Long-term levodopa ameliorates sequence effect in simple, but not complex walking in early Parkinson's disease patients
The sequence effect (SE) is characterized by the progressive decrement of movements and is often observed in Parkinson's disease (PD) patients. While acute effect of levodopa does not ameliorate the SE, the effect of long-term levodopa treatment for the SE remains unknown. We aimed to elucidate...
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| Veröffentlicht in: | Parkinsonism & related disorders 2023-03, Vol.108, p.105322-105322, Article 105322 |
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| creator | Ohara, Masahiro Hirata, Kosei Hallett, Mark Matsubayashi, Taiki Chen, Qingmeng Kina, Satoko Shimano, Kaoru Hirakawa, Akihiro Yokota, Takanori Hattori, Takaaki |
| description | The sequence effect (SE) is characterized by the progressive decrement of movements and is often observed in Parkinson's disease (PD) patients. While acute effect of levodopa does not ameliorate the SE, the effect of long-term levodopa treatment for the SE remains unknown.
We aimed to elucidate the SEs during various gait conditions and their response to long-term levodopa treatment in drug-naïve PD patients.
Nineteen drug-naïve PD patients and 21 healthy controls were enrolled. Gait parameters were measured via wearable inertial sensors in the following conditions:1) straight walking, 2) circular walking: walking a circle of 1 m diameter in a clock-wise direction for 3 laps, 3) straight or circular walking under cognitive-motor dual-task (serial 7s subtractions). PD patients were evaluated at baseline, within 1 h after intravenous administration of levodopa, and after one, three, and six months treatment with levodopa. The SE was measured by a linear regression slope by plotting consecutive stride lengths over steps. Patients were also separately analyzed depending on laterality of symptoms.
Long-term levodopa treatment ameliorated the SE only during single-task straight walking. The SE during circular walking was exacerbated after long-term levodopa treatment for right-side dominant patients. During dual-task straight walking, the SE at baseline was greater in right-side dominant PD patients.
The SE only during single-task straight walking can be ameliorated by long-term levodopa treatment. However, the SE may be exaggerated by cognitive motor interference or by asymmetrical stride length with/without long-term levodopa treatment, depending on the laterality of symptoms.
•Long-term levodopa can improve the sequence effect in Parkinson's disease patients.•The improvement in the sequence effect depends on the gait conditions.•The sequence effect may be exaggerated by asymmetrical stride length.•The sequence effect may be exaggerated by cognitive motor interference. |
| doi_str_mv | 10.1016/j.parkreldis.2023.105322 |
| format | Article |
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We aimed to elucidate the SEs during various gait conditions and their response to long-term levodopa treatment in drug-naïve PD patients.
Nineteen drug-naïve PD patients and 21 healthy controls were enrolled. Gait parameters were measured via wearable inertial sensors in the following conditions:1) straight walking, 2) circular walking: walking a circle of 1 m diameter in a clock-wise direction for 3 laps, 3) straight or circular walking under cognitive-motor dual-task (serial 7s subtractions). PD patients were evaluated at baseline, within 1 h after intravenous administration of levodopa, and after one, three, and six months treatment with levodopa. The SE was measured by a linear regression slope by plotting consecutive stride lengths over steps. Patients were also separately analyzed depending on laterality of symptoms.
Long-term levodopa treatment ameliorated the SE only during single-task straight walking. The SE during circular walking was exacerbated after long-term levodopa treatment for right-side dominant patients. During dual-task straight walking, the SE at baseline was greater in right-side dominant PD patients.
The SE only during single-task straight walking can be ameliorated by long-term levodopa treatment. However, the SE may be exaggerated by cognitive motor interference or by asymmetrical stride length with/without long-term levodopa treatment, depending on the laterality of symptoms.
•Long-term levodopa can improve the sequence effect in Parkinson's disease patients.•The improvement in the sequence effect depends on the gait conditions.•The sequence effect may be exaggerated by asymmetrical stride length.•The sequence effect may be exaggerated by cognitive motor interference.</description><identifier>ISSN: 1353-8020</identifier><identifier>EISSN: 1873-5126</identifier><identifier>DOI: 10.1016/j.parkreldis.2023.105322</identifier><identifier>PMID: 36822140</identifier><language>eng</language><publisher>England: Elsevier Ltd</publisher><subject>Gait - physiology ; Gait analysis ; Gait Disorders, Neurologic ; Humans ; Levodopa ; Levodopa - pharmacology ; Parkinson Disease ; Parkinson's disease ; Sequence effect ; Walking - physiology</subject><ispartof>Parkinsonism & related disorders, 2023-03, Vol.108, p.105322-105322, Article 105322</ispartof><rights>2023 Elsevier Ltd</rights><rights>Copyright © 2023 Elsevier Ltd. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c430t-eb23520d39124564628a258383429c3bfb4d2f49a524e07c61fd86a37ffe40e03</citedby><cites>FETCH-LOGICAL-c430t-eb23520d39124564628a258383429c3bfb4d2f49a524e07c61fd86a37ffe40e03</cites><orcidid>0000-0002-3180-6811 ; 0000-0002-4802-8606 ; 0000-0002-5702-0331 ; 0000-0003-0344-251X</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.parkreldis.2023.105322$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>230,315,781,785,886,3551,27926,27927,45997</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/36822140$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Ohara, Masahiro</creatorcontrib><creatorcontrib>Hirata, Kosei</creatorcontrib><creatorcontrib>Hallett, Mark</creatorcontrib><creatorcontrib>Matsubayashi, Taiki</creatorcontrib><creatorcontrib>Chen, Qingmeng</creatorcontrib><creatorcontrib>Kina, Satoko</creatorcontrib><creatorcontrib>Shimano, Kaoru</creatorcontrib><creatorcontrib>Hirakawa, Akihiro</creatorcontrib><creatorcontrib>Yokota, Takanori</creatorcontrib><creatorcontrib>Hattori, Takaaki</creatorcontrib><title>Long-term levodopa ameliorates sequence effect in simple, but not complex walking in early Parkinson's disease patients</title><title>Parkinsonism & related disorders</title><addtitle>Parkinsonism Relat Disord</addtitle><description>The sequence effect (SE) is characterized by the progressive decrement of movements and is often observed in Parkinson's disease (PD) patients. While acute effect of levodopa does not ameliorate the SE, the effect of long-term levodopa treatment for the SE remains unknown.
We aimed to elucidate the SEs during various gait conditions and their response to long-term levodopa treatment in drug-naïve PD patients.
Nineteen drug-naïve PD patients and 21 healthy controls were enrolled. Gait parameters were measured via wearable inertial sensors in the following conditions:1) straight walking, 2) circular walking: walking a circle of 1 m diameter in a clock-wise direction for 3 laps, 3) straight or circular walking under cognitive-motor dual-task (serial 7s subtractions). PD patients were evaluated at baseline, within 1 h after intravenous administration of levodopa, and after one, three, and six months treatment with levodopa. The SE was measured by a linear regression slope by plotting consecutive stride lengths over steps. Patients were also separately analyzed depending on laterality of symptoms.
Long-term levodopa treatment ameliorated the SE only during single-task straight walking. The SE during circular walking was exacerbated after long-term levodopa treatment for right-side dominant patients. During dual-task straight walking, the SE at baseline was greater in right-side dominant PD patients.
The SE only during single-task straight walking can be ameliorated by long-term levodopa treatment. However, the SE may be exaggerated by cognitive motor interference or by asymmetrical stride length with/without long-term levodopa treatment, depending on the laterality of symptoms.
•Long-term levodopa can improve the sequence effect in Parkinson's disease patients.•The improvement in the sequence effect depends on the gait conditions.•The sequence effect may be exaggerated by asymmetrical stride length.•The sequence effect may be exaggerated by cognitive motor interference.</description><subject>Gait - physiology</subject><subject>Gait analysis</subject><subject>Gait Disorders, Neurologic</subject><subject>Humans</subject><subject>Levodopa</subject><subject>Levodopa - pharmacology</subject><subject>Parkinson Disease</subject><subject>Parkinson's disease</subject><subject>Sequence effect</subject><subject>Walking - physiology</subject><issn>1353-8020</issn><issn>1873-5126</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2023</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkU9v1DAQxS1ERUvhKyDf4EC29thJvCdEK_5JK8EBzpbjTBZvHTvY2S399jjaUtoTJ9vjN2-e5kcI5WzFGW8udqvJpOuEvnd5BQxEKdcC4Ak546oVVc2heVruohaVYsBOyfOcd4yxtmbiGTkVjQLgkp2Rm00M22rGNFKPh9jHyVAzoncxmRkzzfhrj8EixWFAO1MXaHbj5PEt7fYzDXGmNi7v3_TG-GsXtosETfK39FvJ6EKO4XWmJSiajHQys8Mw5xfkZDA-48u785z8-Pjh-9XnavP105er95vKSsHmCjsQNbBerDnIupENKAO1EkpIWFvRDZ3sYZBrU4NE1tqGD71qjGhLWsmQiXPy7ug77bsRe1tmJ-P1lNxo0q2OxunHP8H91Nt40JwxBWuQxeHNnUOKZRd51qPLFr03AeM-a2hVkZYlqyJVR6lNMeeEw_0czvQCTu_0P3B6AaeP4Errq4c57xv_kiqCy6MAy7YODpPO1i1kepcKGN1H9_8pfwDJkbFa</recordid><startdate>20230301</startdate><enddate>20230301</enddate><creator>Ohara, Masahiro</creator><creator>Hirata, Kosei</creator><creator>Hallett, Mark</creator><creator>Matsubayashi, Taiki</creator><creator>Chen, Qingmeng</creator><creator>Kina, Satoko</creator><creator>Shimano, Kaoru</creator><creator>Hirakawa, Akihiro</creator><creator>Yokota, Takanori</creator><creator>Hattori, Takaaki</creator><general>Elsevier Ltd</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0002-3180-6811</orcidid><orcidid>https://orcid.org/0000-0002-4802-8606</orcidid><orcidid>https://orcid.org/0000-0002-5702-0331</orcidid><orcidid>https://orcid.org/0000-0003-0344-251X</orcidid></search><sort><creationdate>20230301</creationdate><title>Long-term levodopa ameliorates sequence effect in simple, but not complex walking in early Parkinson's disease patients</title><author>Ohara, Masahiro ; Hirata, Kosei ; Hallett, Mark ; Matsubayashi, Taiki ; Chen, Qingmeng ; Kina, Satoko ; Shimano, Kaoru ; Hirakawa, Akihiro ; Yokota, Takanori ; Hattori, Takaaki</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c430t-eb23520d39124564628a258383429c3bfb4d2f49a524e07c61fd86a37ffe40e03</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2023</creationdate><topic>Gait - physiology</topic><topic>Gait analysis</topic><topic>Gait Disorders, Neurologic</topic><topic>Humans</topic><topic>Levodopa</topic><topic>Levodopa - pharmacology</topic><topic>Parkinson Disease</topic><topic>Parkinson's disease</topic><topic>Sequence effect</topic><topic>Walking - physiology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Ohara, Masahiro</creatorcontrib><creatorcontrib>Hirata, Kosei</creatorcontrib><creatorcontrib>Hallett, Mark</creatorcontrib><creatorcontrib>Matsubayashi, Taiki</creatorcontrib><creatorcontrib>Chen, Qingmeng</creatorcontrib><creatorcontrib>Kina, Satoko</creatorcontrib><creatorcontrib>Shimano, Kaoru</creatorcontrib><creatorcontrib>Hirakawa, Akihiro</creatorcontrib><creatorcontrib>Yokota, Takanori</creatorcontrib><creatorcontrib>Hattori, Takaaki</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Parkinsonism & related disorders</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Ohara, Masahiro</au><au>Hirata, Kosei</au><au>Hallett, Mark</au><au>Matsubayashi, Taiki</au><au>Chen, Qingmeng</au><au>Kina, Satoko</au><au>Shimano, Kaoru</au><au>Hirakawa, Akihiro</au><au>Yokota, Takanori</au><au>Hattori, Takaaki</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Long-term levodopa ameliorates sequence effect in simple, but not complex walking in early Parkinson's disease patients</atitle><jtitle>Parkinsonism & related disorders</jtitle><addtitle>Parkinsonism Relat Disord</addtitle><date>2023-03-01</date><risdate>2023</risdate><volume>108</volume><spage>105322</spage><epage>105322</epage><pages>105322-105322</pages><artnum>105322</artnum><issn>1353-8020</issn><eissn>1873-5126</eissn><abstract>The sequence effect (SE) is characterized by the progressive decrement of movements and is often observed in Parkinson's disease (PD) patients. While acute effect of levodopa does not ameliorate the SE, the effect of long-term levodopa treatment for the SE remains unknown.
We aimed to elucidate the SEs during various gait conditions and their response to long-term levodopa treatment in drug-naïve PD patients.
Nineteen drug-naïve PD patients and 21 healthy controls were enrolled. Gait parameters were measured via wearable inertial sensors in the following conditions:1) straight walking, 2) circular walking: walking a circle of 1 m diameter in a clock-wise direction for 3 laps, 3) straight or circular walking under cognitive-motor dual-task (serial 7s subtractions). PD patients were evaluated at baseline, within 1 h after intravenous administration of levodopa, and after one, three, and six months treatment with levodopa. The SE was measured by a linear regression slope by plotting consecutive stride lengths over steps. Patients were also separately analyzed depending on laterality of symptoms.
Long-term levodopa treatment ameliorated the SE only during single-task straight walking. The SE during circular walking was exacerbated after long-term levodopa treatment for right-side dominant patients. During dual-task straight walking, the SE at baseline was greater in right-side dominant PD patients.
The SE only during single-task straight walking can be ameliorated by long-term levodopa treatment. However, the SE may be exaggerated by cognitive motor interference or by asymmetrical stride length with/without long-term levodopa treatment, depending on the laterality of symptoms.
•Long-term levodopa can improve the sequence effect in Parkinson's disease patients.•The improvement in the sequence effect depends on the gait conditions.•The sequence effect may be exaggerated by asymmetrical stride length.•The sequence effect may be exaggerated by cognitive motor interference.</abstract><cop>England</cop><pub>Elsevier Ltd</pub><pmid>36822140</pmid><doi>10.1016/j.parkreldis.2023.105322</doi><tpages>1</tpages><orcidid>https://orcid.org/0000-0002-3180-6811</orcidid><orcidid>https://orcid.org/0000-0002-4802-8606</orcidid><orcidid>https://orcid.org/0000-0002-5702-0331</orcidid><orcidid>https://orcid.org/0000-0003-0344-251X</orcidid></addata></record> |
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| ispartof | Parkinsonism & related disorders, 2023-03, Vol.108, p.105322-105322, Article 105322 |
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| source | MEDLINE; Access via ScienceDirect (Elsevier) |
| subjects | Gait - physiology Gait analysis Gait Disorders, Neurologic Humans Levodopa Levodopa - pharmacology Parkinson Disease Parkinson's disease Sequence effect Walking - physiology |
| title | Long-term levodopa ameliorates sequence effect in simple, but not complex walking in early Parkinson's disease patients |
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