Auditory N100 amplitude deficits predict conversion to psychosis in the North American Prodrome Longitudinal Study (NAPLS-2) cohort

The auditory N100 is an event related potential (ERP) that is reduced in schizophrenia, but its status in individuals at clinical high risk for psychosis (CHR) and its ability to predict conversion to psychosis remains unclear. We examined whether N100 amplitudes are reduced in CHR subjects relative...

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Veröffentlicht in:Schizophrenia research 2022-10, Vol.248, p.89-97
Hauptverfasser: Duncan, Erica, Roach, Brian J., Massa, Nicholas, Hamilton, Holly K., Bachman, Peter M., Belger, Aysenil, Carrion, Ricardo E., Johannesen, Jason K., Light, Gregory A., Niznikiewicz, Margaret A., Addington, Jean M., Bearden, Carrie E., Cadenhead, Kristin S., Cannon, Tyrone D., Cornblatt, Barbara A., McGlashan, Thomas H., Perkins, Diana O., Tsuang, Ming, Walker, Elaine F., Woods, Scott W., Nasiri, Nima, Mathalon, Daniel H.
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container_end_page 97
container_issue
container_start_page 89
container_title Schizophrenia research
container_volume 248
creator Duncan, Erica
Roach, Brian J.
Massa, Nicholas
Hamilton, Holly K.
Bachman, Peter M.
Belger, Aysenil
Carrion, Ricardo E.
Johannesen, Jason K.
Light, Gregory A.
Niznikiewicz, Margaret A.
Addington, Jean M.
Bearden, Carrie E.
Cadenhead, Kristin S.
Cannon, Tyrone D.
Cornblatt, Barbara A.
McGlashan, Thomas H.
Perkins, Diana O.
Tsuang, Ming
Walker, Elaine F.
Woods, Scott W.
Nasiri, Nima
Mathalon, Daniel H.
description The auditory N100 is an event related potential (ERP) that is reduced in schizophrenia, but its status in individuals at clinical high risk for psychosis (CHR) and its ability to predict conversion to psychosis remains unclear. We examined whether N100 amplitudes are reduced in CHR subjects relative to healthy controls (HC), and this reduction predicts conversion to psychosis in CHR. Subjects included CHR individuals (n = 552) and demographically similar HC subjects (n = 236) from the North American Prodrome Longitudinal Study. Follow-up assessments identified CHR individuals who converted to psychosis (CHRC; n = 73) and those who did not (CHR-NC; n = 225) over 24 months. Electroencephalography data were collected during an auditory oddball task containing Standard, Novel, and Target stimuli. N100 peak amplitudes following each stimulus were measured at electrodes Cz and Fz. The CHR subjects had smaller N100 absolute amplitudes than HC subjects at Fz (F(1,786) = 4.00, p 0.046). A model comparing three groups (CHRC, CHR-NC, HC) was significant for Group at the Cz electrode (F(2,531) = 3.58, p = 0.029). Both Standard (p = 0.019) and Novel (p = 0.017) stimuli showed N100 absolute amplitude reductions in CHR-C relative to HC. A smaller N100 amplitude at Cz predicted conversion to psychosis in the CHR cohort (Standard: p = 0.009; Novel: p = 0.001) and predicted shorter time to conversion (Standard: p = 0.013; Novel: p = 0.001). N100 amplitudes are reduced in CHR individuals which precedes the onset of psychosis. N100 deficits in CHR individuals predict a greater likelihood of conversion to psychosis. Our results highlight N100's utility as a biomarker of psychosis risk.
doi_str_mv 10.1016/j.schres.2022.07.019
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source MEDLINE; ScienceDirect Journals (5 years ago - present)
subjects Auditory processing
Clinical high risk
Event-related potential (ERP)
Evoked Potentials
Humans
Longitudinal Studies
N100
North America
Prodromal Symptoms
Psychotic Disorders
Schizophrenia
title Auditory N100 amplitude deficits predict conversion to psychosis in the North American Prodrome Longitudinal Study (NAPLS-2) cohort
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