CircRPPH1 accelerates the proliferation and migration of bladder cancer via enhancing the STAT3 signaling pathway
Bladder cancer (BCa) is a common malignant disease with high recurrence and variable prognosis. Circular RNAs (circRNAs) are implicated in the development of multiple diseases. However, the biological activities of circRNAs in BCa remain largely elusive. In the present study, it was found that circR...
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| Veröffentlicht in: | Oncology reports 2023-05, Vol.49 (5), p.1, Article 103 |
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| creator | Liu, Xiao Tong, Yonghua Huang, Qiu He, Yu Shang, Haojie Chen, Zhiqiang Tang, Kun |
| description | Bladder cancer (BCa) is a common malignant disease with high recurrence and variable prognosis. Circular RNAs (circRNAs) are implicated in the development of multiple diseases. However, the biological activities of circRNAs in BCa remain largely elusive. In the present study, it was found that circRPPH1 was upregulated in BCa cell lines compared with normal urothelial cells. CircRPPH1 downregulation could inhibit the proliferation, migration and invasion of BCa cells
and
. Mechanistically, it was demonstrated that circRPPH1 can act as a sponge of miR‑296‑5P to upregulate STAT3, and interact with FUS to promote phosphorylated (p)‑STAT3 nuclear transport. Overall, circRPPH1 could promote BCa progression through sponging miR‑296‑5p to upregulate the expression of STAT3 and interacting with FUS to promote p‑STAT3 nuclear transport. CircRPPH1 was first identified to play a tumorigenic role in BCa, which could be an underlying therapeutic target. |
| doi_str_mv | 10.3892/or.2023.8540 |
| format | Article |
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and
. Mechanistically, it was demonstrated that circRPPH1 can act as a sponge of miR‑296‑5P to upregulate STAT3, and interact with FUS to promote phosphorylated (p)‑STAT3 nuclear transport. Overall, circRPPH1 could promote BCa progression through sponging miR‑296‑5p to upregulate the expression of STAT3 and interacting with FUS to promote p‑STAT3 nuclear transport. CircRPPH1 was first identified to play a tumorigenic role in BCa, which could be an underlying therapeutic target.</description><identifier>ISSN: 1021-335X</identifier><identifier>EISSN: 1791-2431</identifier><identifier>DOI: 10.3892/or.2023.8540</identifier><identifier>PMID: 36999615</identifier><language>eng</language><publisher>Greece: Spandidos Publications</publisher><subject>Bioinformatics ; Biotechnology ; Bladder cancer ; Cancer therapies ; Cell Line, Tumor ; Cell Movement - genetics ; Cell Proliferation - genetics ; Cloning ; Comparative analysis ; Development and progression ; Diseases ; Gene Expression Regulation, Neoplastic ; Health aspects ; Humans ; Kinases ; Manufacturers ; Manufacturing ; Metastasis ; MicroRNAs - genetics ; Plasmids ; Prognosis ; Proteins ; Relapse ; RNA ; RNA, Circular - genetics ; Scientific equipment and supplies industry ; Signal Transduction - genetics ; Software ; STAT3 Transcription Factor - genetics ; STAT3 Transcription Factor - metabolism ; Urinary Bladder Neoplasms - pathology</subject><ispartof>Oncology reports, 2023-05, Vol.49 (5), p.1, Article 103</ispartof><rights>COPYRIGHT 2023 Spandidos Publications</rights><rights>Copyright Spandidos Publications UK Ltd. 2023</rights><rights>Copyright: © Liu et al. 2023</rights><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c511t-9302d7ac20c5eb0d01697aa368696a0b78a4b9e5d95d4eefeef7f6a02bc9c3d03</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>230,314,780,784,885,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/36999615$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Liu, Xiao</creatorcontrib><creatorcontrib>Tong, Yonghua</creatorcontrib><creatorcontrib>Huang, Qiu</creatorcontrib><creatorcontrib>He, Yu</creatorcontrib><creatorcontrib>Shang, Haojie</creatorcontrib><creatorcontrib>Chen, Zhiqiang</creatorcontrib><creatorcontrib>Tang, Kun</creatorcontrib><title>CircRPPH1 accelerates the proliferation and migration of bladder cancer via enhancing the STAT3 signaling pathway</title><title>Oncology reports</title><addtitle>Oncol Rep</addtitle><description>Bladder cancer (BCa) is a common malignant disease with high recurrence and variable prognosis. Circular RNAs (circRNAs) are implicated in the development of multiple diseases. However, the biological activities of circRNAs in BCa remain largely elusive. In the present study, it was found that circRPPH1 was upregulated in BCa cell lines compared with normal urothelial cells. CircRPPH1 downregulation could inhibit the proliferation, migration and invasion of BCa cells
and
. Mechanistically, it was demonstrated that circRPPH1 can act as a sponge of miR‑296‑5P to upregulate STAT3, and interact with FUS to promote phosphorylated (p)‑STAT3 nuclear transport. Overall, circRPPH1 could promote BCa progression through sponging miR‑296‑5p to upregulate the expression of STAT3 and interacting with FUS to promote p‑STAT3 nuclear transport. CircRPPH1 was first identified to play a tumorigenic role in BCa, which could be an underlying therapeutic target.</description><subject>Bioinformatics</subject><subject>Biotechnology</subject><subject>Bladder cancer</subject><subject>Cancer therapies</subject><subject>Cell Line, Tumor</subject><subject>Cell Movement - genetics</subject><subject>Cell Proliferation - genetics</subject><subject>Cloning</subject><subject>Comparative analysis</subject><subject>Development and progression</subject><subject>Diseases</subject><subject>Gene Expression Regulation, Neoplastic</subject><subject>Health aspects</subject><subject>Humans</subject><subject>Kinases</subject><subject>Manufacturers</subject><subject>Manufacturing</subject><subject>Metastasis</subject><subject>MicroRNAs - genetics</subject><subject>Plasmids</subject><subject>Prognosis</subject><subject>Proteins</subject><subject>Relapse</subject><subject>RNA</subject><subject>RNA, Circular - genetics</subject><subject>Scientific equipment and supplies industry</subject><subject>Signal Transduction - genetics</subject><subject>Software</subject><subject>STAT3 Transcription Factor - genetics</subject><subject>STAT3 Transcription Factor - metabolism</subject><subject>Urinary Bladder Neoplasms - pathology</subject><issn>1021-335X</issn><issn>1791-2431</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2023</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><recordid>eNptkt-L1DAQx4so3g9981kKgvhg1_xo2ubpWBb1hAMPXcG3ME3SNkea7CXtyf33l3rreSuSwGRmPvMNmUyWvcJoRRtOPviwIojQVcNK9CQ7xjXHBSkpfprOiOCCUvbzKDuJ8QohUqOKP8-OaMU5rzA7zq43Jshvl5fnOAcptdUBJh3zadD5LnhruiVgvMvBqXw0_d7zXd5aUEqHXIKTydwYyLUbkmNc_7v--3a9pXk0vQO7xHYwDb_g9kX2rAMb9cu9Pc1-fPq43ZwXF18_f9msLwrJMJ4KThFRNUiCJNMtUghXvAagVVPxClBbN1C2XDPFmSq17tKuu5QgreSSKkRPs7N73d3cjlpJ7aYAVuyCGSHcCg9GHGacGUTvbwRGiGNU86Twbq8Q_PWs4yRGE1OPLDjt5yhIYjgnjJKEvvkHvfJzSA9PVIOasuS4av5SPVgtjOt8ulguomJdl5wxRNFCrf5DpaX0aKR3ujMpflDw9lHBoMFOQ_R2Xn4qHoLv70EZfIxBdw_dwEgswyR8EMswiWWYEv76cQcf4D_TQ-8Aqm7EPA</recordid><startdate>20230501</startdate><enddate>20230501</enddate><creator>Liu, Xiao</creator><creator>Tong, Yonghua</creator><creator>Huang, Qiu</creator><creator>He, Yu</creator><creator>Shang, Haojie</creator><creator>Chen, Zhiqiang</creator><creator>Tang, Kun</creator><general>Spandidos Publications</general><general>Spandidos Publications UK Ltd</general><general>D.A. Spandidos</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AN0</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20230501</creationdate><title>CircRPPH1 accelerates the proliferation and migration of bladder cancer via enhancing the STAT3 signaling pathway</title><author>Liu, Xiao ; Tong, Yonghua ; Huang, Qiu ; He, Yu ; Shang, Haojie ; Chen, Zhiqiang ; Tang, Kun</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c511t-9302d7ac20c5eb0d01697aa368696a0b78a4b9e5d95d4eefeef7f6a02bc9c3d03</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2023</creationdate><topic>Bioinformatics</topic><topic>Biotechnology</topic><topic>Bladder cancer</topic><topic>Cancer therapies</topic><topic>Cell Line, Tumor</topic><topic>Cell Movement - genetics</topic><topic>Cell Proliferation - genetics</topic><topic>Cloning</topic><topic>Comparative analysis</topic><topic>Development and progression</topic><topic>Diseases</topic><topic>Gene Expression Regulation, Neoplastic</topic><topic>Health aspects</topic><topic>Humans</topic><topic>Kinases</topic><topic>Manufacturers</topic><topic>Manufacturing</topic><topic>Metastasis</topic><topic>MicroRNAs - genetics</topic><topic>Plasmids</topic><topic>Prognosis</topic><topic>Proteins</topic><topic>Relapse</topic><topic>RNA</topic><topic>RNA, Circular - genetics</topic><topic>Scientific equipment and supplies industry</topic><topic>Signal Transduction - genetics</topic><topic>Software</topic><topic>STAT3 Transcription Factor - genetics</topic><topic>STAT3 Transcription Factor - metabolism</topic><topic>Urinary Bladder Neoplasms - pathology</topic><toplevel>online_resources</toplevel><creatorcontrib>Liu, Xiao</creatorcontrib><creatorcontrib>Tong, Yonghua</creatorcontrib><creatorcontrib>Huang, Qiu</creatorcontrib><creatorcontrib>He, Yu</creatorcontrib><creatorcontrib>Shang, Haojie</creatorcontrib><creatorcontrib>Chen, Zhiqiang</creatorcontrib><creatorcontrib>Tang, Kun</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>British Nursing Database</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Oncology reports</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Liu, Xiao</au><au>Tong, Yonghua</au><au>Huang, Qiu</au><au>He, Yu</au><au>Shang, Haojie</au><au>Chen, Zhiqiang</au><au>Tang, Kun</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>CircRPPH1 accelerates the proliferation and migration of bladder cancer via enhancing the STAT3 signaling pathway</atitle><jtitle>Oncology reports</jtitle><addtitle>Oncol Rep</addtitle><date>2023-05-01</date><risdate>2023</risdate><volume>49</volume><issue>5</issue><spage>1</spage><pages>1-</pages><artnum>103</artnum><issn>1021-335X</issn><eissn>1791-2431</eissn><abstract>Bladder cancer (BCa) is a common malignant disease with high recurrence and variable prognosis. Circular RNAs (circRNAs) are implicated in the development of multiple diseases. However, the biological activities of circRNAs in BCa remain largely elusive. In the present study, it was found that circRPPH1 was upregulated in BCa cell lines compared with normal urothelial cells. CircRPPH1 downregulation could inhibit the proliferation, migration and invasion of BCa cells
and
. Mechanistically, it was demonstrated that circRPPH1 can act as a sponge of miR‑296‑5P to upregulate STAT3, and interact with FUS to promote phosphorylated (p)‑STAT3 nuclear transport. Overall, circRPPH1 could promote BCa progression through sponging miR‑296‑5p to upregulate the expression of STAT3 and interacting with FUS to promote p‑STAT3 nuclear transport. CircRPPH1 was first identified to play a tumorigenic role in BCa, which could be an underlying therapeutic target.</abstract><cop>Greece</cop><pub>Spandidos Publications</pub><pmid>36999615</pmid><doi>10.3892/or.2023.8540</doi><oa>free_for_read</oa></addata></record> |
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| ispartof | Oncology reports, 2023-05, Vol.49 (5), p.1, Article 103 |
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| source | MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; Alma/SFX Local Collection |
| subjects | Bioinformatics Biotechnology Bladder cancer Cancer therapies Cell Line, Tumor Cell Movement - genetics Cell Proliferation - genetics Cloning Comparative analysis Development and progression Diseases Gene Expression Regulation, Neoplastic Health aspects Humans Kinases Manufacturers Manufacturing Metastasis MicroRNAs - genetics Plasmids Prognosis Proteins Relapse RNA RNA, Circular - genetics Scientific equipment and supplies industry Signal Transduction - genetics Software STAT3 Transcription Factor - genetics STAT3 Transcription Factor - metabolism Urinary Bladder Neoplasms - pathology |
| title | CircRPPH1 accelerates the proliferation and migration of bladder cancer via enhancing the STAT3 signaling pathway |
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