Associations between clinical and histopathological characteristics in oral leukoplakia
Objectives To identify possible associations between patients’ demographics and habits and the clinical aspects and histopathological characteristics of oral leukoplakia (OL) at patients’ first visit. Method A total of 140 consecutive patients with OL at a single institute between 1997 and 2019. All...
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| Veröffentlicht in: | Oral diseases 2023-03, Vol.29 (2), p.696-706 |
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| creator | Evren, Ilkay Brouns, Elisabeth R. Poell, Jos B. Wils, Leon J. Brakenhoff, Ruud H. Bloemena, Elisabeth Visscher, Jan G.A.M. |
| description | Objectives
To identify possible associations between patients’ demographics and habits and the clinical aspects and histopathological characteristics of oral leukoplakia (OL) at patients’ first visit.
Method
A total of 140 consecutive patients with OL at a single institute between 1997 and 2019. All biopsies were microscopically examined for classic dysplasia (CD) (WHO definition oral epithelial dysplasia) and differentiated dysplasia (DD) known from differentiated vulvar intraepithelial neoplasia. Clinical characteristics were correlated to histopathological diagnosis and odds ratios (OR) were calculated.
Results
A total of 96 females and 44 males, mean age 58 years, were presented. OLs were found mainly on the tongue (41%) and floor of mouth (FOM) (18%). Homogeneous OLs (58%) were associated with smoking, FOM and size |
| doi_str_mv | 10.1111/odi.14038 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_10078678</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2772168202</sourcerecordid><originalsourceid>FETCH-LOGICAL-c4448-6af1c4583e97adef1b5a4a33a7a7720fe05ff94dd0b1de22fee64e1634cbec4b3</originalsourceid><addsrcrecordid>eNp1kU1LHTEUhkNpUasu-gfKQDd2MffmayYzqyLWLxDcKLoLZzJnvNHc5DaZqfjvjV4VWzCbhHMeHt7wEvKN0RnLZx56O2OSiuYT2WI1ZSVtePU5v0Uly4qL603yNaVbSplqBd8gm0JmSim6Ra72UwrGwmiDT0WH4z2iL4yz3hpwBfi-WNg0hhWMi-DCzfPULCCCGTHmjTWpsL4IMc8dTndh5eDOwg75MoBLuPtyb5PLo8OLg5Py7Pz49GD_rDRSyqasYWBGVo3AVkGPA-sqkCAEKFCK0wFpNQyt7HvasR45HxBriawW0nRoZCe2ya-1dzV1S-wN-jEn0atolxAfdACr_914u9A34a9mlKqmVk027L0YYvgzYRr10iaDzoHHMCXNK9XSVghaZ_THf-htmKLP_9M8x2V1wynP1M81ZWJIKeLwloZR_dSXzn3p574y-_19_DfytaAMzNfAvXX48LFJn_8-XSsfAVEloho</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2772168202</pqid></control><display><type>article</type><title>Associations between clinical and histopathological characteristics in oral leukoplakia</title><source>MEDLINE</source><source>Wiley Online Library Journals Frontfile Complete</source><creator>Evren, Ilkay ; Brouns, Elisabeth R. ; Poell, Jos B. ; Wils, Leon J. ; Brakenhoff, Ruud H. ; Bloemena, Elisabeth ; Visscher, Jan G.A.M.</creator><creatorcontrib>Evren, Ilkay ; Brouns, Elisabeth R. ; Poell, Jos B. ; Wils, Leon J. ; Brakenhoff, Ruud H. ; Bloemena, Elisabeth ; Visscher, Jan G.A.M.</creatorcontrib><description>Objectives
To identify possible associations between patients’ demographics and habits and the clinical aspects and histopathological characteristics of oral leukoplakia (OL) at patients’ first visit.
Method
A total of 140 consecutive patients with OL at a single institute between 1997 and 2019. All biopsies were microscopically examined for classic dysplasia (CD) (WHO definition oral epithelial dysplasia) and differentiated dysplasia (DD) known from differentiated vulvar intraepithelial neoplasia. Clinical characteristics were correlated to histopathological diagnosis and odds ratios (OR) were calculated.
Results
A total of 96 females and 44 males, mean age 58 years, were presented. OLs were found mainly on the tongue (41%) and floor of mouth (FOM) (18%). Homogeneous OLs (58%) were associated with smoking, FOM and size <2cm and non‐homogeneous OLs (42%) with non‐smokers. No dysplasia was present in 40% and any dysplasia (AD) in 60%. Tongue OLs were correlated with AD (OR:6.0) and CD (OR:5.7). FOM OLs were correlated with CD (OR:4.5). DD was correlated with non‐homogeneous OLs (OR:2.6).
Conclusions
CD was most frequently observed in tongue and FOM OLs, while DD was associated with non‐homogeneous OLs. In this series of patients, there was no consistent reliable association between the clinical and histopathological features and clinical characteristics can therefore not substitute microscopic examination of biopsies.</description><identifier>ISSN: 1354-523X</identifier><identifier>EISSN: 1601-0825</identifier><identifier>DOI: 10.1111/odi.14038</identifier><identifier>PMID: 34601770</identifier><language>eng</language><publisher>Denmark: Wiley Subscription Services, Inc</publisher><subject>Biopsy ; Cancer and Potentially Malignant Disorders ; Carcinoma, Squamous Cell - pathology ; Cell Transformation, Neoplastic - pathology ; Clinical aspects ; differentiated dysplasia ; Dysplasia ; Female ; homogeneous leukoplakia ; Humans ; Hyperplasia - pathology ; Leukokeratosis ; leukoplakia ; Leukoplakia, Oral - pathology ; Male ; Middle Aged ; non‐homogeneous leukoplakia ; Oral cancer ; oral cavity ; oral epithelial dysplasia ; oral leukoplakia ; oral potentially malignant disorder ; Original ; Smoking ; Tongue</subject><ispartof>Oral diseases, 2023-03, Vol.29 (2), p.696-706</ispartof><rights>2021 The Authors. published by Wiley Periodicals LLC.</rights><rights>2021 The Authors. Oral Diseases published by Wiley Periodicals LLC.</rights><rights>2021. This article is published under http://creativecommons.org/licenses/by-nc-nd/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4448-6af1c4583e97adef1b5a4a33a7a7720fe05ff94dd0b1de22fee64e1634cbec4b3</citedby><cites>FETCH-LOGICAL-c4448-6af1c4583e97adef1b5a4a33a7a7720fe05ff94dd0b1de22fee64e1634cbec4b3</cites><orcidid>0000-0003-1776-3779 ; 0000-0001-5404-1041 ; 0000-0002-2238-3300 ; 0000-0002-0221-9538 ; 0000-0003-3665-3751 ; 0000-0003-3251-5378 ; 0000-0001-9669-7452</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fodi.14038$$EPDF$$P50$$Gwiley$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fodi.14038$$EHTML$$P50$$Gwiley$$Hfree_for_read</linktohtml><link.rule.ids>230,314,776,780,881,1411,27901,27902,45550,45551</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/34601770$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Evren, Ilkay</creatorcontrib><creatorcontrib>Brouns, Elisabeth R.</creatorcontrib><creatorcontrib>Poell, Jos B.</creatorcontrib><creatorcontrib>Wils, Leon J.</creatorcontrib><creatorcontrib>Brakenhoff, Ruud H.</creatorcontrib><creatorcontrib>Bloemena, Elisabeth</creatorcontrib><creatorcontrib>Visscher, Jan G.A.M.</creatorcontrib><title>Associations between clinical and histopathological characteristics in oral leukoplakia</title><title>Oral diseases</title><addtitle>Oral Dis</addtitle><description>Objectives
To identify possible associations between patients’ demographics and habits and the clinical aspects and histopathological characteristics of oral leukoplakia (OL) at patients’ first visit.
Method
A total of 140 consecutive patients with OL at a single institute between 1997 and 2019. All biopsies were microscopically examined for classic dysplasia (CD) (WHO definition oral epithelial dysplasia) and differentiated dysplasia (DD) known from differentiated vulvar intraepithelial neoplasia. Clinical characteristics were correlated to histopathological diagnosis and odds ratios (OR) were calculated.
Results
A total of 96 females and 44 males, mean age 58 years, were presented. OLs were found mainly on the tongue (41%) and floor of mouth (FOM) (18%). Homogeneous OLs (58%) were associated with smoking, FOM and size <2cm and non‐homogeneous OLs (42%) with non‐smokers. No dysplasia was present in 40% and any dysplasia (AD) in 60%. Tongue OLs were correlated with AD (OR:6.0) and CD (OR:5.7). FOM OLs were correlated with CD (OR:4.5). DD was correlated with non‐homogeneous OLs (OR:2.6).
Conclusions
CD was most frequently observed in tongue and FOM OLs, while DD was associated with non‐homogeneous OLs. In this series of patients, there was no consistent reliable association between the clinical and histopathological features and clinical characteristics can therefore not substitute microscopic examination of biopsies.</description><subject>Biopsy</subject><subject>Cancer and Potentially Malignant Disorders</subject><subject>Carcinoma, Squamous Cell - pathology</subject><subject>Cell Transformation, Neoplastic - pathology</subject><subject>Clinical aspects</subject><subject>differentiated dysplasia</subject><subject>Dysplasia</subject><subject>Female</subject><subject>homogeneous leukoplakia</subject><subject>Humans</subject><subject>Hyperplasia - pathology</subject><subject>Leukokeratosis</subject><subject>leukoplakia</subject><subject>Leukoplakia, Oral - pathology</subject><subject>Male</subject><subject>Middle Aged</subject><subject>non‐homogeneous leukoplakia</subject><subject>Oral cancer</subject><subject>oral cavity</subject><subject>oral epithelial dysplasia</subject><subject>oral leukoplakia</subject><subject>oral potentially malignant disorder</subject><subject>Original</subject><subject>Smoking</subject><subject>Tongue</subject><issn>1354-523X</issn><issn>1601-0825</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2023</creationdate><recordtype>article</recordtype><sourceid>24P</sourceid><sourceid>EIF</sourceid><recordid>eNp1kU1LHTEUhkNpUasu-gfKQDd2MffmayYzqyLWLxDcKLoLZzJnvNHc5DaZqfjvjV4VWzCbhHMeHt7wEvKN0RnLZx56O2OSiuYT2WI1ZSVtePU5v0Uly4qL603yNaVbSplqBd8gm0JmSim6Ra72UwrGwmiDT0WH4z2iL4yz3hpwBfi-WNg0hhWMi-DCzfPULCCCGTHmjTWpsL4IMc8dTndh5eDOwg75MoBLuPtyb5PLo8OLg5Py7Pz49GD_rDRSyqasYWBGVo3AVkGPA-sqkCAEKFCK0wFpNQyt7HvasR45HxBriawW0nRoZCe2ya-1dzV1S-wN-jEn0atolxAfdACr_914u9A34a9mlKqmVk027L0YYvgzYRr10iaDzoHHMCXNK9XSVghaZ_THf-htmKLP_9M8x2V1wynP1M81ZWJIKeLwloZR_dSXzn3p574y-_19_DfytaAMzNfAvXX48LFJn_8-XSsfAVEloho</recordid><startdate>202303</startdate><enddate>202303</enddate><creator>Evren, Ilkay</creator><creator>Brouns, Elisabeth R.</creator><creator>Poell, Jos B.</creator><creator>Wils, Leon J.</creator><creator>Brakenhoff, Ruud H.</creator><creator>Bloemena, Elisabeth</creator><creator>Visscher, Jan G.A.M.</creator><general>Wiley Subscription Services, Inc</general><general>John Wiley and Sons Inc</general><scope>24P</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QP</scope><scope>K9.</scope><scope>7X8</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0003-1776-3779</orcidid><orcidid>https://orcid.org/0000-0001-5404-1041</orcidid><orcidid>https://orcid.org/0000-0002-2238-3300</orcidid><orcidid>https://orcid.org/0000-0002-0221-9538</orcidid><orcidid>https://orcid.org/0000-0003-3665-3751</orcidid><orcidid>https://orcid.org/0000-0003-3251-5378</orcidid><orcidid>https://orcid.org/0000-0001-9669-7452</orcidid></search><sort><creationdate>202303</creationdate><title>Associations between clinical and histopathological characteristics in oral leukoplakia</title><author>Evren, Ilkay ; Brouns, Elisabeth R. ; Poell, Jos B. ; Wils, Leon J. ; Brakenhoff, Ruud H. ; Bloemena, Elisabeth ; Visscher, Jan G.A.M.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4448-6af1c4583e97adef1b5a4a33a7a7720fe05ff94dd0b1de22fee64e1634cbec4b3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2023</creationdate><topic>Biopsy</topic><topic>Cancer and Potentially Malignant Disorders</topic><topic>Carcinoma, Squamous Cell - pathology</topic><topic>Cell Transformation, Neoplastic - pathology</topic><topic>Clinical aspects</topic><topic>differentiated dysplasia</topic><topic>Dysplasia</topic><topic>Female</topic><topic>homogeneous leukoplakia</topic><topic>Humans</topic><topic>Hyperplasia - pathology</topic><topic>Leukokeratosis</topic><topic>leukoplakia</topic><topic>Leukoplakia, Oral - pathology</topic><topic>Male</topic><topic>Middle Aged</topic><topic>non‐homogeneous leukoplakia</topic><topic>Oral cancer</topic><topic>oral cavity</topic><topic>oral epithelial dysplasia</topic><topic>oral leukoplakia</topic><topic>oral potentially malignant disorder</topic><topic>Original</topic><topic>Smoking</topic><topic>Tongue</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Evren, Ilkay</creatorcontrib><creatorcontrib>Brouns, Elisabeth R.</creatorcontrib><creatorcontrib>Poell, Jos B.</creatorcontrib><creatorcontrib>Wils, Leon J.</creatorcontrib><creatorcontrib>Brakenhoff, Ruud H.</creatorcontrib><creatorcontrib>Bloemena, Elisabeth</creatorcontrib><creatorcontrib>Visscher, Jan G.A.M.</creatorcontrib><collection>Wiley Online Library Open Access</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Oral diseases</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Evren, Ilkay</au><au>Brouns, Elisabeth R.</au><au>Poell, Jos B.</au><au>Wils, Leon J.</au><au>Brakenhoff, Ruud H.</au><au>Bloemena, Elisabeth</au><au>Visscher, Jan G.A.M.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Associations between clinical and histopathological characteristics in oral leukoplakia</atitle><jtitle>Oral diseases</jtitle><addtitle>Oral Dis</addtitle><date>2023-03</date><risdate>2023</risdate><volume>29</volume><issue>2</issue><spage>696</spage><epage>706</epage><pages>696-706</pages><issn>1354-523X</issn><eissn>1601-0825</eissn><abstract>Objectives
To identify possible associations between patients’ demographics and habits and the clinical aspects and histopathological characteristics of oral leukoplakia (OL) at patients’ first visit.
Method
A total of 140 consecutive patients with OL at a single institute between 1997 and 2019. All biopsies were microscopically examined for classic dysplasia (CD) (WHO definition oral epithelial dysplasia) and differentiated dysplasia (DD) known from differentiated vulvar intraepithelial neoplasia. Clinical characteristics were correlated to histopathological diagnosis and odds ratios (OR) were calculated.
Results
A total of 96 females and 44 males, mean age 58 years, were presented. OLs were found mainly on the tongue (41%) and floor of mouth (FOM) (18%). Homogeneous OLs (58%) were associated with smoking, FOM and size <2cm and non‐homogeneous OLs (42%) with non‐smokers. No dysplasia was present in 40% and any dysplasia (AD) in 60%. Tongue OLs were correlated with AD (OR:6.0) and CD (OR:5.7). FOM OLs were correlated with CD (OR:4.5). DD was correlated with non‐homogeneous OLs (OR:2.6).
Conclusions
CD was most frequently observed in tongue and FOM OLs, while DD was associated with non‐homogeneous OLs. In this series of patients, there was no consistent reliable association between the clinical and histopathological features and clinical characteristics can therefore not substitute microscopic examination of biopsies.</abstract><cop>Denmark</cop><pub>Wiley Subscription Services, Inc</pub><pmid>34601770</pmid><doi>10.1111/odi.14038</doi><tpages>11</tpages><orcidid>https://orcid.org/0000-0003-1776-3779</orcidid><orcidid>https://orcid.org/0000-0001-5404-1041</orcidid><orcidid>https://orcid.org/0000-0002-2238-3300</orcidid><orcidid>https://orcid.org/0000-0002-0221-9538</orcidid><orcidid>https://orcid.org/0000-0003-3665-3751</orcidid><orcidid>https://orcid.org/0000-0003-3251-5378</orcidid><orcidid>https://orcid.org/0000-0001-9669-7452</orcidid><oa>free_for_read</oa></addata></record> |
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| ispartof | Oral diseases, 2023-03, Vol.29 (2), p.696-706 |
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| source | MEDLINE; Wiley Online Library Journals Frontfile Complete |
| subjects | Biopsy Cancer and Potentially Malignant Disorders Carcinoma, Squamous Cell - pathology Cell Transformation, Neoplastic - pathology Clinical aspects differentiated dysplasia Dysplasia Female homogeneous leukoplakia Humans Hyperplasia - pathology Leukokeratosis leukoplakia Leukoplakia, Oral - pathology Male Middle Aged non‐homogeneous leukoplakia Oral cancer oral cavity oral epithelial dysplasia oral leukoplakia oral potentially malignant disorder Original Smoking Tongue |
| title | Associations between clinical and histopathological characteristics in oral leukoplakia |
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