Auditory N100 amplitude deficits predict conversion to psychosis in the North American Prodrome Longitudinal Study (NAPLS-2) cohort
The auditory N100 is an event related potential (ERP) that is reduced in schizophrenia, but its status in individuals at clinical high risk for psychosis (CHR) and its ability to predict conversion to psychosis remains unclear. We examined whether N100 amplitudes are reduced in CHR subjects relative...
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Veröffentlicht in: | Schizophrenia research 2022-10, Vol.248, p.89-97 |
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creator | Duncan, Erica Roach, Brian J. Massa, Nicholas Hamilton, Holly K. Bachman, Peter M. Belger, Aysenil Carrion, Ricardo E. Johannesen, Jason K. Light, Gregory A. Niznikiewicz, Margaret A. Addington, Jean M. Bearden, Carrie E. Cadenhead, Kristin S. Cannon, Tyrone D. Cornblatt, Barbara A. McGlashan, Thomas H. Perkins, Diana O. Tsuang, Ming Walker, Elaine F. Woods, Scott W. Nasiri, Nima Mathalon, Daniel H. |
description | The auditory N100 is an event related potential (ERP) that is reduced in schizophrenia, but its status in individuals at clinical high risk for psychosis (CHR) and its ability to predict conversion to psychosis remains unclear. We examined whether N100 amplitudes are reduced in CHR subjects relative to healthy controls (HC), and this reduction predicts conversion to psychosis in CHR.
Subjects included CHR individuals (n = 552) and demographically similar HC subjects (n = 236) from the North American Prodrome Longitudinal Study. Follow-up assessments identified CHR individuals who converted to psychosis (CHRC; n = 73) and those who did not (CHR-NC; n = 225) over 24 months. Electroencephalography data were collected during an auditory oddball task containing Standard, Novel, and Target stimuli. N100 peak amplitudes following each stimulus were measured at electrodes Cz and Fz.
The CHR subjects had smaller N100 absolute amplitudes than HC subjects at Fz (F(1,786) = 4.00, p 0.046). A model comparing three groups (CHRC, CHR-NC, HC) was significant for Group at the Cz electrode (F(2,531) = 3.58, p = 0.029). Both Standard (p = 0.019) and Novel (p = 0.017) stimuli showed N100 absolute amplitude reductions in CHR-C relative to HC. A smaller N100 amplitude at Cz predicted conversion to psychosis in the CHR cohort (Standard: p = 0.009; Novel: p = 0.001) and predicted shorter time to conversion (Standard: p = 0.013; Novel: p = 0.001).
N100 amplitudes are reduced in CHR individuals which precedes the onset of psychosis. N100 deficits in CHR individuals predict a greater likelihood of conversion to psychosis. Our results highlight N100's utility as a biomarker of psychosis risk. |
doi_str_mv | 10.1016/j.schres.2022.07.019 |
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Subjects included CHR individuals (n = 552) and demographically similar HC subjects (n = 236) from the North American Prodrome Longitudinal Study. Follow-up assessments identified CHR individuals who converted to psychosis (CHRC; n = 73) and those who did not (CHR-NC; n = 225) over 24 months. Electroencephalography data were collected during an auditory oddball task containing Standard, Novel, and Target stimuli. N100 peak amplitudes following each stimulus were measured at electrodes Cz and Fz.
The CHR subjects had smaller N100 absolute amplitudes than HC subjects at Fz (F(1,786) = 4.00, p 0.046). A model comparing three groups (CHRC, CHR-NC, HC) was significant for Group at the Cz electrode (F(2,531) = 3.58, p = 0.029). Both Standard (p = 0.019) and Novel (p = 0.017) stimuli showed N100 absolute amplitude reductions in CHR-C relative to HC. A smaller N100 amplitude at Cz predicted conversion to psychosis in the CHR cohort (Standard: p = 0.009; Novel: p = 0.001) and predicted shorter time to conversion (Standard: p = 0.013; Novel: p = 0.001).
N100 amplitudes are reduced in CHR individuals which precedes the onset of psychosis. N100 deficits in CHR individuals predict a greater likelihood of conversion to psychosis. Our results highlight N100's utility as a biomarker of psychosis risk.</description><identifier>ISSN: 0920-9964</identifier><identifier>EISSN: 1573-2509</identifier><identifier>DOI: 10.1016/j.schres.2022.07.019</identifier><identifier>PMID: 35994912</identifier><language>eng</language><publisher>Netherlands: Elsevier B.V</publisher><subject>Auditory processing ; Clinical high risk ; Event-related potential (ERP) ; Evoked Potentials ; Humans ; Longitudinal Studies ; N100 ; North America ; Prodromal Symptoms ; Psychotic Disorders ; Schizophrenia</subject><ispartof>Schizophrenia research, 2022-10, Vol.248, p.89-97</ispartof><rights>2022</rights><rights>Published by Elsevier B.V.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c464t-eb6f4351ea727de5ae30aacad4d032286da21bbb2eaeac08f4f746ec66c8c26c3</citedby><cites>FETCH-LOGICAL-c464t-eb6f4351ea727de5ae30aacad4d032286da21bbb2eaeac08f4f746ec66c8c26c3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.schres.2022.07.019$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>230,315,781,785,886,3551,27929,27930,46000</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/35994912$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Duncan, Erica</creatorcontrib><creatorcontrib>Roach, Brian J.</creatorcontrib><creatorcontrib>Massa, Nicholas</creatorcontrib><creatorcontrib>Hamilton, Holly K.</creatorcontrib><creatorcontrib>Bachman, Peter M.</creatorcontrib><creatorcontrib>Belger, Aysenil</creatorcontrib><creatorcontrib>Carrion, Ricardo E.</creatorcontrib><creatorcontrib>Johannesen, Jason K.</creatorcontrib><creatorcontrib>Light, Gregory A.</creatorcontrib><creatorcontrib>Niznikiewicz, Margaret A.</creatorcontrib><creatorcontrib>Addington, Jean M.</creatorcontrib><creatorcontrib>Bearden, Carrie E.</creatorcontrib><creatorcontrib>Cadenhead, Kristin S.</creatorcontrib><creatorcontrib>Cannon, Tyrone D.</creatorcontrib><creatorcontrib>Cornblatt, Barbara A.</creatorcontrib><creatorcontrib>McGlashan, Thomas H.</creatorcontrib><creatorcontrib>Perkins, Diana O.</creatorcontrib><creatorcontrib>Tsuang, Ming</creatorcontrib><creatorcontrib>Walker, Elaine F.</creatorcontrib><creatorcontrib>Woods, Scott W.</creatorcontrib><creatorcontrib>Nasiri, Nima</creatorcontrib><creatorcontrib>Mathalon, Daniel H.</creatorcontrib><title>Auditory N100 amplitude deficits predict conversion to psychosis in the North American Prodrome Longitudinal Study (NAPLS-2) cohort</title><title>Schizophrenia research</title><addtitle>Schizophr Res</addtitle><description>The auditory N100 is an event related potential (ERP) that is reduced in schizophrenia, but its status in individuals at clinical high risk for psychosis (CHR) and its ability to predict conversion to psychosis remains unclear. We examined whether N100 amplitudes are reduced in CHR subjects relative to healthy controls (HC), and this reduction predicts conversion to psychosis in CHR.
Subjects included CHR individuals (n = 552) and demographically similar HC subjects (n = 236) from the North American Prodrome Longitudinal Study. Follow-up assessments identified CHR individuals who converted to psychosis (CHRC; n = 73) and those who did not (CHR-NC; n = 225) over 24 months. Electroencephalography data were collected during an auditory oddball task containing Standard, Novel, and Target stimuli. N100 peak amplitudes following each stimulus were measured at electrodes Cz and Fz.
The CHR subjects had smaller N100 absolute amplitudes than HC subjects at Fz (F(1,786) = 4.00, p 0.046). A model comparing three groups (CHRC, CHR-NC, HC) was significant for Group at the Cz electrode (F(2,531) = 3.58, p = 0.029). Both Standard (p = 0.019) and Novel (p = 0.017) stimuli showed N100 absolute amplitude reductions in CHR-C relative to HC. A smaller N100 amplitude at Cz predicted conversion to psychosis in the CHR cohort (Standard: p = 0.009; Novel: p = 0.001) and predicted shorter time to conversion (Standard: p = 0.013; Novel: p = 0.001).
N100 amplitudes are reduced in CHR individuals which precedes the onset of psychosis. N100 deficits in CHR individuals predict a greater likelihood of conversion to psychosis. Our results highlight N100's utility as a biomarker of psychosis risk.</description><subject>Auditory processing</subject><subject>Clinical high risk</subject><subject>Event-related potential (ERP)</subject><subject>Evoked Potentials</subject><subject>Humans</subject><subject>Longitudinal Studies</subject><subject>N100</subject><subject>North America</subject><subject>Prodromal Symptoms</subject><subject>Psychotic Disorders</subject><subject>Schizophrenia</subject><issn>0920-9964</issn><issn>1573-2509</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2022</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kc1u1DAUhS0EotPCGyDkZVkkXDs_nmxAowoK0mioVFhbjn3TeJTEwXZGmjUvjkdTKtiwsi2f892rcwh5wyBnwOr3-zzo3mPIOXCeg8iBNc_IilWiyHgFzXOygoZD1jR1eUEuQ9gDAKtAvCQXRdU0ZcP4ivzaLMZG5490xwCoGufBxsUgNdhZbWOgs0djdaTaTQf0wbqJRkfncNS9CzZQm9490p3zsaebEb3VaqJ33hnvRqRbNz2ciHZSA71PlyO93m3utvcZf5eYfbK9Ii86NQR8_XhekR-fP32_-ZJtv91-vdlsM13WZcywrbuyqBgqwYXBSmEBSmllSgMF5-vaKM7atuWoUGlYd2Unyhp1Xeu15rUursjHM3de2hGNxil6NcjZ21H5o3TKyn9_JtvLB3eQKZkUFi8S4fqR4N3PBUOUow0ah0FN6JYguYBKVMCZSNLyLNXeheCxe5rDQJ4KlHt5LlCeCpQgZCow2d7-veOT6U9jSfDhLMCU1MGiTxSLk04ledRRGmf_P-E3M7Ox-w</recordid><startdate>20221001</startdate><enddate>20221001</enddate><creator>Duncan, Erica</creator><creator>Roach, Brian J.</creator><creator>Massa, Nicholas</creator><creator>Hamilton, Holly K.</creator><creator>Bachman, Peter M.</creator><creator>Belger, Aysenil</creator><creator>Carrion, Ricardo E.</creator><creator>Johannesen, Jason K.</creator><creator>Light, Gregory A.</creator><creator>Niznikiewicz, Margaret A.</creator><creator>Addington, Jean M.</creator><creator>Bearden, Carrie E.</creator><creator>Cadenhead, Kristin S.</creator><creator>Cannon, Tyrone D.</creator><creator>Cornblatt, Barbara A.</creator><creator>McGlashan, Thomas H.</creator><creator>Perkins, Diana O.</creator><creator>Tsuang, Ming</creator><creator>Walker, Elaine F.</creator><creator>Woods, Scott W.</creator><creator>Nasiri, Nima</creator><creator>Mathalon, Daniel H.</creator><general>Elsevier B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20221001</creationdate><title>Auditory N100 amplitude deficits predict conversion to psychosis in the North American Prodrome Longitudinal Study (NAPLS-2) cohort</title><author>Duncan, Erica ; Roach, Brian J. ; Massa, Nicholas ; Hamilton, Holly K. ; Bachman, Peter M. ; Belger, Aysenil ; Carrion, Ricardo E. ; Johannesen, Jason K. ; Light, Gregory A. ; Niznikiewicz, Margaret A. ; Addington, Jean M. ; Bearden, Carrie E. ; Cadenhead, Kristin S. ; Cannon, Tyrone D. ; Cornblatt, Barbara A. ; McGlashan, Thomas H. ; Perkins, Diana O. ; Tsuang, Ming ; Walker, Elaine F. ; Woods, Scott W. ; Nasiri, Nima ; Mathalon, Daniel H.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c464t-eb6f4351ea727de5ae30aacad4d032286da21bbb2eaeac08f4f746ec66c8c26c3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2022</creationdate><topic>Auditory processing</topic><topic>Clinical high risk</topic><topic>Event-related potential (ERP)</topic><topic>Evoked Potentials</topic><topic>Humans</topic><topic>Longitudinal Studies</topic><topic>N100</topic><topic>North America</topic><topic>Prodromal Symptoms</topic><topic>Psychotic Disorders</topic><topic>Schizophrenia</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Duncan, Erica</creatorcontrib><creatorcontrib>Roach, Brian J.</creatorcontrib><creatorcontrib>Massa, Nicholas</creatorcontrib><creatorcontrib>Hamilton, Holly K.</creatorcontrib><creatorcontrib>Bachman, Peter M.</creatorcontrib><creatorcontrib>Belger, Aysenil</creatorcontrib><creatorcontrib>Carrion, Ricardo E.</creatorcontrib><creatorcontrib>Johannesen, Jason K.</creatorcontrib><creatorcontrib>Light, Gregory A.</creatorcontrib><creatorcontrib>Niznikiewicz, Margaret A.</creatorcontrib><creatorcontrib>Addington, Jean M.</creatorcontrib><creatorcontrib>Bearden, Carrie E.</creatorcontrib><creatorcontrib>Cadenhead, Kristin S.</creatorcontrib><creatorcontrib>Cannon, Tyrone D.</creatorcontrib><creatorcontrib>Cornblatt, Barbara A.</creatorcontrib><creatorcontrib>McGlashan, Thomas H.</creatorcontrib><creatorcontrib>Perkins, Diana O.</creatorcontrib><creatorcontrib>Tsuang, Ming</creatorcontrib><creatorcontrib>Walker, Elaine F.</creatorcontrib><creatorcontrib>Woods, Scott W.</creatorcontrib><creatorcontrib>Nasiri, Nima</creatorcontrib><creatorcontrib>Mathalon, Daniel H.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Schizophrenia research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Duncan, Erica</au><au>Roach, Brian J.</au><au>Massa, Nicholas</au><au>Hamilton, Holly K.</au><au>Bachman, Peter M.</au><au>Belger, Aysenil</au><au>Carrion, Ricardo E.</au><au>Johannesen, Jason K.</au><au>Light, Gregory A.</au><au>Niznikiewicz, Margaret A.</au><au>Addington, Jean M.</au><au>Bearden, Carrie E.</au><au>Cadenhead, Kristin S.</au><au>Cannon, Tyrone D.</au><au>Cornblatt, Barbara A.</au><au>McGlashan, Thomas H.</au><au>Perkins, Diana O.</au><au>Tsuang, Ming</au><au>Walker, Elaine F.</au><au>Woods, Scott W.</au><au>Nasiri, Nima</au><au>Mathalon, Daniel H.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Auditory N100 amplitude deficits predict conversion to psychosis in the North American Prodrome Longitudinal Study (NAPLS-2) cohort</atitle><jtitle>Schizophrenia research</jtitle><addtitle>Schizophr Res</addtitle><date>2022-10-01</date><risdate>2022</risdate><volume>248</volume><spage>89</spage><epage>97</epage><pages>89-97</pages><issn>0920-9964</issn><eissn>1573-2509</eissn><abstract>The auditory N100 is an event related potential (ERP) that is reduced in schizophrenia, but its status in individuals at clinical high risk for psychosis (CHR) and its ability to predict conversion to psychosis remains unclear. We examined whether N100 amplitudes are reduced in CHR subjects relative to healthy controls (HC), and this reduction predicts conversion to psychosis in CHR.
Subjects included CHR individuals (n = 552) and demographically similar HC subjects (n = 236) from the North American Prodrome Longitudinal Study. Follow-up assessments identified CHR individuals who converted to psychosis (CHRC; n = 73) and those who did not (CHR-NC; n = 225) over 24 months. Electroencephalography data were collected during an auditory oddball task containing Standard, Novel, and Target stimuli. N100 peak amplitudes following each stimulus were measured at electrodes Cz and Fz.
The CHR subjects had smaller N100 absolute amplitudes than HC subjects at Fz (F(1,786) = 4.00, p 0.046). A model comparing three groups (CHRC, CHR-NC, HC) was significant for Group at the Cz electrode (F(2,531) = 3.58, p = 0.029). Both Standard (p = 0.019) and Novel (p = 0.017) stimuli showed N100 absolute amplitude reductions in CHR-C relative to HC. A smaller N100 amplitude at Cz predicted conversion to psychosis in the CHR cohort (Standard: p = 0.009; Novel: p = 0.001) and predicted shorter time to conversion (Standard: p = 0.013; Novel: p = 0.001).
N100 amplitudes are reduced in CHR individuals which precedes the onset of psychosis. N100 deficits in CHR individuals predict a greater likelihood of conversion to psychosis. Our results highlight N100's utility as a biomarker of psychosis risk.</abstract><cop>Netherlands</cop><pub>Elsevier B.V</pub><pmid>35994912</pmid><doi>10.1016/j.schres.2022.07.019</doi><tpages>9</tpages><oa>free_for_read</oa></addata></record> |
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subjects | Auditory processing Clinical high risk Event-related potential (ERP) Evoked Potentials Humans Longitudinal Studies N100 North America Prodromal Symptoms Psychotic Disorders Schizophrenia |
title | Auditory N100 amplitude deficits predict conversion to psychosis in the North American Prodrome Longitudinal Study (NAPLS-2) cohort |
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