Extensively Hydrolyzed Formula Improves Allergic Symptoms in the Short Term in Infants with Suspected Cow's Milk Protein Allergy
Although extensively hydrolyzed formula is widely accepted for managing cow's milk protein allergy (CMPA) long-term, there is a lack of evidence on its short-term efficacy. This study's objective was to investigate the short-term symptom changes (within 3-6 weeks) of infants diagnosed with...
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| Veröffentlicht in: | Nutrients 2023-03, Vol.15 (7), p.1677 |
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| creator | Wilsey, Michael J Florio, Jared Beacker, Jesse Lamos, Luke Baran, Jessica V Oliveros, Lea Sriaroon, Panida Brown, Jerry M Vanderhoof, Jon A |
| description | Although extensively hydrolyzed formula is widely accepted for managing cow's milk protein allergy (CMPA) long-term, there is a lack of evidence on its short-term efficacy. This study's objective was to investigate the short-term symptom changes (within 3-6 weeks) of infants diagnosed with CMPA and managed with extensively hydrolyzed formula containing Lactobacillus
at their subsequent physician visit. Healthcare providers treating 202 patients diagnosed with CMPA under six months old completed de-identified surveys, which were then analyzed in this prospective study. After their first visit, the patients were started on extensively hydrolyzed formula, and their baseline symptoms were scored on a severity scale of 0-3. Patients were then reevaluated at their next follow-up visit to assess changes in symptom severity. The study found statistically significant improvements in gastrointestinal (93%), skin (83%), respiratory (73%), and uncategorized symptoms (90%). These symptom improvements were consistent across different follow-up visit durations. This study is the largest prospective analysis conducted in the United States evaluating short-term change in CMPA symptoms severity in infants under six months old using extensively hydrolyzed formula. These findings suggest that extensively hydrolyzed formula is associated with clinical symptom relief, which is often noticeable by the next follow-up visit. However, additional randomized control trials are needed to validate these results. |
| doi_str_mv | 10.3390/nu15071677 |
| format | Article |
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at their subsequent physician visit. Healthcare providers treating 202 patients diagnosed with CMPA under six months old completed de-identified surveys, which were then analyzed in this prospective study. After their first visit, the patients were started on extensively hydrolyzed formula, and their baseline symptoms were scored on a severity scale of 0-3. Patients were then reevaluated at their next follow-up visit to assess changes in symptom severity. The study found statistically significant improvements in gastrointestinal (93%), skin (83%), respiratory (73%), and uncategorized symptoms (90%). These symptom improvements were consistent across different follow-up visit durations. This study is the largest prospective analysis conducted in the United States evaluating short-term change in CMPA symptoms severity in infants under six months old using extensively hydrolyzed formula. These findings suggest that extensively hydrolyzed formula is associated with clinical symptom relief, which is often noticeable by the next follow-up visit. However, additional randomized control trials are needed to validate these results.</description><identifier>ISSN: 2072-6643</identifier><identifier>EISSN: 2072-6643</identifier><identifier>DOI: 10.3390/nu15071677</identifier><identifier>PMID: 37049517</identifier><language>eng</language><publisher>Switzerland: MDPI AG</publisher><subject>Allergies ; Animals ; Breastfeeding & lactation ; Cattle ; Clinical trials ; Cow's milk ; Data collection ; Diet therapy ; Families & family life ; Female ; Food allergies ; Gastroenterology ; Gastrointestinal Tract ; Health aspects ; Humans ; Hypersensitivity ; Immunoglobulin E ; Infant ; Infant Formula - chemistry ; Infant formulas ; Infants ; Lacticaseibacillus rhamnosus ; Milk ; Milk allergy ; Milk Hypersensitivity - diagnosis ; Milk Hypersensitivity - therapy ; Milk Proteins ; Nutritional aspects ; Patients ; Pediatric research ; Pediatrics ; Prospective Studies ; Protein hydrolysates ; Proteins ; Statistical analysis</subject><ispartof>Nutrients, 2023-03, Vol.15 (7), p.1677</ispartof><rights>COPYRIGHT 2023 MDPI AG</rights><rights>2023 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>2023 by the authors. 2023</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c474t-d3982e21851db4d0afe0e579a96e5478794bd4bbc415af08e149b7d89c7c9d413</citedby><cites>FETCH-LOGICAL-c474t-d3982e21851db4d0afe0e579a96e5478794bd4bbc415af08e149b7d89c7c9d413</cites><orcidid>0000-0002-5601-8934 ; 0000-0002-7714-5502</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC10096968/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC10096968/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,881,27901,27902,53766,53768</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/37049517$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Wilsey, Michael J</creatorcontrib><creatorcontrib>Florio, Jared</creatorcontrib><creatorcontrib>Beacker, Jesse</creatorcontrib><creatorcontrib>Lamos, Luke</creatorcontrib><creatorcontrib>Baran, Jessica V</creatorcontrib><creatorcontrib>Oliveros, Lea</creatorcontrib><creatorcontrib>Sriaroon, Panida</creatorcontrib><creatorcontrib>Brown, Jerry M</creatorcontrib><creatorcontrib>Vanderhoof, Jon A</creatorcontrib><title>Extensively Hydrolyzed Formula Improves Allergic Symptoms in the Short Term in Infants with Suspected Cow's Milk Protein Allergy</title><title>Nutrients</title><addtitle>Nutrients</addtitle><description>Although extensively hydrolyzed formula is widely accepted for managing cow's milk protein allergy (CMPA) long-term, there is a lack of evidence on its short-term efficacy. This study's objective was to investigate the short-term symptom changes (within 3-6 weeks) of infants diagnosed with CMPA and managed with extensively hydrolyzed formula containing Lactobacillus
at their subsequent physician visit. Healthcare providers treating 202 patients diagnosed with CMPA under six months old completed de-identified surveys, which were then analyzed in this prospective study. After their first visit, the patients were started on extensively hydrolyzed formula, and their baseline symptoms were scored on a severity scale of 0-3. Patients were then reevaluated at their next follow-up visit to assess changes in symptom severity. The study found statistically significant improvements in gastrointestinal (93%), skin (83%), respiratory (73%), and uncategorized symptoms (90%). These symptom improvements were consistent across different follow-up visit durations. This study is the largest prospective analysis conducted in the United States evaluating short-term change in CMPA symptoms severity in infants under six months old using extensively hydrolyzed formula. These findings suggest that extensively hydrolyzed formula is associated with clinical symptom relief, which is often noticeable by the next follow-up visit. 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This study's objective was to investigate the short-term symptom changes (within 3-6 weeks) of infants diagnosed with CMPA and managed with extensively hydrolyzed formula containing Lactobacillus
at their subsequent physician visit. Healthcare providers treating 202 patients diagnosed with CMPA under six months old completed de-identified surveys, which were then analyzed in this prospective study. After their first visit, the patients were started on extensively hydrolyzed formula, and their baseline symptoms were scored on a severity scale of 0-3. Patients were then reevaluated at their next follow-up visit to assess changes in symptom severity. The study found statistically significant improvements in gastrointestinal (93%), skin (83%), respiratory (73%), and uncategorized symptoms (90%). These symptom improvements were consistent across different follow-up visit durations. This study is the largest prospective analysis conducted in the United States evaluating short-term change in CMPA symptoms severity in infants under six months old using extensively hydrolyzed formula. These findings suggest that extensively hydrolyzed formula is associated with clinical symptom relief, which is often noticeable by the next follow-up visit. However, additional randomized control trials are needed to validate these results.</abstract><cop>Switzerland</cop><pub>MDPI AG</pub><pmid>37049517</pmid><doi>10.3390/nu15071677</doi><orcidid>https://orcid.org/0000-0002-5601-8934</orcidid><orcidid>https://orcid.org/0000-0002-7714-5502</orcidid><oa>free_for_read</oa></addata></record> |
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| subjects | Allergies Animals Breastfeeding & lactation Cattle Clinical trials Cow's milk Data collection Diet therapy Families & family life Female Food allergies Gastroenterology Gastrointestinal Tract Health aspects Humans Hypersensitivity Immunoglobulin E Infant Infant Formula - chemistry Infant formulas Infants Lacticaseibacillus rhamnosus Milk Milk allergy Milk Hypersensitivity - diagnosis Milk Hypersensitivity - therapy Milk Proteins Nutritional aspects Patients Pediatric research Pediatrics Prospective Studies Protein hydrolysates Proteins Statistical analysis |
| title | Extensively Hydrolyzed Formula Improves Allergic Symptoms in the Short Term in Infants with Suspected Cow's Milk Protein Allergy |
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