Quantitative impact of pre‐analytical process on plasma uracil when testing for dihydropyrimidine dehydrogenase deficiency

Aims Determining dihydropyrimidine dehydrogenase (DPD) activity by measuring patient's uracil (U) plasma concentration is mandatory before fluoropyrimidine (FP) administration in France. In this study, we aimed to refine the pre‐analytical recommendations for determining U and dihydrouracil (UH...

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Veröffentlicht in:	British journal of clinical pharmacology 2023-02, Vol.89 (2), p.762-772
Hauptverfasser:	Maillard, Maud, Launay, Manon, Royer, Bernard, Guitton, Jérôme, Gautier‐Veyret, Elodie, Broutin, Sophie, Tron, Camille, Le Louedec, Félicien, Ciccolini, Joseph, Richard, Damien, Alarcan, Hugo, Haufroid, Vincent, Tafzi, Naïma, Schmitt, Antonin, Etienne‐Grimaldi, Marie‐Christine, Narjoz, Céline, Thomas, Fabienne
Format:	Artikel
Sprache:	eng
Schlagworte:	Biochemistry Biochemistry, Molecular Biology Cancer dihydropyrimidine dehydrogenase Dihydropyrimidine Dehydrogenase Deficiency - diagnosis dihydrouracil Dihydrouracil Dehydrogenase (NADP) - genetics Fluorouracil Humans intra‐individual variability Life Sciences Original Pharmaceutical sciences Pharmacology Phenotype Plasma pre‐analytical practices Uracil
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