Cytomegalovirus Glycoprotein B Genotype in Patients with Anterior Segment Infection
(1) The glycoprotein B (gB) on the viral envelope, encoded by the most widely characterised polymorphic gene, , is responsible for cytomegalovirus (CMV) entry into the host and could serve as a potential marker of pathogenicity. The aim of the present study is to investigate the distribution of the...
Gespeichert in:
| Veröffentlicht in: | International journal of molecular sciences 2023-03, Vol.24 (7), p.6304 |
|---|---|
| Hauptverfasser: | , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | |
|---|---|
| container_issue | 7 |
| container_start_page | 6304 |
| container_title | International journal of molecular sciences |
| container_volume | 24 |
| creator | Huang, Chu-Yen Cheng, Yu-Chun Hwang, Yih-Shiou Kang, Eugene Yu-Chuan Hsiao, Ching-Hsi |
| description | (1) The glycoprotein B (gB) on the viral envelope, encoded by the most widely characterised polymorphic gene,
, is responsible for cytomegalovirus (CMV) entry into the host and could serve as a potential marker of pathogenicity. The aim of the present study is to investigate the distribution of the CMV gB genotype in anterior segment infection in Taiwan and its correlation with clinical manifestations and outcomes. (2) Fifty-seven patients with CMV anterior segment infection were identified according to clinical features and positivity for CMV DNA in aqueous humour samples. CMV gB genotyping was performed through polymerase chain reaction assays. Patients' medical records were retrospectively reviewed. (3) Among the 57 aqueous humour samples tested for gB, 40 (70.28%) had multiple gB genotypes, and only 17 (29.82%) had a single gB genotype. Compared with single-genotype infection, multiple-genotype infection was correlated with higher CMV loads (
< 0.001) but not correlated with outcome. A higher proportion of patients with the gB3 genotype had received filtering surgery before antiviral treatment than those without the gB3 genotype (
= 0.046). (4) Multiple-genotype infection was highly prevalent in CMV anterior segment infection in Taiwan, and gB1 and gB3 were predominant. Multiple-genotype infection was correlated with higher CMV loads but not with specific clinical manifestations or prognostic outcomes. The gB3 genotype may be correlated with poor intraocular pressure control. |
| doi_str_mv | 10.3390/ijms24076304 |
| format | Article |
| fullrecord | <record><control><sourceid>gale_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_10094332</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><galeid>A751927317</galeid><sourcerecordid>A751927317</sourcerecordid><originalsourceid>FETCH-LOGICAL-c437t-a4cae5175804167a8cc508ca9e5dff7914623772c82fb89f30f555158f4af21c3</originalsourceid><addsrcrecordid>eNptkk1vVCEUhonR2A_duTY3ceOiU_m8wMpMJzo2aaJJdU0oc5gyuRdG4NbMv5dJa50awwI4POeF83IQekPwOWMafwibsVCOZc8wf4aOCad0hnEvnx-sj9BJKRuMKaNCv0RHTGIuqeyP0fViV9MIazuku5Cn0i2HnUvbnCqE2F10S4ip7rbQtd03WwPEWrpfod5281ghh5S7a1iPLdxdRg-uhhRfoRfeDgVeP8yn6MfnT98XX2ZXX5eXi_nVzHEm68xyZ0EQKRTmpJdWOSewclaDWHkvNeE9ZVJSp6i_Udoz7IUQRCjPrafEsVP08V53O92MsHLtEdkOZpvDaPPOJBvM05MYbs063RmCseaM0abw_kEhp58TlGrGUBwMg42QpmKoau5RTugeffcPuklTjq0-Q6XWveIaq79UMxRMiD61i91e1MylIJpKRmSjzv9DtbGCMbgUwYcWf5Jwdp_gciolg38skmCz7wJz2AUNf3tozCP859vZb6V2rLU</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2799684908</pqid></control><display><type>article</type><title>Cytomegalovirus Glycoprotein B Genotype in Patients with Anterior Segment Infection</title><source>MDPI - Multidisciplinary Digital Publishing Institute</source><source>MEDLINE</source><source>EZB-FREE-00999 freely available EZB journals</source><source>PubMed Central</source><creator>Huang, Chu-Yen ; Cheng, Yu-Chun ; Hwang, Yih-Shiou ; Kang, Eugene Yu-Chuan ; Hsiao, Ching-Hsi</creator><creatorcontrib>Huang, Chu-Yen ; Cheng, Yu-Chun ; Hwang, Yih-Shiou ; Kang, Eugene Yu-Chuan ; Hsiao, Ching-Hsi</creatorcontrib><description>(1) The glycoprotein B (gB) on the viral envelope, encoded by the most widely characterised polymorphic gene,
, is responsible for cytomegalovirus (CMV) entry into the host and could serve as a potential marker of pathogenicity. The aim of the present study is to investigate the distribution of the CMV gB genotype in anterior segment infection in Taiwan and its correlation with clinical manifestations and outcomes. (2) Fifty-seven patients with CMV anterior segment infection were identified according to clinical features and positivity for CMV DNA in aqueous humour samples. CMV gB genotyping was performed through polymerase chain reaction assays. Patients' medical records were retrospectively reviewed. (3) Among the 57 aqueous humour samples tested for gB, 40 (70.28%) had multiple gB genotypes, and only 17 (29.82%) had a single gB genotype. Compared with single-genotype infection, multiple-genotype infection was correlated with higher CMV loads (
< 0.001) but not correlated with outcome. A higher proportion of patients with the gB3 genotype had received filtering surgery before antiviral treatment than those without the gB3 genotype (
= 0.046). (4) Multiple-genotype infection was highly prevalent in CMV anterior segment infection in Taiwan, and gB1 and gB3 were predominant. Multiple-genotype infection was correlated with higher CMV loads but not with specific clinical manifestations or prognostic outcomes. The gB3 genotype may be correlated with poor intraocular pressure control.</description><identifier>ISSN: 1422-0067</identifier><identifier>ISSN: 1661-6596</identifier><identifier>EISSN: 1422-0067</identifier><identifier>DOI: 10.3390/ijms24076304</identifier><identifier>PMID: 37047276</identifier><language>eng</language><publisher>Switzerland: MDPI AG</publisher><subject>Antiviral agents ; Aqueous humour ; Care and treatment ; Communication ; Complications and side effects ; Cornea ; Correlation ; Cytomegalovirus ; Cytomegalovirus - genetics ; Cytomegalovirus Infections - genetics ; Development and progression ; DNA, Viral - analysis ; DNA, Viral - genetics ; Epstein-Barr virus ; Genes ; Genetic aspects ; Genotype ; Genotype & phenotype ; Genotypes ; Genotyping ; Glycoprotein B ; Glycoproteins ; Humans ; Immunocompetence ; Infection ; Infections ; Intraocular pressure ; Medical records ; Pathogenicity ; Patients ; Polymerase chain reaction ; Regression analysis ; Retrospective Studies ; Segments ; Surgery ; Transplants & implants ; Viral Envelope Proteins - genetics</subject><ispartof>International journal of molecular sciences, 2023-03, Vol.24 (7), p.6304</ispartof><rights>COPYRIGHT 2023 MDPI AG</rights><rights>2023 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>2023 by the authors. 2023</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c437t-a4cae5175804167a8cc508ca9e5dff7914623772c82fb89f30f555158f4af21c3</cites><orcidid>0000-0003-2744-3234 ; 0000-0001-6814-6530 ; 0000-0001-5745-9371</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC10094332/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC10094332/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,881,27901,27902,53766,53768</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/37047276$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Huang, Chu-Yen</creatorcontrib><creatorcontrib>Cheng, Yu-Chun</creatorcontrib><creatorcontrib>Hwang, Yih-Shiou</creatorcontrib><creatorcontrib>Kang, Eugene Yu-Chuan</creatorcontrib><creatorcontrib>Hsiao, Ching-Hsi</creatorcontrib><title>Cytomegalovirus Glycoprotein B Genotype in Patients with Anterior Segment Infection</title><title>International journal of molecular sciences</title><addtitle>Int J Mol Sci</addtitle><description>(1) The glycoprotein B (gB) on the viral envelope, encoded by the most widely characterised polymorphic gene,
, is responsible for cytomegalovirus (CMV) entry into the host and could serve as a potential marker of pathogenicity. The aim of the present study is to investigate the distribution of the CMV gB genotype in anterior segment infection in Taiwan and its correlation with clinical manifestations and outcomes. (2) Fifty-seven patients with CMV anterior segment infection were identified according to clinical features and positivity for CMV DNA in aqueous humour samples. CMV gB genotyping was performed through polymerase chain reaction assays. Patients' medical records were retrospectively reviewed. (3) Among the 57 aqueous humour samples tested for gB, 40 (70.28%) had multiple gB genotypes, and only 17 (29.82%) had a single gB genotype. Compared with single-genotype infection, multiple-genotype infection was correlated with higher CMV loads (
< 0.001) but not correlated with outcome. A higher proportion of patients with the gB3 genotype had received filtering surgery before antiviral treatment than those without the gB3 genotype (
= 0.046). (4) Multiple-genotype infection was highly prevalent in CMV anterior segment infection in Taiwan, and gB1 and gB3 were predominant. Multiple-genotype infection was correlated with higher CMV loads but not with specific clinical manifestations or prognostic outcomes. The gB3 genotype may be correlated with poor intraocular pressure control.</description><subject>Antiviral agents</subject><subject>Aqueous humour</subject><subject>Care and treatment</subject><subject>Communication</subject><subject>Complications and side effects</subject><subject>Cornea</subject><subject>Correlation</subject><subject>Cytomegalovirus</subject><subject>Cytomegalovirus - genetics</subject><subject>Cytomegalovirus Infections - genetics</subject><subject>Development and progression</subject><subject>DNA, Viral - analysis</subject><subject>DNA, Viral - genetics</subject><subject>Epstein-Barr virus</subject><subject>Genes</subject><subject>Genetic aspects</subject><subject>Genotype</subject><subject>Genotype & phenotype</subject><subject>Genotypes</subject><subject>Genotyping</subject><subject>Glycoprotein B</subject><subject>Glycoproteins</subject><subject>Humans</subject><subject>Immunocompetence</subject><subject>Infection</subject><subject>Infections</subject><subject>Intraocular pressure</subject><subject>Medical records</subject><subject>Pathogenicity</subject><subject>Patients</subject><subject>Polymerase chain reaction</subject><subject>Regression analysis</subject><subject>Retrospective Studies</subject><subject>Segments</subject><subject>Surgery</subject><subject>Transplants & implants</subject><subject>Viral Envelope Proteins - genetics</subject><issn>1422-0067</issn><issn>1661-6596</issn><issn>1422-0067</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2023</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>8G5</sourceid><sourceid>BENPR</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><recordid>eNptkk1vVCEUhonR2A_duTY3ceOiU_m8wMpMJzo2aaJJdU0oc5gyuRdG4NbMv5dJa50awwI4POeF83IQekPwOWMafwibsVCOZc8wf4aOCad0hnEvnx-sj9BJKRuMKaNCv0RHTGIuqeyP0fViV9MIazuku5Cn0i2HnUvbnCqE2F10S4ip7rbQtd03WwPEWrpfod5281ghh5S7a1iPLdxdRg-uhhRfoRfeDgVeP8yn6MfnT98XX2ZXX5eXi_nVzHEm68xyZ0EQKRTmpJdWOSewclaDWHkvNeE9ZVJSp6i_Udoz7IUQRCjPrafEsVP08V53O92MsHLtEdkOZpvDaPPOJBvM05MYbs063RmCseaM0abw_kEhp58TlGrGUBwMg42QpmKoau5RTugeffcPuklTjq0-Q6XWveIaq79UMxRMiD61i91e1MylIJpKRmSjzv9DtbGCMbgUwYcWf5Jwdp_gciolg38skmCz7wJz2AUNf3tozCP859vZb6V2rLU</recordid><startdate>20230327</startdate><enddate>20230327</enddate><creator>Huang, Chu-Yen</creator><creator>Cheng, Yu-Chun</creator><creator>Hwang, Yih-Shiou</creator><creator>Kang, Eugene Yu-Chuan</creator><creator>Hsiao, Ching-Hsi</creator><general>MDPI AG</general><general>MDPI</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>8G5</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>GUQSH</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>M2O</scope><scope>MBDVC</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>Q9U</scope><scope>7X8</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0003-2744-3234</orcidid><orcidid>https://orcid.org/0000-0001-6814-6530</orcidid><orcidid>https://orcid.org/0000-0001-5745-9371</orcidid></search><sort><creationdate>20230327</creationdate><title>Cytomegalovirus Glycoprotein B Genotype in Patients with Anterior Segment Infection</title><author>Huang, Chu-Yen ; Cheng, Yu-Chun ; Hwang, Yih-Shiou ; Kang, Eugene Yu-Chuan ; Hsiao, Ching-Hsi</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c437t-a4cae5175804167a8cc508ca9e5dff7914623772c82fb89f30f555158f4af21c3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2023</creationdate><topic>Antiviral agents</topic><topic>Aqueous humour</topic><topic>Care and treatment</topic><topic>Communication</topic><topic>Complications and side effects</topic><topic>Cornea</topic><topic>Correlation</topic><topic>Cytomegalovirus</topic><topic>Cytomegalovirus - genetics</topic><topic>Cytomegalovirus Infections - genetics</topic><topic>Development and progression</topic><topic>DNA, Viral - analysis</topic><topic>DNA, Viral - genetics</topic><topic>Epstein-Barr virus</topic><topic>Genes</topic><topic>Genetic aspects</topic><topic>Genotype</topic><topic>Genotype & phenotype</topic><topic>Genotypes</topic><topic>Genotyping</topic><topic>Glycoprotein B</topic><topic>Glycoproteins</topic><topic>Humans</topic><topic>Immunocompetence</topic><topic>Infection</topic><topic>Infections</topic><topic>Intraocular pressure</topic><topic>Medical records</topic><topic>Pathogenicity</topic><topic>Patients</topic><topic>Polymerase chain reaction</topic><topic>Regression analysis</topic><topic>Retrospective Studies</topic><topic>Segments</topic><topic>Surgery</topic><topic>Transplants & implants</topic><topic>Viral Envelope Proteins - genetics</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Huang, Chu-Yen</creatorcontrib><creatorcontrib>Cheng, Yu-Chun</creatorcontrib><creatorcontrib>Hwang, Yih-Shiou</creatorcontrib><creatorcontrib>Kang, Eugene Yu-Chuan</creatorcontrib><creatorcontrib>Hsiao, Ching-Hsi</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Research Library (Alumni Edition)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>Research Library Prep</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Research Library</collection><collection>Research Library (Corporate)</collection><collection>Publicly Available Content Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central Basic</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>International journal of molecular sciences</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Huang, Chu-Yen</au><au>Cheng, Yu-Chun</au><au>Hwang, Yih-Shiou</au><au>Kang, Eugene Yu-Chuan</au><au>Hsiao, Ching-Hsi</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Cytomegalovirus Glycoprotein B Genotype in Patients with Anterior Segment Infection</atitle><jtitle>International journal of molecular sciences</jtitle><addtitle>Int J Mol Sci</addtitle><date>2023-03-27</date><risdate>2023</risdate><volume>24</volume><issue>7</issue><spage>6304</spage><pages>6304-</pages><issn>1422-0067</issn><issn>1661-6596</issn><eissn>1422-0067</eissn><abstract>(1) The glycoprotein B (gB) on the viral envelope, encoded by the most widely characterised polymorphic gene,
, is responsible for cytomegalovirus (CMV) entry into the host and could serve as a potential marker of pathogenicity. The aim of the present study is to investigate the distribution of the CMV gB genotype in anterior segment infection in Taiwan and its correlation with clinical manifestations and outcomes. (2) Fifty-seven patients with CMV anterior segment infection were identified according to clinical features and positivity for CMV DNA in aqueous humour samples. CMV gB genotyping was performed through polymerase chain reaction assays. Patients' medical records were retrospectively reviewed. (3) Among the 57 aqueous humour samples tested for gB, 40 (70.28%) had multiple gB genotypes, and only 17 (29.82%) had a single gB genotype. Compared with single-genotype infection, multiple-genotype infection was correlated with higher CMV loads (
< 0.001) but not correlated with outcome. A higher proportion of patients with the gB3 genotype had received filtering surgery before antiviral treatment than those without the gB3 genotype (
= 0.046). (4) Multiple-genotype infection was highly prevalent in CMV anterior segment infection in Taiwan, and gB1 and gB3 were predominant. Multiple-genotype infection was correlated with higher CMV loads but not with specific clinical manifestations or prognostic outcomes. The gB3 genotype may be correlated with poor intraocular pressure control.</abstract><cop>Switzerland</cop><pub>MDPI AG</pub><pmid>37047276</pmid><doi>10.3390/ijms24076304</doi><orcidid>https://orcid.org/0000-0003-2744-3234</orcidid><orcidid>https://orcid.org/0000-0001-6814-6530</orcidid><orcidid>https://orcid.org/0000-0001-5745-9371</orcidid><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1422-0067 |
| ispartof | International journal of molecular sciences, 2023-03, Vol.24 (7), p.6304 |
| issn | 1422-0067 1661-6596 1422-0067 |
| language | eng |
| recordid | cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_10094332 |
| source | MDPI - Multidisciplinary Digital Publishing Institute; MEDLINE; EZB-FREE-00999 freely available EZB journals; PubMed Central |
| subjects | Antiviral agents Aqueous humour Care and treatment Communication Complications and side effects Cornea Correlation Cytomegalovirus Cytomegalovirus - genetics Cytomegalovirus Infections - genetics Development and progression DNA, Viral - analysis DNA, Viral - genetics Epstein-Barr virus Genes Genetic aspects Genotype Genotype & phenotype Genotypes Genotyping Glycoprotein B Glycoproteins Humans Immunocompetence Infection Infections Intraocular pressure Medical records Pathogenicity Patients Polymerase chain reaction Regression analysis Retrospective Studies Segments Surgery Transplants & implants Viral Envelope Proteins - genetics |
| title | Cytomegalovirus Glycoprotein B Genotype in Patients with Anterior Segment Infection |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-28T18%3A43%3A36IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-gale_pubme&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Cytomegalovirus%20Glycoprotein%20B%20Genotype%20in%20Patients%20with%20Anterior%20Segment%20Infection&rft.jtitle=International%20journal%20of%20molecular%20sciences&rft.au=Huang,%20Chu-Yen&rft.date=2023-03-27&rft.volume=24&rft.issue=7&rft.spage=6304&rft.pages=6304-&rft.issn=1422-0067&rft.eissn=1422-0067&rft_id=info:doi/10.3390/ijms24076304&rft_dat=%3Cgale_pubme%3EA751927317%3C/gale_pubme%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2799684908&rft_id=info:pmid/37047276&rft_galeid=A751927317&rfr_iscdi=true |