Oxime@Zirconium-Metal–Organic Framework Hybrid Material as a Potential Antidote for Organophosphate Poisoning

A novel material with dual activity toward organophosphate (OP) poisoning, based on Zr-MOF-808 and neutral oxime RS69N, has been prepared. The hybrid material has a significant drug payload (5.2 ± 0.9 oxime to MOF-808 molar ratio) and shows a sustained oxime release in simulated physiological media,...

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Veröffentlicht in:	Inorganic chemistry 2023-04, Vol.62 (13), p.5049-5053
Hauptverfasser:	González, Lydia, Martín-Romera, Javier D., Sánchez-Sánchez, Purificación, Navarro, Jorge A. R., Barea, Elisa, Maldonado, Carmen R., Carmona, Francisco J.
Format:	Artikel
Sprache:	eng
Schlagworte:	Acetylcholinesterase Antidotes Cholinesterase Inhibitors - pharmacology Cholinesterase Reactivators - pharmacology Communication Humans Metal-Organic Frameworks Organophosphate Poisoning Organophosphorus Compounds - pharmacology Oximes - pharmacology Zirconium
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container_issue	13
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container_title	Inorganic chemistry
container_volume	62
creator	González, Lydia Martín-Romera, Javier D. Sánchez-Sánchez, Purificación Navarro, Jorge A. R. Barea, Elisa Maldonado, Carmen R. Carmona, Francisco J.
description	A novel material with dual activity toward organophosphate (OP) poisoning, based on Zr-MOF-808 and neutral oxime RS69N, has been prepared. The hybrid material has a significant drug payload (5.2 ± 0.9 oxime to MOF-808 molar ratio) and shows a sustained oxime release in simulated physiological media, leading to the successful reactivation of OP-inhibited acetylcholinesterase. At the same time, the hybrid system presents an efficient and moderately fast removal rate of a toxic organophosphorus model compound (diisopropylfluorophosphate) from simulated physiological media (t 1/2 = 183 min; 95% removal rate after 24 h).
doi_str_mv	10.1021/acs.inorgchem.3c00121
format	Article
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At the same time, the hybrid system presents an efficient and moderately fast removal rate of a toxic organophosphorus model compound (diisopropylfluorophosphate) from simulated physiological media (t 1/2 = 183 min; 95% removal rate after 24 h).</description><subject>Acetylcholinesterase</subject><subject>Antidotes</subject><subject>Cholinesterase Inhibitors - pharmacology</subject><subject>Cholinesterase Reactivators - pharmacology</subject><subject>Communication</subject><subject>Humans</subject><subject>Metal-Organic Frameworks</subject><subject>Organophosphate Poisoning</subject><subject>Organophosphorus Compounds - pharmacology</subject><subject>Oximes - pharmacology</subject><subject>Zirconium</subject><issn>0020-1669</issn><issn>1520-510X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2023</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkc9u1DAQxq0K1C4LjwDKkUuWcewk9qlUVf9JrbYHkBAXa9axd90m8WIn0N54B96QJ6mXXVblxGk8mt_3eTQfIW8pzCgU9APqOHO9D0u9Mt2MaQBa0AMyoWUBeUnhywsyAUhvWlXyiLyK8Q4AJOPVITlilWRScDYhfv7gOvPxqwva927s8hszYPv75695WGLvdHYesDM_fLjPLh8XwTXZDQ4mOGwzjBlmt34w_bBpT1JpUpdZH7I_ar9e-bheJT5hLib_fvmavLTYRvNmV6fk8_nZp9PL_Hp-cXV6cp0jL_mQC9YYgFLoomoKwWVV1sKWDVorRI00zRo0uq44lZJLvbBGsopbK2UJnELDpuR467seF51pdFoyYKvWwXUYHpVHp_6d9G6llv67ogA1Z-k2U_J-5xD8t9HEQXUuatO22Bs_RlXUQggAJouElltUBx9jMHb_DwW1SUultNQ-LbVLK-nePV9yr_obTwLoFtjo7_wY-nSz_5g-ATYVqUQ</recordid><startdate>20230403</startdate><enddate>20230403</enddate><creator>González, Lydia</creator><creator>Martín-Romera, Javier D.</creator><creator>Sánchez-Sánchez, Purificación</creator><creator>Navarro, Jorge A. R.</creator><creator>Barea, Elisa</creator><creator>Maldonado, Carmen R.</creator><creator>Carmona, Francisco J.</creator><general>American Chemical Society</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0002-0535-9421</orcidid><orcidid>https://orcid.org/0000-0001-9895-1047</orcidid><orcidid>https://orcid.org/0000-0002-4958-6052</orcidid><orcidid>https://orcid.org/0000-0002-8359-0397</orcidid><orcidid>https://orcid.org/0000-0001-8489-6446</orcidid><orcidid>https://orcid.org/0000-0002-1676-1870</orcidid></search><sort><creationdate>20230403</creationdate><title>Oxime@Zirconium-Metal–Organic Framework Hybrid Material as a Potential Antidote for Organophosphate Poisoning</title><author>González, Lydia ; Martín-Romera, Javier D. ; Sánchez-Sánchez, Purificación ; Navarro, Jorge A. 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subjects	Acetylcholinesterase Antidotes Cholinesterase Inhibitors - pharmacology Cholinesterase Reactivators - pharmacology Communication Humans Metal-Organic Frameworks Organophosphate Poisoning Organophosphorus Compounds - pharmacology Oximes - pharmacology Zirconium
title	Oxime@Zirconium-Metal–Organic Framework Hybrid Material as a Potential Antidote for Organophosphate Poisoning
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