Clinical Course and Severity of COVID-19 in 940 Infants with and without Comorbidities Hospitalized in 2020 and 2021: The Results of the National Multicenter Database SARSTer-PED
This study aimed to analyze the differences in severity and clinical characteristics of COVID-19 in infants hospitalized in Poland in 2021, when the dominance of variants of concern (VOCs) alpha and delta was reported, compared to 2020, when original (wild) SARS-CoV-2 was dominant (III-IV vs. I-II w...
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| Veröffentlicht in: | Journal of clinical medicine 2023-03, Vol.12 (7), p.2479 |
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| creator | Pawłowska, Małgorzata Pokorska-Śpiewak, Maria Talarek, Ewa Mania, Anna Hasiec, Barbara Żwirek-Pytka, Elżbieta Stankiewicz, Magdalena Stani, Martyna Frańczak-Chmura, Paulina Szenborn, Leszek Zaleska, Izabela Chruszcz, Joanna Majda-Stanisławska, Ewa Dryja, Urszula Gąsiorowska, Kamila Figlerowicz, Magdalena Mazur-Melewska, Katarzyna Faltin, Kamil Ciechanowski, Przemysław Peregrym, Michał Łasecka-Zadrożna, Joanna Rudnicki, Józef Szczepańska, Barbara Pałyga-Bysiecka, Ilona Rogowska, Ewelina Hudobska-Nawrot, Dagmara Domańska-Granek, Katarzyna Sybilski, Adam Kucharek, Izabela Franczak, Justyna Sobolewska-Pilarczyk, Małgorzata Kuchar, Ernest Wronowski, Michał Paryż, Maria Kalicki, Bolesław Toczyłowski, Kacper Sulik, Artur Niedźwiecka, Sławomira Flisiak, Robert Marczyńska, Magdalena |
| description | This study aimed to analyze the differences in severity and clinical characteristics of COVID-19 in infants hospitalized in Poland in 2021, when the dominance of variants of concern (VOCs) alpha and delta was reported, compared to 2020, when original (wild) SARS-CoV-2 was dominant (III-IV vs. I-II waves of the pandemic, respectively). In addition, the influence of the presence of comorbidities on the clinical course of COVID-19 in infants was studied. This multicenter study, based on the pediatric part of the national SARSTer database (SARSTer-PED), included 940 infants with COVID-19 diagnosed between March 1, 2020, and December 31, 2021, from 13 Polish inpatient centers. An electronic questionnaire, which addressed epidemiological and clinical data, was used. The number of hospitalized infants was significantly higher in 2021 than in 2020 (651 vs. 289, respectively). The analysis showed similar lengths of infant hospitalization in 2020 and 2021, but significantly more children were hospitalized for more than 7 days in 2020 (
< 0.009). In both analyzed periods, the most common route of infection for infants was household contact. There was an increase in the percentage of comorbidities, especially prematurity, in children hospitalized in 2021 compared to 2020. Among the clinical manifestations, fever was predominant among children hospitalized in 2021 and 2020. Cough, runny nose, and loss of appetite were significantly more frequently observed in 2021 (
< 0.0001). Severe and critical conditions were significantly more common among children with comorbidities. More infants were hospitalized during the period of VOCs dominance, especially the delta variant, compared to the period of wild strain dominance, even though indications for hospitalization did not include asymptomatic patients during that period. The course of COVID-19 was mostly mild, characterized mainly by fever and respiratory symptoms. Comorbidities, particularly from the cardiovascular system and prematurity, were associated with a more severe course of the disease in infants. |
| doi_str_mv | 10.3390/jcm12072479 |
| format | Article |
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< 0.009). In both analyzed periods, the most common route of infection for infants was household contact. There was an increase in the percentage of comorbidities, especially prematurity, in children hospitalized in 2021 compared to 2020. Among the clinical manifestations, fever was predominant among children hospitalized in 2021 and 2020. Cough, runny nose, and loss of appetite were significantly more frequently observed in 2021 (
< 0.0001). Severe and critical conditions were significantly more common among children with comorbidities. More infants were hospitalized during the period of VOCs dominance, especially the delta variant, compared to the period of wild strain dominance, even though indications for hospitalization did not include asymptomatic patients during that period. The course of COVID-19 was mostly mild, characterized mainly by fever and respiratory symptoms. Comorbidities, particularly from the cardiovascular system and prematurity, were associated with a more severe course of the disease in infants.</description><identifier>ISSN: 2077-0383</identifier><identifier>EISSN: 2077-0383</identifier><identifier>DOI: 10.3390/jcm12072479</identifier><identifier>PMID: 37048562</identifier><language>eng</language><publisher>Switzerland: MDPI AG</publisher><subject>Age ; Asymptomatic ; Clinical medicine ; Coronaviruses ; COVID-19 ; Disease transmission ; Diseases ; Dyspnea ; Hospitalization ; Hospitals ; Infants (Newborn) ; Infections ; Laboratories ; Multisystem inflammatory syndrome in children ; Pandemics ; Pediatrics ; Pneumonia ; Severe acute respiratory syndrome coronavirus 2</subject><ispartof>Journal of clinical medicine, 2023-03, Vol.12 (7), p.2479</ispartof><rights>COPYRIGHT 2023 MDPI AG</rights><rights>2023 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). 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In addition, the influence of the presence of comorbidities on the clinical course of COVID-19 in infants was studied. This multicenter study, based on the pediatric part of the national SARSTer database (SARSTer-PED), included 940 infants with COVID-19 diagnosed between March 1, 2020, and December 31, 2021, from 13 Polish inpatient centers. An electronic questionnaire, which addressed epidemiological and clinical data, was used. The number of hospitalized infants was significantly higher in 2021 than in 2020 (651 vs. 289, respectively). The analysis showed similar lengths of infant hospitalization in 2020 and 2021, but significantly more children were hospitalized for more than 7 days in 2020 (
< 0.009). In both analyzed periods, the most common route of infection for infants was household contact. There was an increase in the percentage of comorbidities, especially prematurity, in children hospitalized in 2021 compared to 2020. Among the clinical manifestations, fever was predominant among children hospitalized in 2021 and 2020. Cough, runny nose, and loss of appetite were significantly more frequently observed in 2021 (
< 0.0001). Severe and critical conditions were significantly more common among children with comorbidities. More infants were hospitalized during the period of VOCs dominance, especially the delta variant, compared to the period of wild strain dominance, even though indications for hospitalization did not include asymptomatic patients during that period. The course of COVID-19 was mostly mild, characterized mainly by fever and respiratory symptoms. Comorbidities, particularly from the cardiovascular system and prematurity, were associated with a more severe course of the disease in infants.</description><subject>Age</subject><subject>Asymptomatic</subject><subject>Clinical medicine</subject><subject>Coronaviruses</subject><subject>COVID-19</subject><subject>Disease transmission</subject><subject>Diseases</subject><subject>Dyspnea</subject><subject>Hospitalization</subject><subject>Hospitals</subject><subject>Infants (Newborn)</subject><subject>Infections</subject><subject>Laboratories</subject><subject>Multisystem inflammatory syndrome in children</subject><subject>Pandemics</subject><subject>Pediatrics</subject><subject>Pneumonia</subject><subject>Severe acute respiratory syndrome coronavirus 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Michał</creatorcontrib><creatorcontrib>Łasecka-Zadrożna, Joanna</creatorcontrib><creatorcontrib>Rudnicki, Józef</creatorcontrib><creatorcontrib>Szczepańska, Barbara</creatorcontrib><creatorcontrib>Pałyga-Bysiecka, Ilona</creatorcontrib><creatorcontrib>Rogowska, Ewelina</creatorcontrib><creatorcontrib>Hudobska-Nawrot, Dagmara</creatorcontrib><creatorcontrib>Domańska-Granek, Katarzyna</creatorcontrib><creatorcontrib>Sybilski, Adam</creatorcontrib><creatorcontrib>Kucharek, Izabela</creatorcontrib><creatorcontrib>Franczak, Justyna</creatorcontrib><creatorcontrib>Sobolewska-Pilarczyk, Małgorzata</creatorcontrib><creatorcontrib>Kuchar, Ernest</creatorcontrib><creatorcontrib>Wronowski, Michał</creatorcontrib><creatorcontrib>Paryż, Maria</creatorcontrib><creatorcontrib>Kalicki, Bolesław</creatorcontrib><creatorcontrib>Toczyłowski, Kacper</creatorcontrib><creatorcontrib>Sulik, Artur</creatorcontrib><creatorcontrib>Niedźwiecka, Sławomira</creatorcontrib><creatorcontrib>Flisiak, Robert</creatorcontrib><creatorcontrib>Marczyńska, Magdalena</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>ProQuest_Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>Coronavirus Research Database</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Publicly Available Content Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Journal of clinical medicine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Pawłowska, Małgorzata</au><au>Pokorska-Śpiewak, Maria</au><au>Talarek, Ewa</au><au>Mania, Anna</au><au>Hasiec, Barbara</au><au>Żwirek-Pytka, Elżbieta</au><au>Stankiewicz, Magdalena</au><au>Stani, Martyna</au><au>Frańczak-Chmura, Paulina</au><au>Szenborn, Leszek</au><au>Zaleska, Izabela</au><au>Chruszcz, Joanna</au><au>Majda-Stanisławska, Ewa</au><au>Dryja, Urszula</au><au>Gąsiorowska, Kamila</au><au>Figlerowicz, Magdalena</au><au>Mazur-Melewska, Katarzyna</au><au>Faltin, Kamil</au><au>Ciechanowski, Przemysław</au><au>Peregrym, Michał</au><au>Łasecka-Zadrożna, Joanna</au><au>Rudnicki, Józef</au><au>Szczepańska, Barbara</au><au>Pałyga-Bysiecka, Ilona</au><au>Rogowska, Ewelina</au><au>Hudobska-Nawrot, Dagmara</au><au>Domańska-Granek, Katarzyna</au><au>Sybilski, Adam</au><au>Kucharek, Izabela</au><au>Franczak, Justyna</au><au>Sobolewska-Pilarczyk, Małgorzata</au><au>Kuchar, Ernest</au><au>Wronowski, Michał</au><au>Paryż, Maria</au><au>Kalicki, Bolesław</au><au>Toczyłowski, Kacper</au><au>Sulik, Artur</au><au>Niedźwiecka, Sławomira</au><au>Flisiak, Robert</au><au>Marczyńska, Magdalena</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Clinical Course and Severity of COVID-19 in 940 Infants with and without Comorbidities Hospitalized in 2020 and 2021: The Results of the National Multicenter Database SARSTer-PED</atitle><jtitle>Journal of clinical medicine</jtitle><addtitle>J Clin Med</addtitle><date>2023-03-24</date><risdate>2023</risdate><volume>12</volume><issue>7</issue><spage>2479</spage><pages>2479-</pages><issn>2077-0383</issn><eissn>2077-0383</eissn><abstract>This study aimed to analyze the differences in severity and clinical characteristics of COVID-19 in infants hospitalized in Poland in 2021, when the dominance of variants of concern (VOCs) alpha and delta was reported, compared to 2020, when original (wild) SARS-CoV-2 was dominant (III-IV vs. I-II waves of the pandemic, respectively). In addition, the influence of the presence of comorbidities on the clinical course of COVID-19 in infants was studied. This multicenter study, based on the pediatric part of the national SARSTer database (SARSTer-PED), included 940 infants with COVID-19 diagnosed between March 1, 2020, and December 31, 2021, from 13 Polish inpatient centers. An electronic questionnaire, which addressed epidemiological and clinical data, was used. The number of hospitalized infants was significantly higher in 2021 than in 2020 (651 vs. 289, respectively). The analysis showed similar lengths of infant hospitalization in 2020 and 2021, but significantly more children were hospitalized for more than 7 days in 2020 (
< 0.009). In both analyzed periods, the most common route of infection for infants was household contact. There was an increase in the percentage of comorbidities, especially prematurity, in children hospitalized in 2021 compared to 2020. Among the clinical manifestations, fever was predominant among children hospitalized in 2021 and 2020. Cough, runny nose, and loss of appetite were significantly more frequently observed in 2021 (
< 0.0001). Severe and critical conditions were significantly more common among children with comorbidities. More infants were hospitalized during the period of VOCs dominance, especially the delta variant, compared to the period of wild strain dominance, even though indications for hospitalization did not include asymptomatic patients during that period. The course of COVID-19 was mostly mild, characterized mainly by fever and respiratory symptoms. Comorbidities, particularly from the cardiovascular system and prematurity, were associated with a more severe course of the disease in infants.</abstract><cop>Switzerland</cop><pub>MDPI AG</pub><pmid>37048562</pmid><doi>10.3390/jcm12072479</doi><orcidid>https://orcid.org/0000-0003-1606-5100</orcidid><orcidid>https://orcid.org/0000-0002-5781-0886</orcidid><orcidid>https://orcid.org/0000-0002-7883-2427</orcidid><orcidid>https://orcid.org/0000-0003-0309-6987</orcidid><orcidid>https://orcid.org/0000-0003-0141-2560</orcidid><orcidid>https://orcid.org/0000-0003-1631-2159</orcidid><orcidid>https://orcid.org/0000-0002-6044-0425</orcidid><orcidid>https://orcid.org/0000-0003-2389-277X</orcidid><orcidid>https://orcid.org/0000-0003-2695-4649</orcidid><orcidid>https://orcid.org/0000-0001-7783-6904</orcidid><orcidid>https://orcid.org/0000-0003-3394-1635</orcidid><orcidid>https://orcid.org/0000-0001-5731-6346</orcidid><orcidid>https://orcid.org/0000-0001-5432-5394</orcidid><orcidid>https://orcid.org/0000-0002-8391-4793</orcidid><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 2077-0383 |
| ispartof | Journal of clinical medicine, 2023-03, Vol.12 (7), p.2479 |
| issn | 2077-0383 2077-0383 |
| language | eng |
| recordid | cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_10095202 |
| source | PubMed Central Open Access; MDPI - Multidisciplinary Digital Publishing Institute; Free E-Journal (出版社公開部分のみ）; PubMed Central |
| subjects | Age Asymptomatic Clinical medicine Coronaviruses COVID-19 Disease transmission Diseases Dyspnea Hospitalization Hospitals Infants (Newborn) Infections Laboratories Multisystem inflammatory syndrome in children Pandemics Pediatrics Pneumonia Severe acute respiratory syndrome coronavirus 2 |
| title | Clinical Course and Severity of COVID-19 in 940 Infants with and without Comorbidities Hospitalized in 2020 and 2021: The Results of the National Multicenter Database SARSTer-PED |
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