Evidence that RXFP4 is located in enterochromaffin cells and can regulate production and release of serotonin

RXFP4 is a G protein-coupled receptor (GPCR) in the relaxin family. It has recently been recognised that this receptor and its cognate ligand INSL5 may have a role in the regulation of food intake, gut motility, and other functions relevant to metabolic health and disease. Recent data from reporter-...

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Veröffentlicht in:	Bioscience reports 2023-04, Vol.43 (4), p.1
Hauptverfasser:	Fernando, Shalinda J A, Wang, Qian, Hay, Debbie L, Bathgate, Ross A D, Shepherd, Peter R, Lee, Kate L
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antibodies Constipation Cyclic AMP Datasets Endocrinology Enterochromaffin Cells - metabolism Food intake Forskolin G protein-coupled receptors Gastric motility Gastrointestinal, Renal & Hepatic Systems Gene expression Humans Insulin Insulin - metabolism Insulin-like growth factors Laboratory animals Ligands Mice Motility mRNA Nucleotide sequence Peptides Receptors Receptors, G-Protein-Coupled - genetics Receptors, G-Protein-Coupled - metabolism Receptors, Peptide - chemistry Receptors, Peptide - genetics Receptors, Peptide - metabolism Relaxin RNA, Messenger - genetics Serotonin Serotonin - metabolism
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