Brain volumetrics differ by Fiebig stage in acute HIV infection
People with chronic HIV exhibit lower regional brain volumes compared to people without HIV (PWOH). Whether imaging alterations observed in chronic infection occur in acute HIV infection (AHI) remains unknown. Cross-sectional study of Thai participants with AHI. One hundred and twelve Thai males wit...
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| Veröffentlicht in: | AIDS (London) 2023-05, Vol.37 (6), p.861-869 |
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| creator | Bolzenius, Jacob Sacdalan, Carlo Ndhlovu, Lishomwa C. Sailasuta, Napapon Trautmann, Lydie Tipsuk, Somporn Crowell, Trevor A. Suttichom, Duanghathai Colby, Donn J. Phanuphak, Nittaya Chan, Phillip Premeaux, Thomas Kroon, Eugène Vasan, Sandhya Hsu, Denise C. Valcour, Victor Ananworanich, Jintanat Robb, Merlin L. Ake, Julie A. Pohl, Kilian M. Sriplienchan, Somchai Spudich, Serena Paul, Robert |
| description | People with chronic HIV exhibit lower regional brain volumes compared to people without HIV (PWOH). Whether imaging alterations observed in chronic infection occur in acute HIV infection (AHI) remains unknown.
Cross-sectional study of Thai participants with AHI.
One hundred and twelve Thai males with AHI (age 20-46) and 18 male Thai PWOH (age 18-40) were included. Individuals with AHI were stratified into early (Fiebig I-II; n = 32) and late (Fiebig III-V; n = 80) stages of acute infection using validated assays. T1-weighted scans were acquired using a 3 T MRI performed within five days of antiretroviral therapy (ART) initiation. Volumes for the amygdala, caudate nucleus, hippocampus, nucleus accumbens, pallidum, putamen, and thalamus were compared across groups.
Participants in late Fiebig stages exhibited larger volumes in the nucleus accumbens (8% larger; P = 0.049) and putamen (19%; P |
| doi_str_mv | 10.1097/QAD.0000000000003496 |
| format | Article |
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Cross-sectional study of Thai participants with AHI.
One hundred and twelve Thai males with AHI (age 20-46) and 18 male Thai PWOH (age 18-40) were included. Individuals with AHI were stratified into early (Fiebig I-II; n = 32) and late (Fiebig III-V; n = 80) stages of acute infection using validated assays. T1-weighted scans were acquired using a 3 T MRI performed within five days of antiretroviral therapy (ART) initiation. Volumes for the amygdala, caudate nucleus, hippocampus, nucleus accumbens, pallidum, putamen, and thalamus were compared across groups.
Participants in late Fiebig stages exhibited larger volumes in the nucleus accumbens (8% larger; P = 0.049) and putamen (19%; P < 0.001) when compared to participants in the early Fiebig. Compared to PWOH, participants in late Fiebig exhibited larger volumes of the amygdala (9% larger; P = 0.002), caudate nucleus (11%; P = 0.005), nucleus accumbens (15%; P = 0.004), pallidum (19%; P = 0.001), and putamen (31%; P < 0.001). Brain volumes in the nucleus accumbens, pallidum, and putamen correlated modestly with stimulant use over the past four months among late Fiebig individuals ( P s < 0.05).
Findings indicate that brain volume alterations occur in acute infection, with the most prominent differences evident in the later stages of AHI. Additional studies are needed to evaluate mechanisms for possible brain disruption following ART, including viral factors and markers of neuroinflammation.</description><identifier>ISSN: 0269-9370</identifier><identifier>EISSN: 1473-5571</identifier><identifier>DOI: 10.1097/QAD.0000000000003496</identifier><identifier>PMID: 36723491</identifier><language>eng</language><publisher>England: Lippincott Williams & Wilkins</publisher><subject>Adolescent ; Adult ; Brain - diagnostic imaging ; Cross-Sectional Studies ; HIV ; HIV Infections - complications ; HIV Infections - drug therapy ; Humans ; Magnetic Resonance Imaging - methods ; Male ; Middle Aged ; Young Adult</subject><ispartof>AIDS (London), 2023-05, Vol.37 (6), p.861-869</ispartof><rights>Lippincott Williams & Wilkins</rights><rights>Copyright © 2023 Wolters Kluwer Health, Inc. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4081-ac93f4a75e5ccdf35a1cde6ac4b94efc431e9a0597b88d6331b2ba48ad20d6aa3</citedby><cites>FETCH-LOGICAL-c4081-ac93f4a75e5ccdf35a1cde6ac4b94efc431e9a0597b88d6331b2ba48ad20d6aa3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>230,314,780,784,885,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/36723491$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Bolzenius, Jacob</creatorcontrib><creatorcontrib>Sacdalan, Carlo</creatorcontrib><creatorcontrib>Ndhlovu, Lishomwa C.</creatorcontrib><creatorcontrib>Sailasuta, Napapon</creatorcontrib><creatorcontrib>Trautmann, Lydie</creatorcontrib><creatorcontrib>Tipsuk, Somporn</creatorcontrib><creatorcontrib>Crowell, Trevor A.</creatorcontrib><creatorcontrib>Suttichom, Duanghathai</creatorcontrib><creatorcontrib>Colby, Donn J.</creatorcontrib><creatorcontrib>Phanuphak, Nittaya</creatorcontrib><creatorcontrib>Chan, Phillip</creatorcontrib><creatorcontrib>Premeaux, Thomas</creatorcontrib><creatorcontrib>Kroon, Eugène</creatorcontrib><creatorcontrib>Vasan, Sandhya</creatorcontrib><creatorcontrib>Hsu, Denise C.</creatorcontrib><creatorcontrib>Valcour, Victor</creatorcontrib><creatorcontrib>Ananworanich, Jintanat</creatorcontrib><creatorcontrib>Robb, Merlin L.</creatorcontrib><creatorcontrib>Ake, Julie A.</creatorcontrib><creatorcontrib>Pohl, Kilian M.</creatorcontrib><creatorcontrib>Sriplienchan, Somchai</creatorcontrib><creatorcontrib>Spudich, Serena</creatorcontrib><creatorcontrib>Paul, Robert</creatorcontrib><creatorcontrib>RV254/SEARCH010, RV304/SEARCH013 Study Teams</creatorcontrib><title>Brain volumetrics differ by Fiebig stage in acute HIV infection</title><title>AIDS (London)</title><addtitle>AIDS</addtitle><description>People with chronic HIV exhibit lower regional brain volumes compared to people without HIV (PWOH). Whether imaging alterations observed in chronic infection occur in acute HIV infection (AHI) remains unknown.
Cross-sectional study of Thai participants with AHI.
One hundred and twelve Thai males with AHI (age 20-46) and 18 male Thai PWOH (age 18-40) were included. Individuals with AHI were stratified into early (Fiebig I-II; n = 32) and late (Fiebig III-V; n = 80) stages of acute infection using validated assays. T1-weighted scans were acquired using a 3 T MRI performed within five days of antiretroviral therapy (ART) initiation. Volumes for the amygdala, caudate nucleus, hippocampus, nucleus accumbens, pallidum, putamen, and thalamus were compared across groups.
Participants in late Fiebig stages exhibited larger volumes in the nucleus accumbens (8% larger; P = 0.049) and putamen (19%; P < 0.001) when compared to participants in the early Fiebig. Compared to PWOH, participants in late Fiebig exhibited larger volumes of the amygdala (9% larger; P = 0.002), caudate nucleus (11%; P = 0.005), nucleus accumbens (15%; P = 0.004), pallidum (19%; P = 0.001), and putamen (31%; P < 0.001). Brain volumes in the nucleus accumbens, pallidum, and putamen correlated modestly with stimulant use over the past four months among late Fiebig individuals ( P s < 0.05).
Findings indicate that brain volume alterations occur in acute infection, with the most prominent differences evident in the later stages of AHI. Additional studies are needed to evaluate mechanisms for possible brain disruption following ART, including viral factors and markers of neuroinflammation.</description><subject>Adolescent</subject><subject>Adult</subject><subject>Brain - diagnostic imaging</subject><subject>Cross-Sectional Studies</subject><subject>HIV</subject><subject>HIV Infections - complications</subject><subject>HIV Infections - drug therapy</subject><subject>Humans</subject><subject>Magnetic Resonance Imaging - methods</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Young Adult</subject><issn>0269-9370</issn><issn>1473-5571</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2023</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpdkV1PwyAUhonR6Pz4B8b00psqFFrKlfHbJUuMiXpLTunphnatQuuyfy9zU6fcEDjPeTh5IeSQ0RNGlTx9OL86oWuLC5VtkAETksdpKtkmGdAkU7Hiku6QXe9fApTSPN8mOzyTSeDZgJxdOLBN9NHW_RQ7Z42PSltV6KJiHt1YLOw48h2MMQoUmL7D6G74HA4Vms62zT7ZqqD2eLDa98jTzfXj5V08ur8dXp6PYiNozmIwilcCZIqpMWXFU2CmxAyMKJTAygjOUAFNlSzyvMw4Z0VSgMihTGiZAfA9crb0vvXFFEuDTeeg1m_OTsHNdQtW_600dqLH7YdmlEqV5jwYjlcG17736Ds9td5gXUODbe91IiXLeC6FCKhYosa13jusft5hVC_C1yF8_T_80Ha0PuNP03fav95ZW3fo_Gvdz9DpCULdTb58CeU0TmjCw08xGi-uGP8EQxCP5g</recordid><startdate>20230501</startdate><enddate>20230501</enddate><creator>Bolzenius, Jacob</creator><creator>Sacdalan, Carlo</creator><creator>Ndhlovu, Lishomwa C.</creator><creator>Sailasuta, Napapon</creator><creator>Trautmann, Lydie</creator><creator>Tipsuk, Somporn</creator><creator>Crowell, Trevor A.</creator><creator>Suttichom, Duanghathai</creator><creator>Colby, Donn J.</creator><creator>Phanuphak, Nittaya</creator><creator>Chan, Phillip</creator><creator>Premeaux, Thomas</creator><creator>Kroon, Eugène</creator><creator>Vasan, Sandhya</creator><creator>Hsu, Denise C.</creator><creator>Valcour, Victor</creator><creator>Ananworanich, Jintanat</creator><creator>Robb, Merlin L.</creator><creator>Ake, Julie A.</creator><creator>Pohl, Kilian M.</creator><creator>Sriplienchan, Somchai</creator><creator>Spudich, Serena</creator><creator>Paul, Robert</creator><general>Lippincott Williams & Wilkins</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20230501</creationdate><title>Brain volumetrics differ by Fiebig stage in acute HIV infection</title><author>Bolzenius, Jacob ; Sacdalan, Carlo ; Ndhlovu, Lishomwa C. ; Sailasuta, Napapon ; Trautmann, Lydie ; Tipsuk, Somporn ; Crowell, Trevor A. ; Suttichom, Duanghathai ; Colby, Donn J. ; Phanuphak, Nittaya ; Chan, Phillip ; Premeaux, Thomas ; Kroon, Eugène ; Vasan, Sandhya ; Hsu, Denise C. ; Valcour, Victor ; Ananworanich, Jintanat ; Robb, Merlin L. ; Ake, Julie A. ; Pohl, Kilian M. ; Sriplienchan, Somchai ; Spudich, Serena ; Paul, Robert</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4081-ac93f4a75e5ccdf35a1cde6ac4b94efc431e9a0597b88d6331b2ba48ad20d6aa3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2023</creationdate><topic>Adolescent</topic><topic>Adult</topic><topic>Brain - diagnostic imaging</topic><topic>Cross-Sectional Studies</topic><topic>HIV</topic><topic>HIV Infections - complications</topic><topic>HIV Infections - drug therapy</topic><topic>Humans</topic><topic>Magnetic Resonance Imaging - methods</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Young Adult</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Bolzenius, Jacob</creatorcontrib><creatorcontrib>Sacdalan, Carlo</creatorcontrib><creatorcontrib>Ndhlovu, Lishomwa C.</creatorcontrib><creatorcontrib>Sailasuta, Napapon</creatorcontrib><creatorcontrib>Trautmann, Lydie</creatorcontrib><creatorcontrib>Tipsuk, Somporn</creatorcontrib><creatorcontrib>Crowell, Trevor A.</creatorcontrib><creatorcontrib>Suttichom, Duanghathai</creatorcontrib><creatorcontrib>Colby, Donn J.</creatorcontrib><creatorcontrib>Phanuphak, Nittaya</creatorcontrib><creatorcontrib>Chan, Phillip</creatorcontrib><creatorcontrib>Premeaux, Thomas</creatorcontrib><creatorcontrib>Kroon, Eugène</creatorcontrib><creatorcontrib>Vasan, Sandhya</creatorcontrib><creatorcontrib>Hsu, Denise C.</creatorcontrib><creatorcontrib>Valcour, Victor</creatorcontrib><creatorcontrib>Ananworanich, Jintanat</creatorcontrib><creatorcontrib>Robb, Merlin L.</creatorcontrib><creatorcontrib>Ake, Julie A.</creatorcontrib><creatorcontrib>Pohl, Kilian M.</creatorcontrib><creatorcontrib>Sriplienchan, Somchai</creatorcontrib><creatorcontrib>Spudich, Serena</creatorcontrib><creatorcontrib>Paul, Robert</creatorcontrib><creatorcontrib>RV254/SEARCH010, RV304/SEARCH013 Study Teams</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>AIDS (London)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Bolzenius, Jacob</au><au>Sacdalan, Carlo</au><au>Ndhlovu, Lishomwa C.</au><au>Sailasuta, Napapon</au><au>Trautmann, Lydie</au><au>Tipsuk, Somporn</au><au>Crowell, Trevor A.</au><au>Suttichom, Duanghathai</au><au>Colby, Donn J.</au><au>Phanuphak, Nittaya</au><au>Chan, Phillip</au><au>Premeaux, Thomas</au><au>Kroon, Eugène</au><au>Vasan, Sandhya</au><au>Hsu, Denise C.</au><au>Valcour, Victor</au><au>Ananworanich, Jintanat</au><au>Robb, Merlin L.</au><au>Ake, Julie A.</au><au>Pohl, Kilian M.</au><au>Sriplienchan, Somchai</au><au>Spudich, Serena</au><au>Paul, Robert</au><aucorp>RV254/SEARCH010, RV304/SEARCH013 Study Teams</aucorp><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Brain volumetrics differ by Fiebig stage in acute HIV infection</atitle><jtitle>AIDS (London)</jtitle><addtitle>AIDS</addtitle><date>2023-05-01</date><risdate>2023</risdate><volume>37</volume><issue>6</issue><spage>861</spage><epage>869</epage><pages>861-869</pages><issn>0269-9370</issn><eissn>1473-5571</eissn><abstract>People with chronic HIV exhibit lower regional brain volumes compared to people without HIV (PWOH). Whether imaging alterations observed in chronic infection occur in acute HIV infection (AHI) remains unknown.
Cross-sectional study of Thai participants with AHI.
One hundred and twelve Thai males with AHI (age 20-46) and 18 male Thai PWOH (age 18-40) were included. Individuals with AHI were stratified into early (Fiebig I-II; n = 32) and late (Fiebig III-V; n = 80) stages of acute infection using validated assays. T1-weighted scans were acquired using a 3 T MRI performed within five days of antiretroviral therapy (ART) initiation. Volumes for the amygdala, caudate nucleus, hippocampus, nucleus accumbens, pallidum, putamen, and thalamus were compared across groups.
Participants in late Fiebig stages exhibited larger volumes in the nucleus accumbens (8% larger; P = 0.049) and putamen (19%; P < 0.001) when compared to participants in the early Fiebig. Compared to PWOH, participants in late Fiebig exhibited larger volumes of the amygdala (9% larger; P = 0.002), caudate nucleus (11%; P = 0.005), nucleus accumbens (15%; P = 0.004), pallidum (19%; P = 0.001), and putamen (31%; P < 0.001). Brain volumes in the nucleus accumbens, pallidum, and putamen correlated modestly with stimulant use over the past four months among late Fiebig individuals ( P s < 0.05).
Findings indicate that brain volume alterations occur in acute infection, with the most prominent differences evident in the later stages of AHI. Additional studies are needed to evaluate mechanisms for possible brain disruption following ART, including viral factors and markers of neuroinflammation.</abstract><cop>England</cop><pub>Lippincott Williams & Wilkins</pub><pmid>36723491</pmid><doi>10.1097/QAD.0000000000003496</doi><tpages>9</tpages></addata></record> |
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| source | MEDLINE; EZB-FREE-00999 freely available EZB journals |
| subjects | Adolescent Adult Brain - diagnostic imaging Cross-Sectional Studies HIV HIV Infections - complications HIV Infections - drug therapy Humans Magnetic Resonance Imaging - methods Male Middle Aged Young Adult |
| title | Brain volumetrics differ by Fiebig stage in acute HIV infection |
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