Apolipoprotein M Attenuates Anthracycline Cardiotoxicity and Lysosomal Injury

[Display omitted] •Circulating ApoM is inversely associated with mortality in human anthracycline-induced cardiomyopathy.•Anthracycline treatment reduces circulating ApoM in humans and mice.•Increasing ApoM attenuates doxorubicin cardiotoxicity and lysosomal injury and preserves myocardial autophagi...

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Veröffentlicht in:	JACC. Basic to translational science 2023-03, Vol.8 (3), p.340-355
Hauptverfasser:	Guo, Zhen, Valenzuela Ripoll, Carla, Picataggi, Antonino, Rawnsley, David R., Ozcan, Mualla, Chirinos, Julio A., Chendamarai, Ezhilarasi, Girardi, Amanda, Riehl, Terrence, Evie, Hosannah, Diab, Ahmed, Kovacs, Attila, Hyrc, Krzysztof, Ma, Xiucui, Asnani, Aarti, Shewale, Swapnil V., Scherrer-Crosbie, Marielle, Cowart, Lauren Ashley, Parks, John S., Zhao, Lei, Gordon, David, Ramirez-Valle, Francisco, Margulies, Kenneth B., Cappola, Thomas P., Desai, Ankit A., Pedersen, Lauren N., Bergom, Carmen, Stitziel, Nathan O., Rettig, Michael P., DiPersio, John F., Hajny, Stefan, Christoffersen, Christina, Diwan, Abhinav, Javaheri, Ali
Format:	Artikel
Sprache:	eng
Schlagworte:	anthracycline apolipoprotein M autophagy cardiomyopathy Original Research - Preclinical TFEB
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