Cognitive Decline and Its Associated Factors in Patients with Major Depressive Disorder
Major Depressive Disorder (MDD) is a significant and common mental health problem occurring worldwide. Cognitive decline is frequently observed during acute and residual phases of MDD, contributing significantly to functional impairment. The aim of this study was to determine the clinical profile an...
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| Veröffentlicht in: | Healthcare (Basel) 2023-03, Vol.11 (7), p.950 |
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| description | Major Depressive Disorder (MDD) is a significant and common mental health problem occurring worldwide. Cognitive decline is frequently observed during acute and residual phases of MDD, contributing significantly to functional impairment. The aim of this study was to determine the clinical profile and correlates of cognitive decline amongst adult outpatients with MDD.
The survey was cross-sectional in design. A systematic random sampling method was used to recruit patients. Confirmation of MDD was achieved by using the Mini International Neuropsychiatric Interview (M.I.N.I 7.0). Cognitive decline was measured using the Montreal Cognitive Assessment (MoCA). Descriptive analysis was performed, followed by univariate and multiple logistic regression analyses.
Out of 245 patients, 32.7% (
= 80, 95% CI: 26.7, 38.6) had cognitive decline. Multiple logistic regression showed the existence of cognitive decline amongst MDD patients, which was significantly associated with those having secondary and lower levels of education (OR: 6.09; 95% CI: 2.82, 13.16;
< 0.001), five or more depressive episodes (OR: 8.93; 95% CI: 3.24, 24.67;
< 0.001), treatment non-compliance (OR: 3.48; 95% CI: 1.40, 6.59;
= 0.003), and medical comorbidity (OR: 2.74; 95% CI: 1.46, 5.18;
= 0.002).
Cognitive decline is a prevalent condition among outpatients with MDD. Clinicians need to be cognizant about measures of cognition and related risk factors. Timely control of both depression and medical comorbidities would be a reasonable approach to improve functional outcomes in MDD patients. |
| doi_str_mv | 10.3390/healthcare11070950 |
| format | Article |
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The survey was cross-sectional in design. A systematic random sampling method was used to recruit patients. Confirmation of MDD was achieved by using the Mini International Neuropsychiatric Interview (M.I.N.I 7.0). Cognitive decline was measured using the Montreal Cognitive Assessment (MoCA). Descriptive analysis was performed, followed by univariate and multiple logistic regression analyses.
Out of 245 patients, 32.7% (
= 80, 95% CI: 26.7, 38.6) had cognitive decline. Multiple logistic regression showed the existence of cognitive decline amongst MDD patients, which was significantly associated with those having secondary and lower levels of education (OR: 6.09; 95% CI: 2.82, 13.16;
< 0.001), five or more depressive episodes (OR: 8.93; 95% CI: 3.24, 24.67;
< 0.001), treatment non-compliance (OR: 3.48; 95% CI: 1.40, 6.59;
= 0.003), and medical comorbidity (OR: 2.74; 95% CI: 1.46, 5.18;
= 0.002).
Cognitive decline is a prevalent condition among outpatients with MDD. Clinicians need to be cognizant about measures of cognition and related risk factors. Timely control of both depression and medical comorbidities would be a reasonable approach to improve functional outcomes in MDD patients.</description><identifier>ISSN: 2227-9032</identifier><identifier>EISSN: 2227-9032</identifier><identifier>DOI: 10.3390/healthcare11070950</identifier><identifier>PMID: 37046877</identifier><language>eng</language><publisher>Switzerland: MDPI AG</publisher><subject>Bipolar disorder ; Clinical medicine ; Cognition & reasoning ; Cognition disorders ; Cognitive ability ; Complications and side effects ; Employment ; Ethnicity ; Executive function ; Family income ; Major depressive disorder ; Memory ; Mental depression ; Mental disorders ; Mental health ; Patients ; Remission (Medicine) ; Risk factors ; Sample size ; Schizophrenia ; Surveys ; Vitamin E</subject><ispartof>Healthcare (Basel), 2023-03, Vol.11 (7), p.950</ispartof><rights>COPYRIGHT 2023 MDPI AG</rights><rights>2023 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>2023 by the authors. 2023</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c498t-5e9f785b82efe1ee58885d81739448ef1765bbae63c52dc04c44a38aa28b81303</citedby><cites>FETCH-LOGICAL-c498t-5e9f785b82efe1ee58885d81739448ef1765bbae63c52dc04c44a38aa28b81303</cites><orcidid>0000-0001-8524-6576 ; 0000-0002-8979-7794</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC10094268/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC10094268/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,725,778,782,883,27911,27912,53778,53780</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/37046877$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Ab Latiff, Husni Zaim</creatorcontrib><creatorcontrib>Ariaratnam, Suthahar</creatorcontrib><creatorcontrib>Shuib, Norley</creatorcontrib><creatorcontrib>Isa, Mohamad Rodi</creatorcontrib><title>Cognitive Decline and Its Associated Factors in Patients with Major Depressive Disorder</title><title>Healthcare (Basel)</title><addtitle>Healthcare (Basel)</addtitle><description>Major Depressive Disorder (MDD) is a significant and common mental health problem occurring worldwide. Cognitive decline is frequently observed during acute and residual phases of MDD, contributing significantly to functional impairment. The aim of this study was to determine the clinical profile and correlates of cognitive decline amongst adult outpatients with MDD.
The survey was cross-sectional in design. A systematic random sampling method was used to recruit patients. Confirmation of MDD was achieved by using the Mini International Neuropsychiatric Interview (M.I.N.I 7.0). Cognitive decline was measured using the Montreal Cognitive Assessment (MoCA). Descriptive analysis was performed, followed by univariate and multiple logistic regression analyses.
Out of 245 patients, 32.7% (
= 80, 95% CI: 26.7, 38.6) had cognitive decline. Multiple logistic regression showed the existence of cognitive decline amongst MDD patients, which was significantly associated with those having secondary and lower levels of education (OR: 6.09; 95% CI: 2.82, 13.16;
< 0.001), five or more depressive episodes (OR: 8.93; 95% CI: 3.24, 24.67;
< 0.001), treatment non-compliance (OR: 3.48; 95% CI: 1.40, 6.59;
= 0.003), and medical comorbidity (OR: 2.74; 95% CI: 1.46, 5.18;
= 0.002).
Cognitive decline is a prevalent condition among outpatients with MDD. Clinicians need to be cognizant about measures of cognition and related risk factors. Timely control of both depression and medical comorbidities would be a reasonable approach to improve functional outcomes in MDD patients.</description><subject>Bipolar disorder</subject><subject>Clinical medicine</subject><subject>Cognition & reasoning</subject><subject>Cognition disorders</subject><subject>Cognitive ability</subject><subject>Complications and side effects</subject><subject>Employment</subject><subject>Ethnicity</subject><subject>Executive function</subject><subject>Family income</subject><subject>Major depressive disorder</subject><subject>Memory</subject><subject>Mental depression</subject><subject>Mental disorders</subject><subject>Mental health</subject><subject>Patients</subject><subject>Remission (Medicine)</subject><subject>Risk factors</subject><subject>Sample size</subject><subject>Schizophrenia</subject><subject>Surveys</subject><subject>Vitamin E</subject><issn>2227-9032</issn><issn>2227-9032</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2023</creationdate><recordtype>article</recordtype><sourceid>8G5</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><recordid>eNptUk1PGzEQtaqigoA_0ANaiUsvAX-tP04oSoEigdpDqx4tr3c2cbSxg-1Q8e8x5UOB1nOwNfPe88zoIfSZ4BPGND5dgB3LwtkEhGCJdYs_oD1KqZxozOjHrfcuOsx5ievRhCnWfkK7TGIulJR76PcszoMv_g6ar-BGH6CxoW-uSm6mOUfnbYG-ubCuxJQbH5oftngItfzHl0VzY5cxVeY6Qc5_RXyOqYd0gHYGO2Y4fL730a-L85-zb5Pr75dXs-n1xHGtyqQFPUjVdorCAASgVUq1vSKSac4VDESKtussCOZa2jvMHeeWKWup6hRhmO2jsyfd9aZbQe9qa8mOZp38yqZ7E603byvBL8w83hlS18GpUFXhy7NCircbyMWsfHYwjjZA3GRDFcaC1r5EhR6_gy7jJoU6n6FSa0EZl1uouR3B-DDE-rF7FDVTyYXmghFaUSf_QdXoYeVdDDD4mn9DoE8El2LOCYbXIQk2j5Yw_1qiko621_NKeTEAewCnTbMR</recordid><startdate>20230325</startdate><enddate>20230325</enddate><creator>Ab Latiff, Husni Zaim</creator><creator>Ariaratnam, Suthahar</creator><creator>Shuib, Norley</creator><creator>Isa, Mohamad Rodi</creator><general>MDPI AG</general><general>MDPI</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7RV</scope><scope>7XB</scope><scope>8C1</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>8G5</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>GUQSH</scope><scope>KB0</scope><scope>M2O</scope><scope>MBDVC</scope><scope>NAPCQ</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>Q9U</scope><scope>7X8</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0001-8524-6576</orcidid><orcidid>https://orcid.org/0000-0002-8979-7794</orcidid></search><sort><creationdate>20230325</creationdate><title>Cognitive Decline and Its Associated Factors in Patients with Major Depressive Disorder</title><author>Ab Latiff, Husni Zaim ; Ariaratnam, Suthahar ; Shuib, Norley ; Isa, Mohamad Rodi</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c498t-5e9f785b82efe1ee58885d81739448ef1765bbae63c52dc04c44a38aa28b81303</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2023</creationdate><topic>Bipolar disorder</topic><topic>Clinical medicine</topic><topic>Cognition & reasoning</topic><topic>Cognition disorders</topic><topic>Cognitive ability</topic><topic>Complications and side effects</topic><topic>Employment</topic><topic>Ethnicity</topic><topic>Executive function</topic><topic>Family income</topic><topic>Major depressive disorder</topic><topic>Memory</topic><topic>Mental depression</topic><topic>Mental disorders</topic><topic>Mental health</topic><topic>Patients</topic><topic>Remission (Medicine)</topic><topic>Risk factors</topic><topic>Sample size</topic><topic>Schizophrenia</topic><topic>Surveys</topic><topic>Vitamin E</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Ab Latiff, Husni Zaim</creatorcontrib><creatorcontrib>Ariaratnam, Suthahar</creatorcontrib><creatorcontrib>Shuib, Norley</creatorcontrib><creatorcontrib>Isa, Mohamad Rodi</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Nursing & Allied Health Database</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Public Health Database</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Research Library (Alumni Edition)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>Research Library Prep</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>Research Library</collection><collection>Research Library (Corporate)</collection><collection>Nursing & Allied Health Premium</collection><collection>Publicly Available Content Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central Basic</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Healthcare (Basel)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Ab Latiff, Husni Zaim</au><au>Ariaratnam, Suthahar</au><au>Shuib, Norley</au><au>Isa, Mohamad Rodi</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Cognitive Decline and Its Associated Factors in Patients with Major Depressive Disorder</atitle><jtitle>Healthcare (Basel)</jtitle><addtitle>Healthcare (Basel)</addtitle><date>2023-03-25</date><risdate>2023</risdate><volume>11</volume><issue>7</issue><spage>950</spage><pages>950-</pages><issn>2227-9032</issn><eissn>2227-9032</eissn><abstract>Major Depressive Disorder (MDD) is a significant and common mental health problem occurring worldwide. Cognitive decline is frequently observed during acute and residual phases of MDD, contributing significantly to functional impairment. The aim of this study was to determine the clinical profile and correlates of cognitive decline amongst adult outpatients with MDD.
The survey was cross-sectional in design. A systematic random sampling method was used to recruit patients. Confirmation of MDD was achieved by using the Mini International Neuropsychiatric Interview (M.I.N.I 7.0). Cognitive decline was measured using the Montreal Cognitive Assessment (MoCA). Descriptive analysis was performed, followed by univariate and multiple logistic regression analyses.
Out of 245 patients, 32.7% (
= 80, 95% CI: 26.7, 38.6) had cognitive decline. Multiple logistic regression showed the existence of cognitive decline amongst MDD patients, which was significantly associated with those having secondary and lower levels of education (OR: 6.09; 95% CI: 2.82, 13.16;
< 0.001), five or more depressive episodes (OR: 8.93; 95% CI: 3.24, 24.67;
< 0.001), treatment non-compliance (OR: 3.48; 95% CI: 1.40, 6.59;
= 0.003), and medical comorbidity (OR: 2.74; 95% CI: 1.46, 5.18;
= 0.002).
Cognitive decline is a prevalent condition among outpatients with MDD. Clinicians need to be cognizant about measures of cognition and related risk factors. Timely control of both depression and medical comorbidities would be a reasonable approach to improve functional outcomes in MDD patients.</abstract><cop>Switzerland</cop><pub>MDPI AG</pub><pmid>37046877</pmid><doi>10.3390/healthcare11070950</doi><orcidid>https://orcid.org/0000-0001-8524-6576</orcidid><orcidid>https://orcid.org/0000-0002-8979-7794</orcidid><oa>free_for_read</oa></addata></record> |
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| source | Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; PubMed Central Open Access; MDPI - Multidisciplinary Digital Publishing Institute; PubMed Central |
| subjects | Bipolar disorder Clinical medicine Cognition & reasoning Cognition disorders Cognitive ability Complications and side effects Employment Ethnicity Executive function Family income Major depressive disorder Memory Mental depression Mental disorders Mental health Patients Remission (Medicine) Risk factors Sample size Schizophrenia Surveys Vitamin E |
| title | Cognitive Decline and Its Associated Factors in Patients with Major Depressive Disorder |
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