SB Digestor: a tailored driver gene identification tool for dissecting heterogeneous Sleeping Beauty transposon-induced tumors

Sleeping Beauty (SB) insertional mutagenesis has been widely used for genome-wide functional screening in mouse models of human cancers, however, intertumor heterogeneity can be a major obstacle in identifying common insertion sites (CISs). Although previous algorithms have been successful in defini...

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Veröffentlicht in:	International journal of biological sciences 2023-01, Vol.19 (6), p.1764-1777
Hauptverfasser:	Zhang, Aiping, Wang, Lijian, Lei, Josh Haipeng, Miao, Zhengqiang, Valecha, Monica Vishnu, Hu, Peng, Miao, Kai, Deng, Chu-Xia
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Disease Models, Animal DNA Transposable Elements - genetics Humans Mice Mutagenesis, Insertional - genetics Neoplasms - genetics Neoplasms - pathology Oncogenes Research Paper Transposases - genetics
Online-Zugang:	Volltext
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