Human Amylin in the Presence of SARS-COV‑2 Protein Fragments

Human Amylin in the Presence of SARS-COV‑2 Protein Fragments

COVID-19 can lead to the onset of type-II diabetes, which is associated with the aggregation of islet amyloid polypeptides, also called amylin. Using molecular dynamics simulations, we investigate how the equilibrium between amylin monomers in its functional form and fibrils associated with diabetes...

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Veröffentlicht in:ACS omega 2023-04, Vol.8 (13), p.12501-12511
Hauptverfasser: Chesney, Andrew D., Maiti, Buddhadev, Hansmann, Ulrich H.E.
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Maiti, Buddhadev
Hansmann, Ulrich H.E.
description COVID-19 can lead to the onset of type-II diabetes, which is associated with the aggregation of islet amyloid polypeptides, also called amylin. Using molecular dynamics simulations, we investigate how the equilibrium between amylin monomers in its functional form and fibrils associated with diabetes is altered in the presence of SARS-COV-2 protein fragments. For this purpose, we study the interaction between the fragment SFYVYSRVK of the envelope protein or the fragment FKNIDGYFKI of the spike protein with the monomer and two amylin fibril models. Our results are compared with earlier work studying such interactions for the two different proteins.
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title Human Amylin in the Presence of SARS-COV‑2 Protein Fragments
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