Inhibition of Prolyl Oligopeptidase Restores Prohibitin 2 Levels in Psychosis Models: Relationship to Cognitive Deficits in Schizophrenia

Cognitive impairment represents one of the core features of schizophrenia. Prolyl Oligopeptidase (POP) inhibition is an emerging strategy for compensating cognitive deficits in hypoglutamatergic states such as schizophrenia, although little is known about how POP inhibitors exert their pharmacologic...

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Veröffentlicht in:	International journal of molecular sciences 2023-03, Vol.24 (7), p.6016
Hauptverfasser:	Vila, Èlia, Pinacho, Raquel, Prades, Roger, Tarragó, Teresa, Castro, Elena, Munarriz-Cuezva, Eva, Meana, J Javier, Eugui-Anta, Ania, Roldan, Mònica, Vera-Montecinos, América, Ramos, Belén
Format:	Artikel
Sprache:	eng
Schlagworte:	Analysis Animal cognition Animals Antagonists Antipsychotics Aspartate Astrocytes Brain research Cognition Cognitive Dysfunction - drug therapy Cognitive Dysfunction - etiology Confounding (Statistics) Cytoplasm Dizocilpine Dizocilpine Maleate - pharmacology Gene expression Glutamic acid receptors Hypotheses Immunocytochemistry Inhibition (psychology) Mental disorders Methyl aspartate Mitochondria N-Methyl-D-aspartic acid receptors Neurons Oligopeptidase Pathophysiology Phencyclidine Prefrontal cortex Prohibitin Prohibitins Prolyl oligopeptidase Prolyl Oligopeptidases - metabolism Proteins Psychosis Psychotic Disorders Psychotropic drugs Rats Receptors, N-Methyl-D-Aspartate - metabolism Schizophrenia Schizophrenia - drug therapy Schizophrenia - metabolism State finance
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