PINK1 Immunoexpression Predicts Survival in Patients Undergoing Hepatic Resection for Colorectal Liver Metastases

PTEN-induced kinase-1 (PINK1) is the initiator of the canonical mitophagy pathway. Our aim was to study the immunoexpression of PINK1 in surgical specimens from ninety patients with metastatic colorectal adenocarcinoma (CRC) to the liver (CRLM). Tissue arrays were produced, and immunohistochemical s...

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Veröffentlicht in:	International journal of molecular sciences 2023-03, Vol.24 (7), p.6506
Hauptverfasser:	Celis-Pinto, Juan Carlos, Fernández-Velasco, Adela Alonso, Corte-Torres, María Daniela, Santos-Juanes, Jorge, Blanco-Agudín, Noelia, Piña Batista, Kelvin Manuel, Merayo-Lloves, Jesús, Quirós, Luis M, Fernández-Vega, Iván
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenocarcinoma Cancer therapies Colorectal cancer Colorectal Neoplasms - genetics Colorectal Neoplasms - surgery Comparative analysis Development and progression Hepatectomy Humans Liver Liver Neoplasms - secondary Localization Medical prognosis Medical research Medicine, Experimental Metastases Metastasis Mutation Patient outcomes Patients Prognosis Protein Kinases - genetics PTEN protein PTEN-induced putative kinase Rectum Retrospective Studies Surgery Survival Survival analysis Tumors
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