Objective and Subjective Sleep Patterns in Adults With Maturity-Onset Diabetes of the Young (MODY)
To examine sleep patterns in adults with maturity-onset diabetes of the young (MODY). Adults with glucokinase (GCK)-MODY and transcription factor (TF)-related MODY (HNF1A, HNF1B, HNF4A) were recruited (n = 24; age 46.0 years, 79% women, BMI 24.7 kg/m2) from The University of Chicago's Monogenic...
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| Veröffentlicht in: | Diabetes care 2023-03, Vol.46 (3), p.608-612 |
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| creator | Arosemena, Marilyn Salguero, Maria V Naylor, Rochelle N Wroblewski, Kristen Tasali, Esra Philipson, Louis H |
| description | To examine sleep patterns in adults with maturity-onset diabetes of the young (MODY).
Adults with glucokinase (GCK)-MODY and transcription factor (TF)-related MODY (HNF1A, HNF1B, HNF4A) were recruited (n = 24; age 46.0 years, 79% women, BMI 24.7 kg/m2) from The University of Chicago's Monogenic Diabetes Registry. Sleep patterns were assessed by 2-week wrist actigraphy (total 315 nights), one night of a home sleep apnea test, and validated surveys.
Overall, compared with established criteria, 29% of participants had sleep latency ≥15 min, 38% had sleep efficiency ≤85%, 46% had wake after sleep onset >40 min, all indicating poor objective sleep quality. Among all participants, 54% had a sleep duration below the recommended minimum of 7 h, 88% reported poor sleep quality, 58% had obstructive sleep apnea, and 71% reported insomnia. Compared with GCK-MODY, participants with TF-related MODY had poorer objective sleep quality and increased night-to-night variability in sleep patterns.
Sleep disturbances appear to be common in adults with MODY despite absent traditional risk factors for sleep disorders. Future research investigating the sleep-diabetes relationship is warranted in this population. |
| doi_str_mv | 10.2337/dc22-1343 |
| format | Article |
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Adults with glucokinase (GCK)-MODY and transcription factor (TF)-related MODY (HNF1A, HNF1B, HNF4A) were recruited (n = 24; age 46.0 years, 79% women, BMI 24.7 kg/m2) from The University of Chicago's Monogenic Diabetes Registry. Sleep patterns were assessed by 2-week wrist actigraphy (total 315 nights), one night of a home sleep apnea test, and validated surveys.
Overall, compared with established criteria, 29% of participants had sleep latency ≥15 min, 38% had sleep efficiency ≤85%, 46% had wake after sleep onset >40 min, all indicating poor objective sleep quality. Among all participants, 54% had a sleep duration below the recommended minimum of 7 h, 88% reported poor sleep quality, 58% had obstructive sleep apnea, and 71% reported insomnia. Compared with GCK-MODY, participants with TF-related MODY had poorer objective sleep quality and increased night-to-night variability in sleep patterns.
Sleep disturbances appear to be common in adults with MODY despite absent traditional risk factors for sleep disorders. Future research investigating the sleep-diabetes relationship is warranted in this population.</description><identifier>ISSN: 0149-5992</identifier><identifier>EISSN: 1935-5548</identifier><identifier>DOI: 10.2337/dc22-1343</identifier><identifier>PMID: 36637968</identifier><language>eng</language><publisher>United States: American Diabetes Association</publisher><subject>Adults ; Apnea ; Brief Report ; Diabetes ; Diabetes mellitus ; Diabetes Mellitus, Type 2 - complications ; Diabetes Mellitus, Type 2 - epidemiology ; Female ; Glucokinase ; Glucokinase - genetics ; Health risks ; Hepatocyte Nuclear Factor 1-alpha - genetics ; Hepatocyte nuclear factor 4 ; Humans ; Insomnia ; Male ; Middle Aged ; Mutation ; Night ; Research design ; Risk Factors ; Sleep ; Sleep and wakefulness ; Sleep apnea ; Sleep disorders ; Sleep Disorders, Intrinsic - etiology ; Wrist</subject><ispartof>Diabetes care, 2023-03, Vol.46 (3), p.608-612</ispartof><rights>2023 by the American Diabetes Association.</rights><rights>Copyright American Diabetes Association Mar 2023</rights><rights>2023 by the American Diabetes Association 2023</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c364t-1957ac665604cad090c9812cf418f3a5156c6e2ce1712028e47fb5d33cafec2d3</cites><orcidid>0000-0002-8185-4707</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>230,314,776,780,881,27901,27902</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/36637968$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Arosemena, Marilyn</creatorcontrib><creatorcontrib>Salguero, Maria V</creatorcontrib><creatorcontrib>Naylor, Rochelle N</creatorcontrib><creatorcontrib>Wroblewski, Kristen</creatorcontrib><creatorcontrib>Tasali, Esra</creatorcontrib><creatorcontrib>Philipson, Louis H</creatorcontrib><title>Objective and Subjective Sleep Patterns in Adults With Maturity-Onset Diabetes of the Young (MODY)</title><title>Diabetes care</title><addtitle>Diabetes Care</addtitle><description>To examine sleep patterns in adults with maturity-onset diabetes of the young (MODY).
Adults with glucokinase (GCK)-MODY and transcription factor (TF)-related MODY (HNF1A, HNF1B, HNF4A) were recruited (n = 24; age 46.0 years, 79% women, BMI 24.7 kg/m2) from The University of Chicago's Monogenic Diabetes Registry. Sleep patterns were assessed by 2-week wrist actigraphy (total 315 nights), one night of a home sleep apnea test, and validated surveys.
Overall, compared with established criteria, 29% of participants had sleep latency ≥15 min, 38% had sleep efficiency ≤85%, 46% had wake after sleep onset >40 min, all indicating poor objective sleep quality. Among all participants, 54% had a sleep duration below the recommended minimum of 7 h, 88% reported poor sleep quality, 58% had obstructive sleep apnea, and 71% reported insomnia. Compared with GCK-MODY, participants with TF-related MODY had poorer objective sleep quality and increased night-to-night variability in sleep patterns.
Sleep disturbances appear to be common in adults with MODY despite absent traditional risk factors for sleep disorders. Future research investigating the sleep-diabetes relationship is warranted in this population.</description><subject>Adults</subject><subject>Apnea</subject><subject>Brief Report</subject><subject>Diabetes</subject><subject>Diabetes mellitus</subject><subject>Diabetes Mellitus, Type 2 - complications</subject><subject>Diabetes Mellitus, Type 2 - epidemiology</subject><subject>Female</subject><subject>Glucokinase</subject><subject>Glucokinase - genetics</subject><subject>Health risks</subject><subject>Hepatocyte Nuclear Factor 1-alpha - genetics</subject><subject>Hepatocyte nuclear factor 4</subject><subject>Humans</subject><subject>Insomnia</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Mutation</subject><subject>Night</subject><subject>Research design</subject><subject>Risk Factors</subject><subject>Sleep</subject><subject>Sleep and wakefulness</subject><subject>Sleep apnea</subject><subject>Sleep disorders</subject><subject>Sleep Disorders, Intrinsic - etiology</subject><subject>Wrist</subject><issn>0149-5992</issn><issn>1935-5548</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2023</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpdkU1rGzEQhkVpaBynh_6BIuglOWyj79WeikmaNuDgQBKCT0KrnY1l1lpX0gby77smqUlzGoZ5eGeGB6EvlHxnnJdnjWOsoFzwD2hCKy4LKYX-iCaEiqqQVcUO0VFKa0KIEFp_QodcKV5WSk9QvajX4LJ_AmxDg2-HfXvbAWzxjc0ZYkjYBzxrhi4n_ODzCl_bPESfn4tFSJDxhbc1ZEi4b3FeAV72Q3jEJ9eLi-XpMTpobZfg82udovvLn3fnv4v54tfV-WxeOK5ELmglS-uUkooIZxtSEVdpylwrqG65lVQqp4A5oCVlhGkQZVvLhnNnW3Cs4VP04yV3O9QbaByEHG1nttFvbHw2vfXm_0nwK_PYPxlKxmVMiTHh5DUh9n8GSNlsfHLQdTZAPyTDSiXLkmslR_TbO3TdDzGM_42UJlRJSnfU6QvlYp9ShHZ_DSVmp87s1JmdupH9-vb8PfnPFf8LASmTag</recordid><startdate>20230301</startdate><enddate>20230301</enddate><creator>Arosemena, Marilyn</creator><creator>Salguero, Maria V</creator><creator>Naylor, Rochelle N</creator><creator>Wroblewski, Kristen</creator><creator>Tasali, Esra</creator><creator>Philipson, Louis H</creator><general>American Diabetes Association</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>K9.</scope><scope>NAPCQ</scope><scope>7X8</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0002-8185-4707</orcidid></search><sort><creationdate>20230301</creationdate><title>Objective and Subjective Sleep Patterns in Adults With Maturity-Onset Diabetes of the Young (MODY)</title><author>Arosemena, Marilyn ; Salguero, Maria V ; Naylor, Rochelle N ; Wroblewski, Kristen ; Tasali, Esra ; Philipson, Louis H</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c364t-1957ac665604cad090c9812cf418f3a5156c6e2ce1712028e47fb5d33cafec2d3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2023</creationdate><topic>Adults</topic><topic>Apnea</topic><topic>Brief Report</topic><topic>Diabetes</topic><topic>Diabetes mellitus</topic><topic>Diabetes Mellitus, Type 2 - complications</topic><topic>Diabetes Mellitus, Type 2 - epidemiology</topic><topic>Female</topic><topic>Glucokinase</topic><topic>Glucokinase - genetics</topic><topic>Health risks</topic><topic>Hepatocyte Nuclear Factor 1-alpha - genetics</topic><topic>Hepatocyte nuclear factor 4</topic><topic>Humans</topic><topic>Insomnia</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Mutation</topic><topic>Night</topic><topic>Research design</topic><topic>Risk Factors</topic><topic>Sleep</topic><topic>Sleep and wakefulness</topic><topic>Sleep apnea</topic><topic>Sleep disorders</topic><topic>Sleep Disorders, Intrinsic - etiology</topic><topic>Wrist</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Arosemena, Marilyn</creatorcontrib><creatorcontrib>Salguero, Maria V</creatorcontrib><creatorcontrib>Naylor, Rochelle N</creatorcontrib><creatorcontrib>Wroblewski, Kristen</creatorcontrib><creatorcontrib>Tasali, Esra</creatorcontrib><creatorcontrib>Philipson, Louis H</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Premium</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Diabetes care</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Arosemena, Marilyn</au><au>Salguero, Maria V</au><au>Naylor, Rochelle N</au><au>Wroblewski, Kristen</au><au>Tasali, Esra</au><au>Philipson, Louis H</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Objective and Subjective Sleep Patterns in Adults With Maturity-Onset Diabetes of the Young (MODY)</atitle><jtitle>Diabetes care</jtitle><addtitle>Diabetes Care</addtitle><date>2023-03-01</date><risdate>2023</risdate><volume>46</volume><issue>3</issue><spage>608</spage><epage>612</epage><pages>608-612</pages><issn>0149-5992</issn><eissn>1935-5548</eissn><abstract>To examine sleep patterns in adults with maturity-onset diabetes of the young (MODY).
Adults with glucokinase (GCK)-MODY and transcription factor (TF)-related MODY (HNF1A, HNF1B, HNF4A) were recruited (n = 24; age 46.0 years, 79% women, BMI 24.7 kg/m2) from The University of Chicago's Monogenic Diabetes Registry. Sleep patterns were assessed by 2-week wrist actigraphy (total 315 nights), one night of a home sleep apnea test, and validated surveys.
Overall, compared with established criteria, 29% of participants had sleep latency ≥15 min, 38% had sleep efficiency ≤85%, 46% had wake after sleep onset >40 min, all indicating poor objective sleep quality. Among all participants, 54% had a sleep duration below the recommended minimum of 7 h, 88% reported poor sleep quality, 58% had obstructive sleep apnea, and 71% reported insomnia. Compared with GCK-MODY, participants with TF-related MODY had poorer objective sleep quality and increased night-to-night variability in sleep patterns.
Sleep disturbances appear to be common in adults with MODY despite absent traditional risk factors for sleep disorders. Future research investigating the sleep-diabetes relationship is warranted in this population.</abstract><cop>United States</cop><pub>American Diabetes Association</pub><pmid>36637968</pmid><doi>10.2337/dc22-1343</doi><tpages>5</tpages><orcidid>https://orcid.org/0000-0002-8185-4707</orcidid><oa>free_for_read</oa></addata></record> |
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| ispartof | Diabetes care, 2023-03, Vol.46 (3), p.608-612 |
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| subjects | Adults Apnea Brief Report Diabetes Diabetes mellitus Diabetes Mellitus, Type 2 - complications Diabetes Mellitus, Type 2 - epidemiology Female Glucokinase Glucokinase - genetics Health risks Hepatocyte Nuclear Factor 1-alpha - genetics Hepatocyte nuclear factor 4 Humans Insomnia Male Middle Aged Mutation Night Research design Risk Factors Sleep Sleep and wakefulness Sleep apnea Sleep disorders Sleep Disorders, Intrinsic - etiology Wrist |
| title | Objective and Subjective Sleep Patterns in Adults With Maturity-Onset Diabetes of the Young (MODY) |
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