RanBP1: A Potential Therapeutic Target for Cancer Stem Cells in Lung Cancer and Glioma
Cancer stem cells (CSCs) are known to be one of the factors that make cancer treatment difficult. Many researchers are thus conducting research to efficiently destroy CSCs. Therefore, we sought to suggest a new target that can efficiently suppress CSCs. In this study, we observed a high expression o...
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| Veröffentlicht in: | International journal of molecular sciences 2023-04, Vol.24 (7), p.6855 |
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| description | Cancer stem cells (CSCs) are known to be one of the factors that make cancer treatment difficult. Many researchers are thus conducting research to efficiently destroy CSCs. Therefore, we sought to suggest a new target that can efficiently suppress CSCs. In this study, we observed a high expression of Ran-binding protein 1 (RanBP1) in lung cancer stem cells (LCSCs) and glioma stem cells (GSCs). Upregulated RanBP1 expression is strongly associated with the expression of CSC marker proteins and CSC regulators. In addition, an elevated RanBP1 expression is strongly associated with a poor patient prognosis. CSCs have the ability to resist radiation, and RanBP1 regulates this ability. RanBP1 also affects the metastasis-associated epithelial-mesenchymal transition (EMT) phenomenon. EMT marker proteins and regulatory proteins are affected by RanBP1 expression, and cell motility was regulated according to RanBP1 expression. The cancer microenvironment influences cancer growth, metastasis, and cancer treatment. RanBP1 can modulate the cancer microenvironment by regulating the cytokine IL-18. Secreted IL-18 acts on cancer cells and promotes cancer malignancy. Our results reveal, for the first time, that RanBP1 is an important regulator in LCSCs and GSCs, suggesting that it holds potential for use as a potential therapeutic target. |
| doi_str_mv | 10.3390/ijms24076855 |
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Many researchers are thus conducting research to efficiently destroy CSCs. Therefore, we sought to suggest a new target that can efficiently suppress CSCs. In this study, we observed a high expression of Ran-binding protein 1 (RanBP1) in lung cancer stem cells (LCSCs) and glioma stem cells (GSCs). Upregulated RanBP1 expression is strongly associated with the expression of CSC marker proteins and CSC regulators. In addition, an elevated RanBP1 expression is strongly associated with a poor patient prognosis. CSCs have the ability to resist radiation, and RanBP1 regulates this ability. RanBP1 also affects the metastasis-associated epithelial-mesenchymal transition (EMT) phenomenon. EMT marker proteins and regulatory proteins are affected by RanBP1 expression, and cell motility was regulated according to RanBP1 expression. The cancer microenvironment influences cancer growth, metastasis, and cancer treatment. RanBP1 can modulate the cancer microenvironment by regulating the cytokine IL-18. Secreted IL-18 acts on cancer cells and promotes cancer malignancy. Our results reveal, for the first time, that RanBP1 is an important regulator in LCSCs and GSCs, suggesting that it holds potential for use as a potential therapeutic target.</description><identifier>ISSN: 1422-0067</identifier><identifier>ISSN: 1661-6596</identifier><identifier>EISSN: 1422-0067</identifier><identifier>DOI: 10.3390/ijms24076855</identifier><identifier>PMID: 37047826</identifier><language>eng</language><publisher>Switzerland: MDPI AG</publisher><subject>Antibodies ; Cancer ; Care and treatment ; Cell adhesion & migration ; Cell Line, Tumor ; Cytokines ; Epithelial-Mesenchymal Transition ; Gene expression ; Glioma ; Glioma - metabolism ; Glioma cells ; Gliomas ; Health aspects ; Humans ; Interleukin 18 ; Interleukin-18 - metabolism ; Lung cancer ; Lung Neoplasms - metabolism ; Malignancy ; Metastases ; Metastasis ; Microenvironments ; Motility ; Neoplastic Stem Cells - metabolism ; Oncology, Experimental ; Protein binding ; Protein expression ; Proteins ; Radiation ; Ran-binding protein ; Regulatory proteins ; Scientific equipment and supplies industry ; Spheres ; Stem cells ; Therapeutic applications ; Therapeutic targets ; Tumor Microenvironment</subject><ispartof>International journal of molecular sciences, 2023-04, Vol.24 (7), p.6855</ispartof><rights>COPYRIGHT 2023 MDPI AG</rights><rights>2023 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>2023 by the authors. 2023</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c480t-534c813705cdbbe20a2df60d8fa332464eea7d732ce315b4fc186b15d78c14e13</citedby><cites>FETCH-LOGICAL-c480t-534c813705cdbbe20a2df60d8fa332464eea7d732ce315b4fc186b15d78c14e13</cites><orcidid>0000-0001-6607-4449 ; 0000-0002-5102-8885</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC10095367/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC10095367/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,881,27901,27902,53766,53768</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/37047826$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Kahm, Yeon-Jee</creatorcontrib><creatorcontrib>Kim, In-Gyu</creatorcontrib><creatorcontrib>Kim, Rae-Kwon</creatorcontrib><title>RanBP1: A Potential Therapeutic Target for Cancer Stem Cells in Lung Cancer and Glioma</title><title>International journal of molecular sciences</title><addtitle>Int J Mol Sci</addtitle><description>Cancer stem cells (CSCs) are known to be one of the factors that make cancer treatment difficult. Many researchers are thus conducting research to efficiently destroy CSCs. Therefore, we sought to suggest a new target that can efficiently suppress CSCs. In this study, we observed a high expression of Ran-binding protein 1 (RanBP1) in lung cancer stem cells (LCSCs) and glioma stem cells (GSCs). Upregulated RanBP1 expression is strongly associated with the expression of CSC marker proteins and CSC regulators. In addition, an elevated RanBP1 expression is strongly associated with a poor patient prognosis. CSCs have the ability to resist radiation, and RanBP1 regulates this ability. RanBP1 also affects the metastasis-associated epithelial-mesenchymal transition (EMT) phenomenon. EMT marker proteins and regulatory proteins are affected by RanBP1 expression, and cell motility was regulated according to RanBP1 expression. The cancer microenvironment influences cancer growth, metastasis, and cancer treatment. RanBP1 can modulate the cancer microenvironment by regulating the cytokine IL-18. Secreted IL-18 acts on cancer cells and promotes cancer malignancy. Our results reveal, for the first time, that RanBP1 is an important regulator in LCSCs and GSCs, suggesting that it holds potential for use as a potential therapeutic target.</description><subject>Antibodies</subject><subject>Cancer</subject><subject>Care and treatment</subject><subject>Cell adhesion & migration</subject><subject>Cell Line, Tumor</subject><subject>Cytokines</subject><subject>Epithelial-Mesenchymal Transition</subject><subject>Gene expression</subject><subject>Glioma</subject><subject>Glioma - metabolism</subject><subject>Glioma cells</subject><subject>Gliomas</subject><subject>Health aspects</subject><subject>Humans</subject><subject>Interleukin 18</subject><subject>Interleukin-18 - metabolism</subject><subject>Lung cancer</subject><subject>Lung Neoplasms - metabolism</subject><subject>Malignancy</subject><subject>Metastases</subject><subject>Metastasis</subject><subject>Microenvironments</subject><subject>Motility</subject><subject>Neoplastic Stem Cells - metabolism</subject><subject>Oncology, Experimental</subject><subject>Protein binding</subject><subject>Protein expression</subject><subject>Proteins</subject><subject>Radiation</subject><subject>Ran-binding protein</subject><subject>Regulatory proteins</subject><subject>Scientific equipment and supplies industry</subject><subject>Spheres</subject><subject>Stem cells</subject><subject>Therapeutic applications</subject><subject>Therapeutic targets</subject><subject>Tumor Microenvironment</subject><issn>1422-0067</issn><issn>1661-6596</issn><issn>1422-0067</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2023</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>8G5</sourceid><sourceid>BENPR</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><recordid>eNptksuPFCEQxonRuA-9eTYkXjzsrDwb8GLGia4mk7jR0Suh6epZJt0wQreJ_71s9uGsMRwg1K--4isKoReUnHNuyJuwGwsTRDVaykfomArGFoQ06vHB-QidlLIjhHEmzVN0xBURSrPmGP346uL7S_oWL_FlmiBOwQ14cwXZ7WGegscbl7cw4T5lvHLRQ8bfJhjxCoah4BDxeo7bu4iLHb4YQhrdM_Skd0OB57f7Kfr-8cNm9Wmx_nLxebVcL7zQZFpILrym9TXSd20LjDjW9Q3pdO84Z6IRAE51ijMPnMpW9J7qpqWyU9pTAZSfonc3uvu5HaHz1UB2g93nMLr82yYX7MNIDFd2m35ZSoiRvFFV4fWtQk4_ZyiTHUPx1Z2LkOZima4NZFQSU9FX_6C7NOdY_VmmjGm0MZr9pbZuABtin2phfy1ql0pSw5TWulLn_6Hq6mAMPkXoQ71_kHB2k-BzKiVDf2-SEns9CPZwECr-8rAx9_Ddz_M_1tyr1Q</recordid><startdate>20230401</startdate><enddate>20230401</enddate><creator>Kahm, Yeon-Jee</creator><creator>Kim, In-Gyu</creator><creator>Kim, Rae-Kwon</creator><general>MDPI AG</general><general>MDPI</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>8G5</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>GUQSH</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>M2O</scope><scope>MBDVC</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>Q9U</scope><scope>7X8</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0001-6607-4449</orcidid><orcidid>https://orcid.org/0000-0002-5102-8885</orcidid></search><sort><creationdate>20230401</creationdate><title>RanBP1: A Potential Therapeutic Target for Cancer Stem Cells in Lung Cancer and Glioma</title><author>Kahm, Yeon-Jee ; Kim, In-Gyu ; Kim, Rae-Kwon</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c480t-534c813705cdbbe20a2df60d8fa332464eea7d732ce315b4fc186b15d78c14e13</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2023</creationdate><topic>Antibodies</topic><topic>Cancer</topic><topic>Care and treatment</topic><topic>Cell adhesion & migration</topic><topic>Cell Line, Tumor</topic><topic>Cytokines</topic><topic>Epithelial-Mesenchymal Transition</topic><topic>Gene expression</topic><topic>Glioma</topic><topic>Glioma - metabolism</topic><topic>Glioma cells</topic><topic>Gliomas</topic><topic>Health aspects</topic><topic>Humans</topic><topic>Interleukin 18</topic><topic>Interleukin-18 - metabolism</topic><topic>Lung cancer</topic><topic>Lung Neoplasms - metabolism</topic><topic>Malignancy</topic><topic>Metastases</topic><topic>Metastasis</topic><topic>Microenvironments</topic><topic>Motility</topic><topic>Neoplastic Stem Cells - metabolism</topic><topic>Oncology, Experimental</topic><topic>Protein binding</topic><topic>Protein expression</topic><topic>Proteins</topic><topic>Radiation</topic><topic>Ran-binding protein</topic><topic>Regulatory proteins</topic><topic>Scientific equipment and supplies industry</topic><topic>Spheres</topic><topic>Stem cells</topic><topic>Therapeutic applications</topic><topic>Therapeutic targets</topic><topic>Tumor Microenvironment</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Kahm, Yeon-Jee</creatorcontrib><creatorcontrib>Kim, In-Gyu</creatorcontrib><creatorcontrib>Kim, Rae-Kwon</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Research Library (Alumni Edition)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>Research Library Prep</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Research Library</collection><collection>Research Library (Corporate)</collection><collection>Publicly Available Content Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>ProQuest Central Basic</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>International journal of molecular sciences</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Kahm, Yeon-Jee</au><au>Kim, In-Gyu</au><au>Kim, Rae-Kwon</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>RanBP1: A Potential Therapeutic Target for Cancer Stem Cells in Lung Cancer and Glioma</atitle><jtitle>International journal of molecular sciences</jtitle><addtitle>Int J Mol Sci</addtitle><date>2023-04-01</date><risdate>2023</risdate><volume>24</volume><issue>7</issue><spage>6855</spage><pages>6855-</pages><issn>1422-0067</issn><issn>1661-6596</issn><eissn>1422-0067</eissn><abstract>Cancer stem cells (CSCs) are known to be one of the factors that make cancer treatment difficult. Many researchers are thus conducting research to efficiently destroy CSCs. Therefore, we sought to suggest a new target that can efficiently suppress CSCs. In this study, we observed a high expression of Ran-binding protein 1 (RanBP1) in lung cancer stem cells (LCSCs) and glioma stem cells (GSCs). Upregulated RanBP1 expression is strongly associated with the expression of CSC marker proteins and CSC regulators. In addition, an elevated RanBP1 expression is strongly associated with a poor patient prognosis. CSCs have the ability to resist radiation, and RanBP1 regulates this ability. RanBP1 also affects the metastasis-associated epithelial-mesenchymal transition (EMT) phenomenon. EMT marker proteins and regulatory proteins are affected by RanBP1 expression, and cell motility was regulated according to RanBP1 expression. The cancer microenvironment influences cancer growth, metastasis, and cancer treatment. RanBP1 can modulate the cancer microenvironment by regulating the cytokine IL-18. Secreted IL-18 acts on cancer cells and promotes cancer malignancy. Our results reveal, for the first time, that RanBP1 is an important regulator in LCSCs and GSCs, suggesting that it holds potential for use as a potential therapeutic target.</abstract><cop>Switzerland</cop><pub>MDPI AG</pub><pmid>37047826</pmid><doi>10.3390/ijms24076855</doi><orcidid>https://orcid.org/0000-0001-6607-4449</orcidid><orcidid>https://orcid.org/0000-0002-5102-8885</orcidid><oa>free_for_read</oa></addata></record> |
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| subjects | Antibodies Cancer Care and treatment Cell adhesion & migration Cell Line, Tumor Cytokines Epithelial-Mesenchymal Transition Gene expression Glioma Glioma - metabolism Glioma cells Gliomas Health aspects Humans Interleukin 18 Interleukin-18 - metabolism Lung cancer Lung Neoplasms - metabolism Malignancy Metastases Metastasis Microenvironments Motility Neoplastic Stem Cells - metabolism Oncology, Experimental Protein binding Protein expression Proteins Radiation Ran-binding protein Regulatory proteins Scientific equipment and supplies industry Spheres Stem cells Therapeutic applications Therapeutic targets Tumor Microenvironment |
| title | RanBP1: A Potential Therapeutic Target for Cancer Stem Cells in Lung Cancer and Glioma |
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