Prognostic impact of MYD88 and CXCR4 mutations assessed by droplet digital polymerase chain reaction in IgM monoclonal gammopathy of undetermined significance and smouldering Waldenström macroglobulinaemia

Summary Waldenström macroglobulinaemia (WM) is characterized by recurrent somatic mutations in MYD88 and CXCR4 genes. However, limitations arise when analysing these mutations in IgM monoclonal gammopathy of undetermined significance (MGUS) or smouldering WM (SWM) given the lower tumour load. Here,...

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Veröffentlicht in:	British journal of haematology 2023-01, Vol.200 (2), p.187-196
Hauptverfasser:	Moreno, David F., López‐Guerra, Mónica, Paz, Sara, Oliver‐Caldés, Aina, Mena, Mari‐Pau, Correa, Juan G., Battram, Anthony M., Osuna, Miguel, Rivas‐Delgado, Alfredo, Rodríguez‐Lobato, Luis Gerardo, Cardús, Oriol, Tovar, Natalia, Cibeira, María Teresa, Jiménez‐Segura, Raquel, Bladé, Joan, Rosiñol, Laura, Colomer, Dolors, Fernández de Larrea, Carlos
Format:	Artikel
Sprache:	eng
Schlagworte:	Benign monoclonal gammopathy Bone marrow Cell-Free Nucleic Acids - genetics CXCR4 CXCR4 protein droplet digital PCR Haematological Malignancy–Clinical Hematology Humans IgM MGUS Immunoglobulin M Immunoglobulin M - genetics Lymphoma, B-Cell Metastases Monoclonal Gammopathy of Undetermined Significance - diagnosis Monoclonal Gammopathy of Undetermined Significance - genetics Mutation MYD88 MyD88 protein Myeloid Differentiation Factor 88 - genetics Original Paper Polymerase Chain Reaction Prognosis Receptors, CXCR4 - genetics Tumors Waldenstrom Macroglobulinemia - diagnosis Waldenstrom Macroglobulinemia - genetics Waldenström macroglobulinaemia
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