When translation elongation is impaired, the mRNA is uniformly destabilized by the RNA degradosome, while the concentration of mRNA is altered along the molecule

Abstract mRNA sits at the crossroads of transcription, translation and mRNA degradation. Many questions remain about the coupling of these three processes in Escherichia coli and, in particular, how translation may have an effect on mRNA degradation and transcription. To characterize the interplay b...

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Veröffentlicht in:	Nucleic acids research 2023-04, Vol.51 (6), p.2877-2890
Hauptverfasser:	Duviau, Marie-Pierre, Chen, Fan, Emile, Anthony, Cocaign-Bousquet, Muriel, Girbal, Laurence, Nouaille, Sébastien
Format:	Artikel
Sprache:	eng
Schlagworte:	Bacteriology Biochemistry, Molecular Biology Codon, Terminator - metabolism Endoribonucleases - genetics Endoribonucleases - metabolism Escherichia coli - genetics Escherichia coli - metabolism Genomics Life Sciences Microbiology and Parasitology Peptide Chain Elongation, Translational Protein Biosynthesis RNA and RNA-protein complexes RNA, Messenger - genetics RNA, Messenger - metabolism
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