Determinants of Lipid Parameters in Patients without Diagnosed Cardiovascular Disease-Results of the Polish Arm of the EUROASPIRE V Survey

To assess the determinants of lipid parameters in primary care patients without diagnosed cardiovascular disease (CVD), a cross-sectional study was conducted during 2018-2019 with a total of 200 patients. The following lipid parameters were measured: total cholesterol (TC), low-density lipoprotein c...

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Veröffentlicht in:Journal of clinical medicine 2023-04, Vol.12 (7), p.2738
Hauptverfasser: Ratajczak, Jakub, Kubica, Aldona, Michalski, Piotr, Pietrzykowski, Łukasz, Białczyk, Aleksandra, Kosobucka-Ozdoba, Agata, Bergmann, Katarzyna, Buczkowski, Krzysztof, Krintus, Magdalena, Jankowski, Piotr, Kubica, Jacek
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container_issue 7
container_start_page 2738
container_title Journal of clinical medicine
container_volume 12
creator Ratajczak, Jakub
Kubica, Aldona
Michalski, Piotr
Pietrzykowski, Łukasz
Białczyk, Aleksandra
Kosobucka-Ozdoba, Agata
Bergmann, Katarzyna
Buczkowski, Krzysztof
Krintus, Magdalena
Jankowski, Piotr
Kubica, Jacek
description To assess the determinants of lipid parameters in primary care patients without diagnosed cardiovascular disease (CVD), a cross-sectional study was conducted during 2018-2019 with a total of 200 patients. The following lipid parameters were measured: total cholesterol (TC), low-density lipoprotein cholesterol (LDL-C), high-density lipoprotein cholesterol (HDL-C), triglycerides (TG), small, dense LDL (sdLDL-C), and lipoprotein (a) (Lp(a)). Predictors of elevated and adequately controlled lipid parameters were assessed with logistic regression analysis. Older age was related to higher risk of TC ≥ 6.2 mmol/L [OR 1.03 (95% CI 1.0-1.05)], sdLDL-C ≥ 1.0 mmol/L [OR 1.05 (95% CI 1.0-1.1)], and decreased risk of Lp(a) ≥ 50 mg/dL [OR 0.97 (95% CI 0.94-0.99)]. Patients with diabetes mellitus (DM) had increased probability of TG ≥ 2.25 mmol/L [OR 3.77 (95% CI 1.34-10.6)] and Lp(a) ≥ 50 mg/dL [OR 2.97 (1.34-6.10)] as well as adequate control of TG and Lp(a). Higher material status was related to lower risk of TC ≥ 6.2 mmol/L [OR 0.19 (95% CI 0.04-0.82)] and LDL-C ≥ 3.6 mmol/L [OR 0.33 (95% CI 0.12-0.92)]. High BMI was related to increased [OR 1.14 (95% CI 1.02-1.29)], and female gender [OR 0.33 (95% CI 0.12-0.96)] and hypertension [OR 0.29 (95% CI 0.1-0.87)] to decreased risk of TG ≥ 2.25 mmol/L [OR 1.14 (95% CI 1.02-1.29)]. Taking lipid-lowering drugs (LLD) was associated with LDL-C < 2.6 mmol/L [OR 2.1 (95% CI 1.05-4.19)] and Lp(a) < 30 mg/dL [OR 0.48 (95% CI 0.25-0.93)]. Physical activity was related to LDL-C < 2.6 mmol/L [OR 2.02 (95% CI 1.02-3.98)]. Higher abdominal circumference was associated with decreased risk of TG < 1.7 mmol/L [OR 0.96 (95% CI 0.93-0.99)]. Elevated lipid parameters were related to age, gender, material status, BMI, history of DM, and hypertension. Adequate control was associated with age, education, physical activity, LLD, history of DM, and abdominal circumference.
doi_str_mv 10.3390/jcm12072738
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The following lipid parameters were measured: total cholesterol (TC), low-density lipoprotein cholesterol (LDL-C), high-density lipoprotein cholesterol (HDL-C), triglycerides (TG), small, dense LDL (sdLDL-C), and lipoprotein (a) (Lp(a)). Predictors of elevated and adequately controlled lipid parameters were assessed with logistic regression analysis. Older age was related to higher risk of TC ≥ 6.2 mmol/L [OR 1.03 (95% CI 1.0-1.05)], sdLDL-C ≥ 1.0 mmol/L [OR 1.05 (95% CI 1.0-1.1)], and decreased risk of Lp(a) ≥ 50 mg/dL [OR 0.97 (95% CI 0.94-0.99)]. Patients with diabetes mellitus (DM) had increased probability of TG ≥ 2.25 mmol/L [OR 3.77 (95% CI 1.34-10.6)] and Lp(a) ≥ 50 mg/dL [OR 2.97 (1.34-6.10)] as well as adequate control of TG and Lp(a). Higher material status was related to lower risk of TC ≥ 6.2 mmol/L [OR 0.19 (95% CI 0.04-0.82)] and LDL-C ≥ 3.6 mmol/L [OR 0.33 (95% CI 0.12-0.92)]. High BMI was related to increased [OR 1.14 (95% CI 1.02-1.29)], and female gender [OR 0.33 (95% CI 0.12-0.96)] and hypertension [OR 0.29 (95% CI 0.1-0.87)] to decreased risk of TG ≥ 2.25 mmol/L [OR 1.14 (95% CI 1.02-1.29)]. Taking lipid-lowering drugs (LLD) was associated with LDL-C &lt; 2.6 mmol/L [OR 2.1 (95% CI 1.05-4.19)] and Lp(a) &lt; 30 mg/dL [OR 0.48 (95% CI 0.25-0.93)]. Physical activity was related to LDL-C &lt; 2.6 mmol/L [OR 2.02 (95% CI 1.02-3.98)]. Higher abdominal circumference was associated with decreased risk of TG &lt; 1.7 mmol/L [OR 0.96 (95% CI 0.93-0.99)]. Elevated lipid parameters were related to age, gender, material status, BMI, history of DM, and hypertension. Adequate control was associated with age, education, physical activity, LLD, history of DM, and abdominal circumference.</description><identifier>ISSN: 2077-0383</identifier><identifier>EISSN: 2077-0383</identifier><identifier>DOI: 10.3390/jcm12072738</identifier><identifier>PMID: 37048821</identifier><language>eng</language><publisher>Switzerland: MDPI AG</publisher><subject>Abdomen ; Blood lipids ; Blood pressure ; Body mass index ; Cholesterol ; Clinical medicine ; Control ; Creatinine ; Demographic aspects ; Glucose ; High density lipoprotein ; Hyperlipidemia ; Laboratories ; Lipids ; Lipoproteins ; Metabolic disorders ; Obesity ; Primary care ; Regression analysis ; Risk factors ; Statins ; Triglycerides</subject><ispartof>Journal of clinical medicine, 2023-04, Vol.12 (7), p.2738</ispartof><rights>COPYRIGHT 2023 MDPI AG</rights><rights>2023 by the authors. Licensee MDPI, Basel, Switzerland. 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The following lipid parameters were measured: total cholesterol (TC), low-density lipoprotein cholesterol (LDL-C), high-density lipoprotein cholesterol (HDL-C), triglycerides (TG), small, dense LDL (sdLDL-C), and lipoprotein (a) (Lp(a)). Predictors of elevated and adequately controlled lipid parameters were assessed with logistic regression analysis. Older age was related to higher risk of TC ≥ 6.2 mmol/L [OR 1.03 (95% CI 1.0-1.05)], sdLDL-C ≥ 1.0 mmol/L [OR 1.05 (95% CI 1.0-1.1)], and decreased risk of Lp(a) ≥ 50 mg/dL [OR 0.97 (95% CI 0.94-0.99)]. Patients with diabetes mellitus (DM) had increased probability of TG ≥ 2.25 mmol/L [OR 3.77 (95% CI 1.34-10.6)] and Lp(a) ≥ 50 mg/dL [OR 2.97 (1.34-6.10)] as well as adequate control of TG and Lp(a). Higher material status was related to lower risk of TC ≥ 6.2 mmol/L [OR 0.19 (95% CI 0.04-0.82)] and LDL-C ≥ 3.6 mmol/L [OR 0.33 (95% CI 0.12-0.92)]. High BMI was related to increased [OR 1.14 (95% CI 1.02-1.29)], and female gender [OR 0.33 (95% CI 0.12-0.96)] and hypertension [OR 0.29 (95% CI 0.1-0.87)] to decreased risk of TG ≥ 2.25 mmol/L [OR 1.14 (95% CI 1.02-1.29)]. Taking lipid-lowering drugs (LLD) was associated with LDL-C &lt; 2.6 mmol/L [OR 2.1 (95% CI 1.05-4.19)] and Lp(a) &lt; 30 mg/dL [OR 0.48 (95% CI 0.25-0.93)]. Physical activity was related to LDL-C &lt; 2.6 mmol/L [OR 2.02 (95% CI 1.02-3.98)]. Higher abdominal circumference was associated with decreased risk of TG &lt; 1.7 mmol/L [OR 0.96 (95% CI 0.93-0.99)]. Elevated lipid parameters were related to age, gender, material status, BMI, history of DM, and hypertension. Adequate control was associated with age, education, physical activity, LLD, history of DM, and abdominal circumference.</description><subject>Abdomen</subject><subject>Blood lipids</subject><subject>Blood pressure</subject><subject>Body mass index</subject><subject>Cholesterol</subject><subject>Clinical medicine</subject><subject>Control</subject><subject>Creatinine</subject><subject>Demographic aspects</subject><subject>Glucose</subject><subject>High density lipoprotein</subject><subject>Hyperlipidemia</subject><subject>Laboratories</subject><subject>Lipids</subject><subject>Lipoproteins</subject><subject>Metabolic disorders</subject><subject>Obesity</subject><subject>Primary care</subject><subject>Regression analysis</subject><subject>Risk factors</subject><subject>Statins</subject><subject>Triglycerides</subject><issn>2077-0383</issn><issn>2077-0383</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2023</creationdate><recordtype>article</recordtype><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><recordid>eNptUk1rGzEQXUpLE9Kcei-CXgplU32tJZ2Kcdw0YIhxml6Fdndky-yuXGnXJX-hvzpanKRO6eig0bw3b3hisuw9wReMKfxlW7WEYkEFk6-y05SJHDPJXh_lJ9l5jFucQkpOiXibnTCBuZSUnGZ_LqGH0LrOdH1E3qKF27kaLU0w7YhE5Lr06h2M-G_Xb_zQo0tn1p2PUKOZCbXzexOroTEhARFMhHwFcWgOgv0G0NI3Lm7QNLRPlfnd6mZ6u7xezdFPdDuEPdy_y95Y00Q4f7zPsrtv8x-z7_ni5up6Nl3kFReiz0lJlSoKXlLAhZTWUiInFJfcWGYLqUwt2EQqWUAKS5ixvCSqpqYgUNaGs7Ps60F3N5Qt1FVyFkyjd8G1Jtxrb5x-iXRuo9d-rwnGquCKJYVPjwrB_xog9rp1sYKmMR34IWoqMZ5QVhCRqB__oW79ELrkT1Oh1ISzZOYva20a0K6zPg2uRlE9FQVmmFI-si7-w0qnhtZVvgPrUv1Fw-dDQxV8jAHss0mC9bg--mh9EvvD8b88c5-WhT0ALC-_mg</recordid><startdate>20230406</startdate><enddate>20230406</enddate><creator>Ratajczak, Jakub</creator><creator>Kubica, Aldona</creator><creator>Michalski, Piotr</creator><creator>Pietrzykowski, Łukasz</creator><creator>Białczyk, Aleksandra</creator><creator>Kosobucka-Ozdoba, Agata</creator><creator>Bergmann, Katarzyna</creator><creator>Buczkowski, Krzysztof</creator><creator>Krintus, Magdalena</creator><creator>Jankowski, Piotr</creator><creator>Kubica, Jacek</creator><general>MDPI AG</general><general>MDPI</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>M0S</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0001-7798-3138</orcidid><orcidid>https://orcid.org/0000-0001-9912-0325</orcidid><orcidid>https://orcid.org/0000-0001-8250-754X</orcidid><orcidid>https://orcid.org/0000-0002-3059-5338</orcidid><orcidid>https://orcid.org/0000-0002-1368-3475</orcidid><orcidid>https://orcid.org/0000-0001-6223-8821</orcidid><orcidid>https://orcid.org/0000-0001-9667-6096</orcidid><orcidid>https://orcid.org/0000-0002-7700-0952</orcidid><orcidid>https://orcid.org/0000-0003-4735-2356</orcidid></search><sort><creationdate>20230406</creationdate><title>Determinants of Lipid Parameters in Patients without Diagnosed Cardiovascular Disease-Results of the Polish Arm of the EUROASPIRE V Survey</title><author>Ratajczak, Jakub ; Kubica, Aldona ; Michalski, Piotr ; Pietrzykowski, Łukasz ; Białczyk, Aleksandra ; Kosobucka-Ozdoba, Agata ; Bergmann, Katarzyna ; Buczkowski, Krzysztof ; Krintus, Magdalena ; Jankowski, Piotr ; Kubica, Jacek</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c477t-1b299554b2e0588ff218620b4af3f589ad7368985eeeef13af4b19d2a51ebda43</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2023</creationdate><topic>Abdomen</topic><topic>Blood lipids</topic><topic>Blood pressure</topic><topic>Body mass index</topic><topic>Cholesterol</topic><topic>Clinical medicine</topic><topic>Control</topic><topic>Creatinine</topic><topic>Demographic aspects</topic><topic>Glucose</topic><topic>High density lipoprotein</topic><topic>Hyperlipidemia</topic><topic>Laboratories</topic><topic>Lipids</topic><topic>Lipoproteins</topic><topic>Metabolic disorders</topic><topic>Obesity</topic><topic>Primary care</topic><topic>Regression analysis</topic><topic>Risk factors</topic><topic>Statins</topic><topic>Triglycerides</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Ratajczak, Jakub</creatorcontrib><creatorcontrib>Kubica, Aldona</creatorcontrib><creatorcontrib>Michalski, Piotr</creatorcontrib><creatorcontrib>Pietrzykowski, Łukasz</creatorcontrib><creatorcontrib>Białczyk, Aleksandra</creatorcontrib><creatorcontrib>Kosobucka-Ozdoba, Agata</creatorcontrib><creatorcontrib>Bergmann, Katarzyna</creatorcontrib><creatorcontrib>Buczkowski, Krzysztof</creatorcontrib><creatorcontrib>Krintus, Magdalena</creatorcontrib><creatorcontrib>Jankowski, Piotr</creatorcontrib><creatorcontrib>Kubica, Jacek</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health &amp; 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The following lipid parameters were measured: total cholesterol (TC), low-density lipoprotein cholesterol (LDL-C), high-density lipoprotein cholesterol (HDL-C), triglycerides (TG), small, dense LDL (sdLDL-C), and lipoprotein (a) (Lp(a)). Predictors of elevated and adequately controlled lipid parameters were assessed with logistic regression analysis. Older age was related to higher risk of TC ≥ 6.2 mmol/L [OR 1.03 (95% CI 1.0-1.05)], sdLDL-C ≥ 1.0 mmol/L [OR 1.05 (95% CI 1.0-1.1)], and decreased risk of Lp(a) ≥ 50 mg/dL [OR 0.97 (95% CI 0.94-0.99)]. Patients with diabetes mellitus (DM) had increased probability of TG ≥ 2.25 mmol/L [OR 3.77 (95% CI 1.34-10.6)] and Lp(a) ≥ 50 mg/dL [OR 2.97 (1.34-6.10)] as well as adequate control of TG and Lp(a). Higher material status was related to lower risk of TC ≥ 6.2 mmol/L [OR 0.19 (95% CI 0.04-0.82)] and LDL-C ≥ 3.6 mmol/L [OR 0.33 (95% CI 0.12-0.92)]. High BMI was related to increased [OR 1.14 (95% CI 1.02-1.29)], and female gender [OR 0.33 (95% CI 0.12-0.96)] and hypertension [OR 0.29 (95% CI 0.1-0.87)] to decreased risk of TG ≥ 2.25 mmol/L [OR 1.14 (95% CI 1.02-1.29)]. Taking lipid-lowering drugs (LLD) was associated with LDL-C &lt; 2.6 mmol/L [OR 2.1 (95% CI 1.05-4.19)] and Lp(a) &lt; 30 mg/dL [OR 0.48 (95% CI 0.25-0.93)]. Physical activity was related to LDL-C &lt; 2.6 mmol/L [OR 2.02 (95% CI 1.02-3.98)]. Higher abdominal circumference was associated with decreased risk of TG &lt; 1.7 mmol/L [OR 0.96 (95% CI 0.93-0.99)]. Elevated lipid parameters were related to age, gender, material status, BMI, history of DM, and hypertension. 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source Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; PubMed Central Open Access; MDPI - Multidisciplinary Digital Publishing Institute; PubMed Central
subjects Abdomen
Blood lipids
Blood pressure
Body mass index
Cholesterol
Clinical medicine
Control
Creatinine
Demographic aspects
Glucose
High density lipoprotein
Hyperlipidemia
Laboratories
Lipids
Lipoproteins
Metabolic disorders
Obesity
Primary care
Regression analysis
Risk factors
Statins
Triglycerides
title Determinants of Lipid Parameters in Patients without Diagnosed Cardiovascular Disease-Results of the Polish Arm of the EUROASPIRE V Survey
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