Electrophysiological Properties of Tetraploid Cardiomyocytes Derived from Murine Pluripotent Stem Cells Generated by Fusion of Adult Somatic Cells with Embryonic Stem Cells

Most cardiomyocytes (CMs) in the adult mammalian heart are either binucleated or contain a single polyploid nucleus. Recent studies have shown that polyploidy in CMs plays an important role as an adaptive response to physiological demands and environmental stress and correlates with poor cardiac reg...

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Veröffentlicht in:	International journal of molecular sciences 2023-03, Vol.24 (7), p.6546
Hauptverfasser:	Xu, Guoxing, Fatima, Azra, Breitbach, Martin, Kuzmenkin, Alexey, Fügemann, Christopher J, Ivanyuk, Dina, Kim, Kee Pyo, Cantz, Tobias, Pfannkuche, Kurt, Schöler, Hans R, Fleischmann, Bernd K, Hescheler, Jürgen, Šarić, Tomo
Format:	Artikel
Sprache:	eng
Schlagworte:	Action potential Analysis Animals Bone marrow Cardiomyocytes Cell cycle Cell differentiation Cell Differentiation - genetics Cell fusion Chromosomes Cloning Comparative analysis Diploids Diploidy Embryo cells Embryonic Stem Cells Environmental stress Epigenetics Fibroblasts Gene expression Genomes Genomics Haplotypes Heart Heart cells Induced Pluripotent Stem Cells Ion channels Mammals Mice Myocytes, Cardiac - metabolism Physiological aspects Physiology Ploidy Pluripotency Pluripotent Stem Cells Polyploidy Somatic cells Stem cells Tetraploidy
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