The Chemerin Receptor CMKLR1 Requires Full‐Length Chemerin for High Affinity in Contrast to GPR1 as Demonstrated by a New Nanoluciferase‐Based Binding Assay

To study the binding mode of the adipokine chemerin as well as the short peptide agonist chemerin‐9 (C9) to its two receptors chemokine‐like receptor 1 (CMKLR1) and G protein‐coupled receptor 1 (GPR1), we generated 5‐carboxytetramethylrhodamine (TAMRA) modified variants of both ligands. In addition,...

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Veröffentlicht in:	ChemMedChem 2022-12, Vol.17 (23), p.e202200413-n/a
Hauptverfasser:	Czerniak, Anne Sophie, Kretschmer, Kevin, Weiß, Tina, Beck‐Sickinger, Annette G.
Format:	Artikel
Sprache:	eng
Schlagworte:	Affinity Assaying Binding chemerin Chemokines CMKLR1 GPR1 ligand binding Ligands peptides protein expression Receptors
Online-Zugang:	Volltext
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