Saturated fatty acids increase LPI to reduce FUNDC1 dimerization and stability and mitochondrial function

Ectopic lipid deposition and mitochondrial dysfunction are common etiologies of obesity and metabolic disorders. Excessive dietary uptake of saturated fatty acids (SFAs) causes mitochondrial dysfunction and metabolic disorders, while unsaturated fatty acids (UFAs) counterbalance these detrimental ef...

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Veröffentlicht in:	EMBO reports 2023-04, Vol.24 (4), p.e54731-n/a
Hauptverfasser:	Chen, Linbo, Zhang, Qianping, Meng, Yuanyuan, Zhao, Tian, Mu, Chenglong, Fu, Changying, Deng, Caijuan, Feng, Jianyu, Du, Siling, Liu, Wei, Geng, Guangfeng, Ma, Kaili, Cheng, Hongcheng, Liu, Qiangqiang, Luo, Qian, Zhang, Jiaojiao, Du, Zhanqiang, Cao, Lin, Wang, Hui, Liu, Yong, Lin, Jianping, Chen, Guo, Liu, Lei, Lam, Sin Man, Shui, Guanghou, Zhu, Yushan, Chen, Quan
Format:	Artikel
Sprache:	eng
Schlagworte:	Acetylation Animals Cholesterol Degradation Dimerization Dimers EMBO21 fatty acid metabolism Fatty acids Fatty Acids - metabolism FUNDC1 Life Sciences Lipid metabolism Lipids membrane protein dimerization Membrane Proteins - metabolism Metabolic disorders Mice Mitochondria Mitochondria - metabolism Mitochondrial Proteins - metabolism mitochondrial quality control Mitophagy Monomers Oleic acid Palmitic acid Proteasomes Signal transduction Stability
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