The mechanosensitive TRPV2 calcium channel promotes human melanoma invasiveness and metastatic potential

Melanoma is a highly aggressive cancer endowed with a unique capacity of rapidly metastasizing, which is fundamentally driven by aberrant cell motility behaviors. Discovering “migrastatics” targets, specifically controlling invasion and dissemination of melanoma cells during metastasis, is therefore...

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Veröffentlicht in:	EMBO reports 2023-04, Vol.24 (4), p.e55069-n/a
Hauptverfasser:	Shoji, Kenji F, Bayet, Elsa, Leverrier‐Penna, Sabrina, Le Devedec, Dahiana, Mallavialle, Aude, Marionneau‐Lambot, Séverine, Rambow, Florian, Perret, Raul, Joussaume, Aurélie, Viel, Roselyne, Fautrel, Alain, Khammari, Amir, Constantin, Bruno, Tartare‐Deckert, Sophie, Penna, Aubin
Format:	Artikel
Sprache:	eng
Schlagworte:	Actin Adhesion Aggressive behavior Biomarkers Calcium Calcium - metabolism Calcium channels Calcium Channels - genetics Calcium Channels - metabolism Calcium ions Calpain Cell Membrane - metabolism Cell Movement - genetics EMBO03 EMBO05 EMBO20 Humans Invasiveness Life Sciences Malignancy Medical prognosis Melanoma Melanoma - genetics Metastases Metastasis migration Motility Neoplasm Invasiveness - pathology Skin cancer Skin Neoplasms - genetics Talin TRPV Cation Channels - genetics TRPV2 channel Tumor cells Tumors
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