A comprehensive pharmacogenomic study indicates roles for SLCO1B1, ABCG2 and SLCO2B1 in rosuvastatin pharmacokinetics

Aims The aim was to comprehensively investigate the effects of genetic variability on the pharmacokinetics of rosuvastatin. Methods We conducted a genome‐wide association study and candidate gene analyses of single dose rosuvastatin pharmacokinetics in a prospective study (n = 159) and a cohort of p...

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Veröffentlicht in:	British journal of clinical pharmacology 2023-01, Vol.89 (1), p.242-252
Hauptverfasser:	Lehtisalo, Minna, Taskinen, Suvi, Tarkiainen, E. Katriina, Neuvonen, Mikko, Viinamäki, Jenni, Paile‐Hyvärinen, Maria, Lilius, Tuomas O., Tapaninen, Tuija, Backman, Janne T., Tornio, Aleksi, Niemi, Mikko
Format:	Artikel
Sprache:	eng
Schlagworte:	ABCG2 Genome-Wide Association Study Genotype Organic Anion Transporters - genetics Original Pharmacogenomic Testing pharmacogenomics Polymorphism, Single Nucleotide Prospective Studies rosuvastatin Rosuvastatin Calcium - pharmacokinetics SLCO1B1 SLCO2B1
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