Curcumin and Plumbagin Synergistically Target the PI3K/Akt/mTOR Pathway: A Prospective Role in Cancer Treatment

Cancer development is associated with the deregulation of various cell signaling pathways brought on by certain genetic and epigenetic alterations. Therefore, novel therapeutic strategies have been developed to target those pathways. The phosphoinositide 3-kinase (PI3K)/protein kinase B (Akt)/mammal...

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Veröffentlicht in:	International journal of molecular sciences 2023-04, Vol.24 (7), p.6651
Hauptverfasser:	Ahmad, Iftikhar, Hoque, Mehboob, Alam, Syed Sahajada Mahafujul, Zughaibi, Torki A, Tabrez, Shams
Format:	Artikel
Sprache:	eng
Schlagworte:	1-Phosphatidylinositol 3-kinase AKT protein Analysis Apoptosis Bioactive compounds Cancer Cancer therapies Care and treatment Cell cycle Cell signaling Cellular signal transduction Combinatorial analysis Curcumin Curcumin - pharmacology Deregulation Drug development Energy Epigenetics Health aspects Humans Kinases Ligands Metastasis Molecular docking Molecular Docking Simulation Molecular dynamics Neoplasms - drug therapy Phosphatidylinositol 3-Kinase - metabolism Phosphatidylinositol 3-Kinases - metabolism Plumbagin Protein kinases Proteins Proto-Oncogene Proteins c-akt - metabolism Rapamycin Signal transduction Simulation Synergistic effect TOR protein TOR Serine-Threonine Kinases - metabolism
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