcifediol Calciferol Complications and side effects Depression - drug therapy Diet therapy Dietary supplements Health aspects Humans Inflammation Major depressive disorder Mental depression Mental disorders Mental health Metabolism Metabolites Prevention Public health Review Risk factors Self destructive behavior Serotonin Suicidal behavior Suicidal Ideation Suicide Suicide, Attempted Suicides & suicide attempts Transcription factors Vitamin D Vitamin D - therapeutic use Vitamin D deficiency Vitamin D Deficiency - complications Vitamin D Deficiency - drug therapy Vitamin deficiency Vitamins - therapeutic use |
| title | Vitamin D in Depression: A Potential Bioactive Agent to Reduce Suicide and Suicide Attempt Risk |
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