Humidity during high‐frequency oscillatory ventilation compared to intermittent positive pressure ventilation in extremely preterm neonates: An in vitro and in vivo observational study
Background Inappropriate humidification of inspired gas during mechanical ventilation can impair lung development in extremely low birthweight (ELBW) infants. Humidification depends on multiple factors, such as the heater‐humidifier device used, type of ventilation, and environmental factors. Few st...
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| Veröffentlicht in: | Pediatric pulmonology 2023-01, Vol.58 (1), p.66-72 |
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| creator | Danan, Claude Tauzin, Manon Jung, Camille Durrmeyer, Xavier Caeymaex, Laurence Treussart, Charles Decobert, Fabrice Louis, Bruno |
| description | Background
Inappropriate humidification of inspired gas during mechanical ventilation can impair lung development in extremely low birthweight (ELBW) infants. Humidification depends on multiple factors, such as the heater‐humidifier device used, type of ventilation, and environmental factors. Few studies have examined inspired gas humidification in these infants, especially during high‐frequency oscillatory ventilation (HFOV). Our objective was to compare humidity during HFOV and intermittent positive pressure ventilation (IPPV), in vitro and in vivo.
Methods
In vitro and in vivo studies used the same ventilator during both HFOV and IPPV. The bench study used a neonatal test lung and two heater‐humidifiers with their specific circuits; the in vivo study prospectively included preterm infants born before 28 weeks of gestation.
Results
On bench testing, mean absolute (AH) and relative (RH) humidity values were significantly lower during HFOV than IPPV (RH = 79.4 ± 8.1% vs. 89.0 ± 6.2%, p |
| doi_str_mv | 10.1002/ppul.26157 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_10086959</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2754761317</sourcerecordid><originalsourceid>FETCH-LOGICAL-c4427-32ee2795adfff166485967e6f9c776d627e94810fd3379b22955fd16da5db1823</originalsourceid><addsrcrecordid>eNp9kk1u1DAUxyMEokNhwwGQJTaAlGI7iR13g0YVMEgj0QVdW574ZcZVEgfbCWTHETgPx-EkOJNS0S5Y-eP93v99Jslzgs8IxvRt3w_NGWWk4A-SFcFCpDgX7GGyKnlRpKxk2UnyxPtrjKNNkMfJScYIpqzkq-TXZmiNNmFCenCm26OD2R9-__hZO_g6QFdNyPrKNI0K1k1ohC6YeDe2Q5Vte-VAo2CR6QK41oQQ7ai33gQzAuodeD84uONmOgTfg4MWmmkmZkfUge1UAH-O1kdiNMFZpDq9PEaL7M6DG48SqkE-DHp6mjyqVePh2c15mlx9eP_lYpNuP3_8dLHeplWeU55mFIByUShd1zVhLC8LwTiwWlScM80oB5GXBNc6y7jYUSqKotaEaVXoHSlpdpq8W3T7YdeCrmIxTjWyd6ZVbpJWGXnX0pmD3NtRxuGUTBQiKrxeFA73_DbrrZz_cJ5hToUYSWRf3URzNk7AB9kaX0GcQGzS4CXlJM8EKUkW0Zf30Gs7uNifmSpyzkhGeKTeLFTlrPcO6tsMCJ5TpHLeH3ncnwi_-LfWW_TvwkSALMA308D0Hyl5eXm1XUT_APZS16M</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2754761317</pqid></control><display><type>article</type><title>Humidity during high‐frequency oscillatory ventilation compared to intermittent positive pressure ventilation in extremely preterm neonates: An in vitro and in vivo observational study</title><source>MEDLINE</source><source>Wiley Online Library Journals Frontfile Complete</source><creator>Danan, Claude ; Tauzin, Manon ; Jung, Camille ; Durrmeyer, Xavier ; Caeymaex, Laurence ; Treussart, Charles ; Decobert, Fabrice ; Louis, Bruno</creator><creatorcontrib>Danan, Claude ; Tauzin, Manon ; Jung, Camille ; Durrmeyer, Xavier ; Caeymaex, Laurence ; Treussart, Charles ; Decobert, Fabrice ; Louis, Bruno</creatorcontrib><description>Background
Inappropriate humidification of inspired gas during mechanical ventilation can impair lung development in extremely low birthweight (ELBW) infants. Humidification depends on multiple factors, such as the heater‐humidifier device used, type of ventilation, and environmental factors. Few studies have examined inspired gas humidification in these infants, especially during high‐frequency oscillatory ventilation (HFOV). Our objective was to compare humidity during HFOV and intermittent positive pressure ventilation (IPPV), in vitro and in vivo.
Methods
In vitro and in vivo studies used the same ventilator during both HFOV and IPPV. The bench study used a neonatal test lung and two heater‐humidifiers with their specific circuits; the in vivo study prospectively included preterm infants born before 28 weeks of gestation.
Results
On bench testing, mean absolute (AH) and relative (RH) humidity values were significantly lower during HFOV than IPPV (RH = 79.4 ± 8.1% vs. 89.0 ± 6.2%, p < 0.001). Regardless of the ventilatory mode, mean RH significantly differed between the two heater‐humidifiers (89.6 ± 6.7% vs 78.7 ± 6.8%, p = 0.003). The in vivo study included 10 neonates (mean ± SD gestational age: 25.7 ± 0.9 weeks and birthweight: 624.4 ± 96.1 g). Mean RH during HFOV was significantly lower than during IPPV (74.6 ± 5.7% vs. 83.0 ± 6.7%, p = 0.004).
Conclusion
RH was significantly lower during HFOV than IPPV, both in vitro and in vivo. The type of heater‐humidifier also influenced humidification. More systematic measurements of humidity of inspired gas, especially during HFOV, should be considered to optimize humidification and consequently lung protection in ELBW infants.</description><identifier>ISSN: 8755-6863</identifier><identifier>EISSN: 1099-0496</identifier><identifier>DOI: 10.1002/ppul.26157</identifier><identifier>PMID: 36102687</identifier><language>eng</language><publisher>United States: Wiley Subscription Services, Inc</publisher><subject>Birth weight ; ELBW ; HFOV ; High-Frequency Ventilation ; Humans ; humidification ; Humidity ; Infant ; Infant, Extremely Premature ; Infant, Newborn ; Intermittent Positive-Pressure Ventilation ; Life Sciences ; Observational studies ; Original ; Respiratory Distress Syndrome, Newborn - therapy ; Ventilators</subject><ispartof>Pediatric pulmonology, 2023-01, Vol.58 (1), p.66-72</ispartof><rights>2022 The Authors. published by Wiley Periodicals LLC.</rights><rights>2022 The Authors. Pediatric Pulmonology published by Wiley Periodicals LLC.</rights><rights>2022. This article is published under http://creativecommons.org/licenses/by-nc-nd/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>Distributed under a Creative Commons Attribution 4.0 International License</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c4427-32ee2795adfff166485967e6f9c776d627e94810fd3379b22955fd16da5db1823</cites><orcidid>0000-0001-9204-5713 ; 0000-0003-0547-4566</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fppul.26157$$EPDF$$P50$$Gwiley$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fppul.26157$$EHTML$$P50$$Gwiley$$Hfree_for_read</linktohtml><link.rule.ids>230,314,776,780,881,1411,27901,27902,45550,45551</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/36102687$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink><backlink>$$Uhttps://hal.u-pec.fr/hal-04307299$$DView record in HAL$$Hfree_for_read</backlink></links><search><creatorcontrib>Danan, Claude</creatorcontrib><creatorcontrib>Tauzin, Manon</creatorcontrib><creatorcontrib>Jung, Camille</creatorcontrib><creatorcontrib>Durrmeyer, Xavier</creatorcontrib><creatorcontrib>Caeymaex, Laurence</creatorcontrib><creatorcontrib>Treussart, Charles</creatorcontrib><creatorcontrib>Decobert, Fabrice</creatorcontrib><creatorcontrib>Louis, Bruno</creatorcontrib><title>Humidity during high‐frequency oscillatory ventilation compared to intermittent positive pressure ventilation in extremely preterm neonates: An in vitro and in vivo observational study</title><title>Pediatric pulmonology</title><addtitle>Pediatr Pulmonol</addtitle><description>Background
Inappropriate humidification of inspired gas during mechanical ventilation can impair lung development in extremely low birthweight (ELBW) infants. Humidification depends on multiple factors, such as the heater‐humidifier device used, type of ventilation, and environmental factors. Few studies have examined inspired gas humidification in these infants, especially during high‐frequency oscillatory ventilation (HFOV). Our objective was to compare humidity during HFOV and intermittent positive pressure ventilation (IPPV), in vitro and in vivo.
Methods
In vitro and in vivo studies used the same ventilator during both HFOV and IPPV. The bench study used a neonatal test lung and two heater‐humidifiers with their specific circuits; the in vivo study prospectively included preterm infants born before 28 weeks of gestation.
Results
On bench testing, mean absolute (AH) and relative (RH) humidity values were significantly lower during HFOV than IPPV (RH = 79.4 ± 8.1% vs. 89.0 ± 6.2%, p < 0.001). Regardless of the ventilatory mode, mean RH significantly differed between the two heater‐humidifiers (89.6 ± 6.7% vs 78.7 ± 6.8%, p = 0.003). The in vivo study included 10 neonates (mean ± SD gestational age: 25.7 ± 0.9 weeks and birthweight: 624.4 ± 96.1 g). Mean RH during HFOV was significantly lower than during IPPV (74.6 ± 5.7% vs. 83.0 ± 6.7%, p = 0.004).
Conclusion
RH was significantly lower during HFOV than IPPV, both in vitro and in vivo. The type of heater‐humidifier also influenced humidification. More systematic measurements of humidity of inspired gas, especially during HFOV, should be considered to optimize humidification and consequently lung protection in ELBW infants.</description><subject>Birth weight</subject><subject>ELBW</subject><subject>HFOV</subject><subject>High-Frequency Ventilation</subject><subject>Humans</subject><subject>humidification</subject><subject>Humidity</subject><subject>Infant</subject><subject>Infant, Extremely Premature</subject><subject>Infant, Newborn</subject><subject>Intermittent Positive-Pressure Ventilation</subject><subject>Life Sciences</subject><subject>Observational studies</subject><subject>Original</subject><subject>Respiratory Distress Syndrome, Newborn - therapy</subject><subject>Ventilators</subject><issn>8755-6863</issn><issn>1099-0496</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2023</creationdate><recordtype>article</recordtype><sourceid>24P</sourceid><sourceid>EIF</sourceid><recordid>eNp9kk1u1DAUxyMEokNhwwGQJTaAlGI7iR13g0YVMEgj0QVdW574ZcZVEgfbCWTHETgPx-EkOJNS0S5Y-eP93v99Jslzgs8IxvRt3w_NGWWk4A-SFcFCpDgX7GGyKnlRpKxk2UnyxPtrjKNNkMfJScYIpqzkq-TXZmiNNmFCenCm26OD2R9-__hZO_g6QFdNyPrKNI0K1k1ohC6YeDe2Q5Vte-VAo2CR6QK41oQQ7ai33gQzAuodeD84uONmOgTfg4MWmmkmZkfUge1UAH-O1kdiNMFZpDq9PEaL7M6DG48SqkE-DHp6mjyqVePh2c15mlx9eP_lYpNuP3_8dLHeplWeU55mFIByUShd1zVhLC8LwTiwWlScM80oB5GXBNc6y7jYUSqKotaEaVXoHSlpdpq8W3T7YdeCrmIxTjWyd6ZVbpJWGXnX0pmD3NtRxuGUTBQiKrxeFA73_DbrrZz_cJ5hToUYSWRf3URzNk7AB9kaX0GcQGzS4CXlJM8EKUkW0Zf30Gs7uNifmSpyzkhGeKTeLFTlrPcO6tsMCJ5TpHLeH3ncnwi_-LfWW_TvwkSALMA308D0Hyl5eXm1XUT_APZS16M</recordid><startdate>202301</startdate><enddate>202301</enddate><creator>Danan, Claude</creator><creator>Tauzin, Manon</creator><creator>Jung, Camille</creator><creator>Durrmeyer, Xavier</creator><creator>Caeymaex, Laurence</creator><creator>Treussart, Charles</creator><creator>Decobert, Fabrice</creator><creator>Louis, Bruno</creator><general>Wiley Subscription Services, Inc</general><general>Wiley</general><general>John Wiley and Sons Inc</general><scope>24P</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>K9.</scope><scope>7X8</scope><scope>1XC</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0001-9204-5713</orcidid><orcidid>https://orcid.org/0000-0003-0547-4566</orcidid></search><sort><creationdate>202301</creationdate><title>Humidity during high‐frequency oscillatory ventilation compared to intermittent positive pressure ventilation in extremely preterm neonates: An in vitro and in vivo observational study</title><author>Danan, Claude ; Tauzin, Manon ; Jung, Camille ; Durrmeyer, Xavier ; Caeymaex, Laurence ; Treussart, Charles ; Decobert, Fabrice ; Louis, Bruno</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4427-32ee2795adfff166485967e6f9c776d627e94810fd3379b22955fd16da5db1823</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2023</creationdate><topic>Birth weight</topic><topic>ELBW</topic><topic>HFOV</topic><topic>High-Frequency Ventilation</topic><topic>Humans</topic><topic>humidification</topic><topic>Humidity</topic><topic>Infant</topic><topic>Infant, Extremely Premature</topic><topic>Infant, Newborn</topic><topic>Intermittent Positive-Pressure Ventilation</topic><topic>Life Sciences</topic><topic>Observational studies</topic><topic>Original</topic><topic>Respiratory Distress Syndrome, Newborn - therapy</topic><topic>Ventilators</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Danan, Claude</creatorcontrib><creatorcontrib>Tauzin, Manon</creatorcontrib><creatorcontrib>Jung, Camille</creatorcontrib><creatorcontrib>Durrmeyer, Xavier</creatorcontrib><creatorcontrib>Caeymaex, Laurence</creatorcontrib><creatorcontrib>Treussart, Charles</creatorcontrib><creatorcontrib>Decobert, Fabrice</creatorcontrib><creatorcontrib>Louis, Bruno</creatorcontrib><collection>Wiley Online Library Open Access</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>MEDLINE - Academic</collection><collection>Hyper Article en Ligne (HAL)</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Pediatric pulmonology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Danan, Claude</au><au>Tauzin, Manon</au><au>Jung, Camille</au><au>Durrmeyer, Xavier</au><au>Caeymaex, Laurence</au><au>Treussart, Charles</au><au>Decobert, Fabrice</au><au>Louis, Bruno</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Humidity during high‐frequency oscillatory ventilation compared to intermittent positive pressure ventilation in extremely preterm neonates: An in vitro and in vivo observational study</atitle><jtitle>Pediatric pulmonology</jtitle><addtitle>Pediatr Pulmonol</addtitle><date>2023-01</date><risdate>2023</risdate><volume>58</volume><issue>1</issue><spage>66</spage><epage>72</epage><pages>66-72</pages><issn>8755-6863</issn><eissn>1099-0496</eissn><abstract>Background
Inappropriate humidification of inspired gas during mechanical ventilation can impair lung development in extremely low birthweight (ELBW) infants. Humidification depends on multiple factors, such as the heater‐humidifier device used, type of ventilation, and environmental factors. Few studies have examined inspired gas humidification in these infants, especially during high‐frequency oscillatory ventilation (HFOV). Our objective was to compare humidity during HFOV and intermittent positive pressure ventilation (IPPV), in vitro and in vivo.
Methods
In vitro and in vivo studies used the same ventilator during both HFOV and IPPV. The bench study used a neonatal test lung and two heater‐humidifiers with their specific circuits; the in vivo study prospectively included preterm infants born before 28 weeks of gestation.
Results
On bench testing, mean absolute (AH) and relative (RH) humidity values were significantly lower during HFOV than IPPV (RH = 79.4 ± 8.1% vs. 89.0 ± 6.2%, p < 0.001). Regardless of the ventilatory mode, mean RH significantly differed between the two heater‐humidifiers (89.6 ± 6.7% vs 78.7 ± 6.8%, p = 0.003). The in vivo study included 10 neonates (mean ± SD gestational age: 25.7 ± 0.9 weeks and birthweight: 624.4 ± 96.1 g). Mean RH during HFOV was significantly lower than during IPPV (74.6 ± 5.7% vs. 83.0 ± 6.7%, p = 0.004).
Conclusion
RH was significantly lower during HFOV than IPPV, both in vitro and in vivo. The type of heater‐humidifier also influenced humidification. More systematic measurements of humidity of inspired gas, especially during HFOV, should be considered to optimize humidification and consequently lung protection in ELBW infants.</abstract><cop>United States</cop><pub>Wiley Subscription Services, Inc</pub><pmid>36102687</pmid><doi>10.1002/ppul.26157</doi><tpages>7</tpages><orcidid>https://orcid.org/0000-0001-9204-5713</orcidid><orcidid>https://orcid.org/0000-0003-0547-4566</orcidid><oa>free_for_read</oa></addata></record> |
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| source | MEDLINE; Wiley Online Library Journals Frontfile Complete |
| subjects | Birth weight ELBW HFOV High-Frequency Ventilation Humans humidification Humidity Infant Infant, Extremely Premature Infant, Newborn Intermittent Positive-Pressure Ventilation Life Sciences Observational studies Original Respiratory Distress Syndrome, Newborn - therapy Ventilators |
| title | Humidity during high‐frequency oscillatory ventilation compared to intermittent positive pressure ventilation in extremely preterm neonates: An in vitro and in vivo observational study |
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