Severe hyperferremia and hyperferritinemia in a dog with precursor‐directed immune‐mediated anemia
A 4‐year‐old dog was evaluated at the Colorado State University Veterinary Teaching Hospital for lethargy and hyporexia of 24 hours duration. On presentation, she had a marked normocytic, normochromic, nonregenerative anemia (HCT 14%; RI 40–55). Her serum iron concentration (1651 μg/dL; RI 73–245) a...
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| Veröffentlicht in: | Veterinary clinical pathology 2022-12, Vol.51 (4), p.491-494 |
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| container_title | Veterinary clinical pathology |
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| creator | Zersen, Kristin M. Gregory, Carly W. Jeffries, Christina M. Olver, Christine |
| description | A 4‐year‐old dog was evaluated at the Colorado State University Veterinary Teaching Hospital for lethargy and hyporexia of 24 hours duration. On presentation, she had a marked normocytic, normochromic, nonregenerative anemia (HCT 14%; RI 40–55). Her serum iron concentration (1651 μg/dL; RI 73–245) and serum ferritin concentration (1337 ng/mL; RI 89–489) were markedly elevated. Bone marrow aspirate and core biopsy were consistent with a diagnosis of precursor‐directed immune‐mediate anemia. To the authors' knowledge, these are the highest reported serum iron and ferritin concentrations in a patient with precursor‐directed immune‐mediate anemia. The iron concentration improved significantly after treatment, supporting the theory that the hyperferremia was due to hemolysis and ineffective erythropoiesis. |
| doi_str_mv | 10.1111/vcp.13130 |
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On presentation, she had a marked normocytic, normochromic, nonregenerative anemia (HCT 14%; RI 40–55). Her serum iron concentration (1651 μg/dL; RI 73–245) and serum ferritin concentration (1337 ng/mL; RI 89–489) were markedly elevated. Bone marrow aspirate and core biopsy were consistent with a diagnosis of precursor‐directed immune‐mediate anemia. To the authors' knowledge, these are the highest reported serum iron and ferritin concentrations in a patient with precursor‐directed immune‐mediate anemia. 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| ispartof | Veterinary clinical pathology, 2022-12, Vol.51 (4), p.491-494 |
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| source | MEDLINE; Access via Wiley Online Library |
| subjects | Anemia - etiology Anemia - veterinary Animals Case Report Dog Diseases - diagnosis Dogs Female ferritin Ferritins Hematology Hospitals, Animal Hospitals, Teaching Hyperferritinemia - veterinary Iron nonregenerative anemia |
| title | Severe hyperferremia and hyperferritinemia in a dog with precursor‐directed immune‐mediated anemia |
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